Results 71 to 80 of about 162,122 (308)

Is deliberate hypotension a safe technique for orthopedic surgery?: a systematic review and meta-analysis of parallel randomized controlled trials

Journal of Orthopaedic Surgery and Research, 2019
Background Deliberate hypotension has been shown to reduce the intraoperative bleeding and the need for allogeneic blood transfusion, and improve the surgical field, but there is still controversy on its clinical safety.
Jia Jiang, Ran Zhou, Bo Li, Fushan Xue
doaj   +1 more source

Comprehensive systematic review summary: Treatment of tics in people with Tourette syndrome and chronic tic disorders [PDF]

, 2019
Objective To systematically evaluate the efficacy of treatments for tics and the risks associated with their use. Methods This project followed the methodologies outlined in the 2011 edition of the American Academy of Neurology\u27s guideline development
Cavanna, Andrea E, Holler-Managan, Yolanda, Jankovic, Joseph, Jarvie, Elizabeth, Martino, Davide, Müller-Vahl, Kirsten, Okun, Michael S, Oskoui, Maryam, Piacentini, John, Pringsheim, Tamara, Robinson, Michael, Roessner, Veit, Woods, Douglas W   +12 more
core   +2 more sources

A critical reappraisal of the carotid sinus and carotid bulb: Distinguishing neurohistological function from vascular geometry

The Anatomical Record, EarlyView.
This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose, Nicolae Radu, Mugurel Constantin Rusu   +2 more
wiley   +1 more source

Comparison of Esmolol to Nitroglycerine in Controlling Hypotension during Nasal Surgery

Eurasian Journal of Medicine, 2019
Objective: The aim of this study was to compare esmolol to nitroglycerine in terms of effectiveness in controlling hypotension during nasal surgery.
Ayla Guney, Fatma Nur Kaya, Belgin Yavascaoglu, Alp Gurbet, Nazan Has Selmi, Sener Kaya, Oya Kutlay   +6 more
doaj   +1 more source

Dexmedetomidine in a patient with unrepaired congenital cyanotic heart disease

The Indian Anaesthetists' Forum, 2020
The challenges in a patient with unrepaired congenital cyanotic heart disease (CCHD) requiring controlled hypotension are to prevent a further increase in the right-to-left (R-L) shunt by maintaining systemic vascular resistance, controlling pulmonary ...
Kumar Parag, Nishith Govil, Vinay Rai, Abullais Raheeq Gowda   +3 more
doaj   +1 more source

Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice [PDF]

, 2015
Oxidative stress, a central mediator of cardiovascular disease, results in loss of the prosthetic haem group of soluble guanylate cyclase (sGC), preventing its activation by nitric oxide (NO). Here we introduce Apo-sGC mice expressing haem-free sGC.
Bloch, Kenneth D, Brouckaert, Peter, Buys, Emmanuel S, Cauwels, Anje, De Cauwer, Lode, Decaluwé, Kelly, Delanghe, Joris, Geschka, Sandra, Hochepied, Tino, Karas, Richard H, Rogge, Elke, Sips, Patrick, Stasch, Johannes-Peter, Tainsh, Robert E, Thoonen, Robrecht, Van de Voorde, Johan, Voet, Sofie, Vuylsteke, Marnik   +17 more
core   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Mesenteric Vascular Dysregulation and Intestinal Inflammation Accompanies Experimental Spinal Cord Injury

, 2016
Cervical and high thoracic spinal cord injury (SCI) drastically impairs autonomic nervous system function. Individuals with SCI at thoracic spinal-level 5 (T5) or higher often present cardiovascular disorders that include resting systemic arterial ...
Besecker, Emily Swartz, Cooper, Timothy K., Deiter, Gina M., Holmes, Gregory Michael, Pironi, Nicole   +4 more
core   +1 more source

Early contingentnegative variation of the EEG and attentional flexibility are reduced in hypotension [PDF]

, 2002
This study explored the question as to whether hypotension is related to decreased attentional performance and reduced cortical activation. A total of 50 females aged 19 44 years participated in the study. Attentional performance was assessed using three
Duschek, Stefan, Jacobs, Arthur M., Mialet, Jean-Paul, Schandry, Rainer, Weisz, Nathan   +4 more
core   +1 more source

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source