Results 21 to 30 of about 6,488,196 (247)

Pain relief devoid of opioid side effects following central action of a silylated neurotensin analog [PDF]

Eur J Pharmacol, 173174 (2020), 2020
Neurotensin (NT) exerts naloxone-insensitive antinociceptive action through its binding to both NTS1 and NTS2 receptors and NT analogs provide stronger pain relief than morphine on a molecular basis. Here, we examined the analgesic/adverse effect profile of a new NT(8-13) derivative denoted JMV2009, in which the Pro10 residue was substituted by a ...
arxiv   +1 more source

Targeted temperature management for ischemic stroke [PDF]

Journal of Neurocritical Care, 2019
Therapeutic hypothermia (TH) or targeted temperature management is an intentional cooling or temperature control technique using a thermostatic equipment (i.e., surface, endovascular, and focal devices) for specific therapeutic purposes.
Ji Man Hong
doaj   +1 more source

Cell-penetrating pepducins targeting the neurotensin receptor type 1 relieve pain [PDF]

Pharmacological Research. 104750 (2020), 2020
Pepducins are cell-penetrating, membrane-tethered lipopeptides designed to target the intracellular region of a G protein-coupled receptor (GPCR) in order to allosterically modulate the receptor's signaling output. In this proof-of-concept study, we explored the pain-relief potential of a pepducin series derived from the first intracellular loop of ...
arxiv   +1 more source

Successful fibrinolytic and therapeutic hypothermic management of cardiac arrest following massive pulmonary embolism [PDF]

Clinical and Experimental Emergency Medicine, 2015
Massive pulmonary embolism (MPE) with hemodynamic instability is a clinical condition with a poor prognosis and high mortality rates. There are no definitive treatment options for cardiac arrest due to MPE. A 52-year-old female presented at our emergency
Eunsil Ko, Jeong Hoon Lee, Minjung Kathy Chae, Tae Rim Lee, Min Seob Sim, Tae Gun Shin, Won Chul Cha, Ik Joon Jo, Keun Jeong Song, Joong Eui Rhee, Yeon Kwon Jeong   +10 more
doaj   +1 more source

Combined Cyclosporin A and Hypothermia Treatment Inhibits Activation of BV-2 Microglia but Induces an Inflammatory Response in an Ischemia/Reperfusion Hippocampal Slice Culture Model [PDF]

, 2019
Introduction: Hypothermia attenuates cerebral ischemia-induced neuronal cell death associated with neuroinflammation. The calcineurin inhibitor cyclosporin A (CsA) has been shown to be neuroprotective by minimizing activation of inflammatory pathways.
Berger, Felix, Krech, Jana, Rolfs, Nele, Schmitt, Katharina R. L., Tong, Giang, Wowro, Sylvia J.   +5 more
core   +1 more source

Effects of local hypothermia-rewarming on physiology, metabolism and inflammation of acutely injured human spinal cord. [PDF]

, 2020
In five patients with acute, severe thoracic traumatic spinal cord injuries (TSCIs), American spinal injuries association Impairment Scale (AIS) grades A-C, we induced cord hypothermia (33 °C) then rewarming (37 °C).
A Bricolo, A Mizuma, A Schubert, C Hochstim, DW Marion, GL Clifton, GV Varsos, HA Choi, I Phang, I Phang, JR Bethea, K Chatzipanteli, K Chatzipanteli, KL Carpenter, L Zhu, M Dididze, M Erecinska, MC Werndle, MC Werndle, MJ Gallagher, PE Batchelor, PJ Andrews, PJ Hutchinson, RR Hansebout, S Chen, S Saadoun, S Shibuya, SR Lewis, TP Lo Jr.   +28 more
core   +1 more source

Nitric oxide-mediated inhibition of phenylephrine-induced contraction in response to hypothermia is partially modulated by endothelial Rho-kinase

International Journal of Medical Sciences, 2020
This study examined the possible upstream cellular signaling pathway associated with nitric oxide (NO)-mediated inhibition of phenylephrine-induced contraction in isolated rat aortae in response to mild hypothermia, with a particular focus on endothelial
S. Lee, S. Ok, R. Subbarao, Ji-Yon Kim, S. Bae, Yeran Hwang, Seongyeong Tak, J. Sohn   +7 more
semanticscholar   +1 more source

Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia.

New England Journal of Medicine, 2002
BACKGROUND Cardiac arrest outside the hospital is common and has a poor outcome. Studies in laboratory animals suggest that hypothermia induced shortly after the restoration of spontaneous circulation may improve neurologic outcome, but there have been ...
Stephen A Bernard, T. Gray, Michael D. Buist, B. M. Jones, W. Silvester, G. Gutteridge, Karen Smith   +6 more
semanticscholar   +1 more source

Acute Physiologic and Chronic Health Examination II and Sequential Organ Failure Assessment Scores for Predicting Outcomes of Out-of-Hospital Cardiac Arrest Patients Treated with Therapeutic Hypothermia [PDF]

Korean Journal of Critical Care Medicine, 2014
BACKGROUND: The aim of this study was to assess the relationship between acute physiologic and chronic health examination (APACHE) II and sequential organ failure assessment (SOFA) scores and outcomes of post-cardiac arrest patients treated with ...
Sung Joon Kim, Yong Su Lim, Jin Seong Cho, Jin Joo Kim, Won Bin Park, Hyuk Jun Yang   +5 more
doaj   +1 more source

Therapeutic hypothermia and neurological outcome after cardiac arrest [PDF]

Vojnosanitetski Pregled, 2011
Introduction/Aim. The most important clinically relevant cause of global cerebral ischemia is cardiac arrest. Clinical studies showed a marked neuroprotective effect of mild hypothermia in resuscitation.
Petrović Milovan, Panić Gordana, Jovelić Aleksandra, Čanji Tibor, Srdanović Ilija, Popov Tanja, Golubović Miodrag   +6 more
doaj   +1 more source