Results 61 to 70 of about 6,425,252 (325)

AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells

Advanced Science, EarlyView.
Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu, Guisheng Chen, Rui Hu, Peiwen Liu, Jintao Lou, Wenji Zhao, Zuhong He, Suhua Sha, Yiqing Zheng   +8 more
wiley   +1 more source

The circadian system alters thermoregulation depending on the time of day and feeding condition [PDF]

, 2009
The circadian rhythm of body temperature (Tb) is a well-known phenomenon. However, it is unknown how the circadian system affects thermoregulation. Food deprivation in mice induces a greater reduction of Tb particularly in the light phase.
Kei Nagashima, Ken Tokizawa, Yuki Uchida
core   +1 more source

In Situ/Operando Probing of Dynamic Phase Structures of Alumina‐Supported Ultrasmall Copper‐Gold Alloy Nanoparticles Under Reaction Conditions

Angewandte Chemie, EarlyView.
Supported ultrasmall copper‐gold alloy nanoparticles are active heterogenous catalysts. In situ TEM tracking under oxygen at different temperatures reveals atomic‐scale dynamic phase structures, whereas combined operando synchrotron HE‐XRD and DRIFTS characterizations uncover ensemble‐averaged ordering/disordering phase structures and oscillatory ...
Han‐Wen Cheng, Jing Li, Shiyao Shan, Xiaowei Lv, Guanyu Chen, Merry Madiou, Dong Dinh, Seyed Danial Mousavi, Zhi‐Peng Wu, Shan Wang, Yazan Maswadeh, Valeri Petkov, Susan Lu, Ke Pei, Wenbin You, Renchao Che, Chuan‐Jian Zhong   +16 more
wiley   +2 more sources

Effect of hypothermia on haemostasis and bleeding risk: a narrative review

Journal of International Medical Research, 2019
It must be remembered that clinically important haemostasis occurs in vivo and not in a tube, and that variables such as the number of bleeding events and bleeding volume are more robust measures of bleeding risk than the results of analyses.
Thomas Kander, Ulf Schött
doaj   +1 more source

Induced Hypothermia for Acute Stroke [PDF]

Stroke, 2007
Induced hypothermia is one of the most promising neuroprotective therapies. Technological limitations and homeostatic mechanisms that maintain core body temperature have impeded the clinical use of hypothermia. Recent advances in intravascular cooling catheters and successful trials of hypothermia for cardiac arrest and neonatal asphyxia renewed ...
Patrick D. Lyden, Thomas M. Hemmen
openaire   +2 more sources

A novel scoring system for predicting the neurologic prognosis prior to the initiation of induced hypothermia in cases of post-cardiac arrest syndrome: the CAST score

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2017
BackgroundThe aim of this study was to develop a scoring system for identifying the post-cardiac arrest syndrome (PCAS) patients with a good potential for recovery prior to the initiation of induced therapeutic hypothermia.MethodsA multi-center ...
M. Nishikimi, N. Matsuda, Kota Matsui, Kunihiko Takahashi, T. Ejima, Keibun Liu, T. Ogura, M. Higashi, H. Umino, Go Makishi, A. Numaguchi, S. Matsushima, Hideki Tokuyama, Mitsunobu Nakamura, S. Matsui   +14 more
semanticscholar   +1 more source

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

Advanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei, Shiwei Qiu, Xue Gao, Lu Zheng, Yijin Chen, Ying Ma, Haifeng Feng, Jinyuan Yang, Guojie Dong, Huiyi Nie, Weihao Zhao, Xiaoge Li, Guangqin Wang, Wei Xiong, Pu Dai, Yongyi Yuan   +15 more
wiley   +1 more source

Scalp cooling with adjuvant/neoadjuvant chemotherapy for breast cancer and the risk of scalp metastases: systematic review and meta-analysis. [PDF]

, 2017
PurposeThe risk of scalp metastases in patients using scalp cooling for preservation of hair during chemotherapy has been a concern but is poorly described.MethodsA systematic review and meta-analysis of longitudinal studies was undertaken to evaluate ...
Melin, Susan A, Rugo, Hope S, Voigt, Jeff   +2 more
core   +1 more source

PD149163 induces hypothermia to protect against brain injury in acute cerebral ischemic rats

Journal of Pharmacological Sciences, 2017
Therapeutic hypothermia is a promising strategy for acute cerebral ischemia via physical or pharmacological methods. In this study, we pharmacologically induced hypothermia on Sprague Dawley rats by intraperitoneally injecting PD149163.
Teng-Fei Xue, Xu Ding, Juan Ji, Hui Yan, Ji-Ye Huang, Xu-Dong Guo, Jin Yang, Xiu-Lan Sun   +7 more
doaj   +1 more source

Long‐Lasting Auditory and Vestibular Recovery Following Gene Replacement Therapy in a Novel Usher Syndrome Type 1c Mouse Model

Advanced Science, EarlyView.
This study shows that gene replacement therapy using the AAV2/Anc80L65 virus can successfully restore hearing and balance in Ush1c knockout mice. The treatment leads to lasting improvements in both auditory and vestibular functions, highlighting its potential as a therapeutic approach for genetic hearing loss and vestibular disorders in humans ...
Weinan Du, Jun Huang, Aizhen Zhang, Fangfang Zhao, Tianwen Chen, Quinn M. McDermott, Tony Zheng, Haibo Wang, Rongli Zhang, Xiaolin Zhang, Jerome Allison, Hong Zhu, Wu Zhou, Qing Yin Zheng   +13 more
wiley   +1 more source