Combined Cyclosporin A and Hypothermia Treatment Inhibits Activation of BV-2 Microglia but Induces an Inflammatory Response in an Ischemia/Reperfusion Hippocampal Slice Culture Model [PDF]
, 2019 Introduction: Hypothermia attenuates cerebral ischemia-induced neuronal cell death associated with neuroinflammation. The calcineurin inhibitor cyclosporin A (CsA) has been shown to be neuroprotective by minimizing activation of inflammatory pathways.
Berger, Felix +5 more
core +1 more source
International Journal of Medical Sciences, 2020 This study examined the possible upstream cellular signaling pathway associated with nitric oxide (NO)-mediated inhibition of phenylephrine-induced contraction in isolated rat aortae in response to mild hypothermia, with a particular focus on endothelial
S. Lee +7 more
semanticscholar +1 more source
Induced and Accidental Hypothermia
Critical Care and Resuscitation, 2000 To review human thermoregulation and the pathophysiology and management of induced and accidental hypothermia.A review of studies reported over ten years from 1990 to 2000 and identified through a MEDLINE search of the English-language literature on thermoregulation and induced and accidental hypothermia.Hypothermia is defined as a core temperature ...
E, Connolly, L I, Worthley
openaire +2 more sources
Mild hypothermia in the prevention of brain edema in acute liver failure: mechanisms and clinical prospects [PDF]
, 2002 Mild hypothermia (32 degrees C-35 degrees C) reduces intracranial pressure in patients with acute liver failure and may offer an effective adjunct therapy in the management of these patients.
Butterworth, Roger +2 more
core +1 more source
Ventricular divergence correlates with epicardial wavebreaks and predicts ventricular arrhythmia in isolated rabbit hearts during therapeutic hypothermia [PDF]
, 2020 INTRODUCTION: High beat-to-beat morphological variation (divergence) on the ventricular electrogram during programmed ventricular stimulation (PVS) is associated with increased risk of ventricular fibrillation (VF), with unclear mechanisms.
Chen, Shih-Ann +16 more
core +1 more source
Therapeutic hypothermia and neurological outcome after cardiac arrest [PDF]
Vojnosanitetski Pregled, 2011 Introduction/Aim. The most important clinically relevant cause of global cerebral ischemia is cardiac arrest. Clinical studies showed a marked neuroprotective effect of mild hypothermia in resuscitation.
Petrović Milovan +6 more
doaj +1 more source
Targeted temperature management for postcardiac arrest syndrome [PDF]
Journal of Neurocritical Care, 2020 Neurocritical care management to improve neurologic outcome for postcardiac arrest syndrome (PCAS) has focused considerably on targeted temperature management (TTM). TTM attenuates the destructive processes following ischemia/reperfusion in PCAS.
Yasuhiro Kuroda, Kenya Kawakita
doaj +1 more source
PLoS Genetics, 2017 Mutations in the neuron-specific α3 isoform of the Na+/K+-ATPase are found in patients suffering from Rapid onset Dystonia Parkinsonism and Alternating Hemiplegia of Childhood, two closely related movement disorders.
T. Isaksen +7 more
semanticscholar +1 more source
Acute Physiologic and Chronic Health Examination II and Sequential Organ Failure Assessment Scores for Predicting Outcomes of Out-of-Hospital Cardiac Arrest Patients Treated with Therapeutic Hypothermia [PDF]
Korean Journal of Critical Care Medicine, 2014 BACKGROUND: The aim of this study was to assess the relationship between acute physiologic and chronic health examination (APACHE) II and sequential organ failure assessment (SOFA) scores and outcomes of post-cardiac arrest patients treated with ...
Sung Joon Kim +5 more
doaj +1 more source
Modulation of 8-OH-DPAT-Induced Hypothermia by Imipramine in Rats
Journal of Pharmacological Sciences, 2003 : The effects of imipramine on 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), the 5-hydroxytryptamine (5-HT)1A-receptor full agonist, -induced hypothermia was examined in rats.
Yoshihisa Kitamura +4 more
doaj +1 more source