Results 221 to 230 of about 151,312 (311)

Clinical and genetic basis of congenital gonadotropin deficiency. [PDF]

Hum Reprod Open
Wang Y, Zhai J, Habibi I, Kolesińska Z, de Azevedo Correa F, Zouaghi Y, Ameti A, Boizot A, Perdices-López C, Todisco T, Niederländer NJ, Acierno JS, Messina A, Santoni F, Pitteloud N.   +14 more
europepmc   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Brain insulin resistance: a key pathological hub linking metabolic and neuropsychiatric comorbidities. [PDF]

Front Aging Neurosci
Tang S, Liao Y, Yang M, Yue R.
europepmc   +1 more source

Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management

Pediatric Investigation, EarlyView.
Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil, Eugene Feigin, Hussein Zaitoon   +2 more
wiley   +1 more source

Deciphering the association between morphological differences in hypothalamic subregions and circulating ghrelin and leptin concentrations: exploratory evidence in anorexia nervosa and obesity. [PDF]

Transl Psychiatry
Collantoni E, Miranda-Olivos R, Uğur S, Baenas I, Tovar S, Dieguez C, Vilarrasa N, López-Urdiales R, Guerrero-Pérez F, Jiménez-Murcia S, Soriano-Mas C, Fernández-Aranda F.   +11 more
europepmc   +1 more source

Evidence map and gap analysis of metabolic change in pediatric growth hormone deficiency treated with growth hormone

Pediatric Investigation, EarlyView.
This evidence map of 63 studies (n = 6158) showed growth hormone therapy in children with growth hormone deficiency has neutral glucose effects, mixed lipid outcomes, potential benefits for bone mineral density, bone mineral content, and parathyroid hormone, but generally no impact on thyroid function, body composition, or body mass index.
Wei Wu, Ningyi Song, Yue Zhao, Caiqi Du, Yuning Zhao, You Wu, Xiaoping Luo   +6 more
wiley   +1 more source

Pre-trauma hair cortisol moderates adverse childhood experience and hypothalamic volume effects on stress symptoms after adult trauma. [PDF]

Transl Psychiatry
Xie H, Davidson L, Hamdan RM, Shih CH, Gao W, Wall JT, McCullumsmith RE, Wang X.   +7 more
europepmc   +1 more source

Multiple eumenorrheic cycles are necessary to observe a significant increase in estrogen exposure and ovulation in exercising women with functional hypothalamic oligo/amenorrhea undergoing a nutritional intervention: Insights from the REFUEL study

PM&R, EarlyView.
Abstract Background Due to consequences of energy‐related oligo‐/amenorrhea (Oligo/Amen) among exercising females, recovery of menses (ROM) is a priority. ROM is inconsistently defined and rarely reported with reproductive hormone (estrogen, progesterone) data, making it difficult to know when females achieve adequate recovery. Objective The purpose of
Rebecca J. Mallinson, Nancy I. Williams, Emily A. Ricker, Heather C. M. Allaway, Mary Jane De Souza   +4 more
wiley   +1 more source

Safety of 12‐Months Administration of Ashwagandha (Withania somnifera) Standardized Root Extract in Healthy Adults: A Prospective, Observational Study

Phytotherapy Research, EarlyView.
ABSTRACT Ashwagandha, an adaptogen, is an important herb of Ayurveda used as a Rasayana for its various health benefits. This prospective, multi‐center, observational clinical study evaluates the safety (clinical and laboratory) of a standardized Ashwagandha Root Extract (ARE) on long‐term administration over 12 months. Male and female adults (N = 191)
Jaising Salve, Sanjeev Kale, Banwari Lal Prajapati, Adele Sparavigna, Mark Savant, John Ademola, Deepak Langade   +6 more
wiley   +1 more source

Soothing a Ruffled Mind: Chronotherapy of Cushing Syndrome. [PDF]

J Clin Endocrinol Metab
Elenius H, Nieman LK.
europepmc   +1 more source