Mild hypothermia alleviates brain oedema and blood-brain barrier disruption by attenuating tight junction and adherens junction breakdown in a swine model of cardiopulmonary resuscitation. [PDF]
PLoS ONE, 2017 Mild hypothermia improves survival and neurological recovery after cardiac arrest (CA) and cardiopulmonary resuscitation (CPR). However, the mechanism underlying this phenomenon is not fully elucidated. The aim of this study was to determine whether mild
Jiebin Li +6 more
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Outcome and status of postcardiac arrest care in Korea: results from the Korean Hypothermia Network prospective registry [PDF]
Clinical and Experimental Emergency Medicine, 2020 Objective High-quality intensive care, including targeted temperature management (TTM) for patients with postcardiac arrest syndrome, is a key element for improving outcomes after out-of-hospital cardiac arrest (OHCA).
Soo Hyun Kim +24 more
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Targeted temperature management for ischemic stroke [PDF]
Journal of Neurocritical Care, 2019 Therapeutic hypothermia (TH) or targeted temperature management is an intentional cooling or temperature control technique using a thermostatic equipment (i.e., surface, endovascular, and focal devices) for specific therapeutic purposes.
Ji Man Hong
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Combined Cyclosporin A and Hypothermia Treatment Inhibits Activation of BV-2 Microglia but Induces an Inflammatory Response in an Ischemia/Reperfusion Hippocampal Slice Culture Model [PDF]
, 2019 Introduction: Hypothermia attenuates cerebral ischemia-induced neuronal cell death associated with neuroinflammation. The calcineurin inhibitor cyclosporin A (CsA) has been shown to be neuroprotective by minimizing activation of inflammatory pathways.
Berger, Felix +5 more
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Ventricular divergence correlates with epicardial wavebreaks and predicts ventricular arrhythmia in isolated rabbit hearts during therapeutic hypothermia [PDF]
, 2020 INTRODUCTION: High beat-to-beat morphological variation (divergence) on the ventricular electrogram during programmed ventricular stimulation (PVS) is associated with increased risk of ventricular fibrillation (VF), with unclear mechanisms.
Chen, Shih-Ann +16 more
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Post-TTM Rebound Pyrexia after Ischemia-Reperfusion Injury Results in Sterile Inflammation and Apoptosis in Cardiomyocytes [PDF]
, 2019 Introduction. Fever is frequently observed after acute ischemic events and is associated with poor outcome and higher mortality. Targeted temperature management (TTM) is recommended for neuroprotection in comatose cardiac arrest survivors, but pyrexia ...
Berger, Felix +6 more
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Therapeutic hypothermia and neurological outcome after cardiac arrest [PDF]
Vojnosanitetski Pregled, 2011 Introduction/Aim. The most important clinically relevant cause of global cerebral ischemia is cardiac arrest. Clinical studies showed a marked neuroprotective effect of mild hypothermia in resuscitation.
Petrović Milovan +6 more
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Mild hypothermia in the prevention of brain edema in acute liver failure: mechanisms and clinical prospects [PDF]
, 2002 Mild hypothermia (32 degrees C-35 degrees C) reduces intracranial pressure in patients with acute liver failure and may offer an effective adjunct therapy in the management of these patients.
Butterworth, Roger +2 more
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Acute Physiologic and Chronic Health Examination II and Sequential Organ Failure Assessment Scores for Predicting Outcomes of Out-of-Hospital Cardiac Arrest Patients Treated with Therapeutic Hypothermia [PDF]
Korean Journal of Critical Care Medicine, 2014 BACKGROUND: The aim of this study was to assess the relationship between acute physiologic and chronic health examination (APACHE) II and sequential organ failure assessment (SOFA) scores and outcomes of post-cardiac arrest patients treated with ...
Sung Joon Kim +5 more
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Modulation of 8-OH-DPAT-Induced Hypothermia by Imipramine in Rats
Journal of Pharmacological Sciences, 2003 : The effects of imipramine on 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), the 5-hydroxytryptamine (5-HT)1A-receptor full agonist, -induced hypothermia was examined in rats.
Yoshihisa Kitamura +4 more
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