Results 121 to 130 of about 318,025 (287)
, 2016 This paper analyzes a four-dimensional model of the hypothalamic-pituitary-adrenal (HPA) axis that includes the influence of the glucocorticoid receptor in the pituitary.
Kaslik, Eva +2 more
core +1 more source
THE AROMATIZATION OF ANDROGENS BY PRIMARY MONOLAYER CULTURES OF FETAL RAT HYPOTHALAMUS [PDF]
, 1977 Jacob A. Canick +3 more
openalex +1 more source
Sacroiliac Joint Involvement: An Underreported Complication of NF1
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT NF1‐related bone dysplasia in children and young adults with neurofibromatosis type 1 (NF1) involving the sacroiliac joint has been rarely described. We report four participants who underwent whole‐body magnetic resonance imaging (WB‐MRI) as part of a longitudinal imaging and plexiform neurofibroma (PN) biomarker study (NCT05238909) at Ann ...
Jenny P. Garzon +6 more
wiley +1 more source
Update on male reproductive endocrinology. [PDF]
, 2018 Practitioners of male reproductive and sexual medicine must have an intimate understanding of the physiology of male reproductive endocrinology, as such a knowledge is the cornerstone on which hormonal treatments are based.
Clavijo, Raul, Hsiao, Wayland
core +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Heterozygous pathogenic variants in TBX3 cause Ulnar‐Mammary syndrome (UMS). The phenotype is classically characterized by upper limb defects, apocrine/mammary gland hypoplasia, hypogonadism, and various midline defects. However, the clinical spectrum is highly variable, and some individuals may present with a mild or atypical presentation ...
Ziv Halperin, Karin Weiss
wiley +1 more source
Construction of pathogenic Sec16a mutation mouse model using CRISPR/Cas9
Animal Models and Experimental Medicine, EarlyView.Yaqiang Hu et al. engineered a pathogenic Sec16a mutant mouse model using CRISPR/Cas9 technology. They observed that the Sec16a mutant mice displayed diminished learning and memory capabilities, along with a limb‐clasping phenotype upon tail suspension.
Yaqiang Hu +6 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.Brefeldin A (BFA) significantly inhibits oocyte release and induces apoptosis in ovarian granulosa cells by disrupting follicular development. It downregulates proliferation‐associated genes, reduces SIRT1/SIRT6 proteins, and upregulates cell cycle inhibitors P21 and P16. Additionally, BFA impairs estrogen synthesis and affects ovarian function through
Yao Jiang +8 more
wiley +1 more source
Annals of Neurology, EarlyView.Objective Tofersen is the first effective and approved therapy for superoxide dismutase 1 (SOD1)‐associated amyotrophic lateral sclerosis (ALS [SOD1‐ALS]). Following treatment with tofersen, neurofilament levels in patients' cerebrospinal fluid (CSF) and serum seem to respond earlier than clinical parameters.
Christina Steffke +36 more
wiley +1 more source
Annals of Neurology, EarlyView.Objective Impaired ability to induce stepping after incomplete spinal cord injury (SCI) can limit the efficacy of locomotor training, often leaving patients wheelchair‐bound. The cuneiform nucleus (CNF), a key mesencephalic locomotor control center, modulates the activity of spinal locomotor centers via the reticulospinal tract.
Anna‐Sophie Hofer +21 more
wiley +1 more source
Annals of Neurology, EarlyView.Objective Lewy body disease (LBD) is a complex neurodegenerative disorder characterized by the accumulation of misfolded α‐synuclein in the brain. Neuroinflammation has long been implicated in LBD pathogenesis, and recent genetic studies in Parkinson's disease (a clinical manifestation of LBD) have shown consistent association with the human leukocyte ...
Marios Gavrielatos +34 more
wiley +1 more source