Results 41 to 50 of about 153,410 (301)

Cell-penetrating pepducins targeting the neurotensin receptor type 1 relieve pain [PDF]

Pharmacological Research. 104750 (2020), 2020
Pepducins are cell-penetrating, membrane-tethered lipopeptides designed to target the intracellular region of a G protein-coupled receptor (GPCR) in order to allosterically modulate the receptor's signaling output. In this proof-of-concept study, we explored the pain-relief potential of a pepducin series derived from the first intracellular loop of ...
arxiv   +1 more source

Treatment of Neonatal Hypoxic-Ischemic Encephalopathy with Erythropoietin Alone, and Erythropoietin Combined with Hypothermia: History, Current Status, and Future Research

International Journal of Molecular Sciences, 2020
Perinatal hypoxic-ischemic encephalopathy (HIE) remains a major cause of morbidity and mortality. Moderate hypothermia (33.5 °C) is currently the sole established standard treatment.
D. Oorschot, R. J. Sizemore, Ashraf R Amer   +2 more
semanticscholar   +1 more source

Research status and hotspots of hypothermia and human diseases: a bibliometric analysis. [PDF]

Front Med (Lausanne)
BackgroundHypothermia has been strongly associated with human diseases; it affects life safety. Therapeutic hypothermia generates good results for certain diseases, without serious complications.
Li WX, Han NN, Ji QY, Dong XT, Lu CL, Wang SJ.   +5 more
europepmc   +2 more sources

Neuroprotective Role of Hypothermia in Acute Spinal Cord Injury

Biomedicines, 2022
Even nowadays, the question of whether hypothermia can genuinely be considered therapeutic care for patients with traumatic spinal cord injury (SCI) remains unanswered.
Hasan Al-Nashash, Angelo H. ALL
doaj   +1 more source

Neonatal hypothermia in Northern Uganda: a community-based cross-sectional study

BMJ Open, 2021
Objective To determine the prevalence, predictors and case fatality risk of hypothermia among neonates in Lira district, Northern Uganda.Setting Three subcounties of Lira district in Northern Uganda.Design This was a community-based cross-sectional study
Milton W Musaba, Grace Ndeezi, Thorkild Tylleskär, David Mukunya, James K Tumwine, Victoria Nankabirwa, Beatrice Odongkara, Justin B Tongun, Agnes A Arach, Josephine Tumuhamye, Agnes Napyo, Vivian Zalwango, Vicentina Achora   +12 more
doaj   +1 more source

Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients With Severe Traumatic Brain Injury: The POLAR Randomized Clinical Trial

Journal of the American Medical Association (JAMA), 2018
Importance After severe traumatic brain injury, induction of prophylactic hypothermia has been suggested to be neuroprotective and improve long-term neurologic outcomes.
D. J. Cooper, A. Nichol, M. Bailey, S. Bernard, Peter A. Cameron, S. Pili-Floury, A. Forbes, D. Gantner, Alisa M. Higgins, O. Huet, J. Kasza, L. Murray, L. Newby, Jeffrey J. Presneill, S. Rashford, Jeffrey V. Rosenfeld, M. Stephenson, S. Vallance, D. Varma, Steven A R Webb, T. Trapani, C. McArthur   +21 more
semanticscholar   +1 more source

Hypothermia and its role in patients with ST-segment-elevation myocardial infarction and cardiac arrest

Frontiers in Cardiovascular Medicine, 2022
BackgroundPatients suffering cardiac arrest resulting from ST-segment-elevation myocardial infarction (STEMI) are at very high risk of death. In addition to reperfusion strategies, therapeutic hypothermia is recommended for cardiac arrest patients who ...
Karsten Keller, Karsten Keller, Karsten Keller, Ingo Sagoschen, Volker H. Schmitt, Volker H. Schmitt, Thomas Münzel, Thomas Münzel, Tommaso Gori, Tommaso Gori, Tommaso Gori, Lukas Hobohm, Lukas Hobohm   +12 more
doaj   +1 more source

Two-Year Neurodevelopmental Outcomes After Mild Hypoxic Ischemic Encephalopathy in the Era of Therapeutic Hypothermia.

JAMA pediatrics, 2019
Importance Therapeutic hypothermia reduces risk of death and disability in infants with moderate to severe hypoxic ischemic encephalopathy (HIE). Randomized clinical trials of therapeutic hypothermia to date have not included infants with mild HIE ...
M. Finder, G. Boylan, D. Twomey, C. Ahearne, D. Murray, B. Hallberg   +5 more
semanticscholar   +1 more source

Randomized preclinical study of machine perfusion in vascularized composite allografts

BJS (British Journal of Surgery), EarlyView., 2020
This study was designed to identify the optimum machine perfusion parameters for preservation of limbs before transplantation, and determine whether this was better than cold storage. Normothermic machine perfusion at a pressure of 70 mmHg (NMP‐70) provided superior preservation to cold storage after transplantation.
K. R. Amin, J. P. Stone, J. Kerr, A. Geraghty, L. Joseph, A. Montero‐Fernandez, J. K. Wong, J. E. Fildes   +7 more
wiley   +1 more source

Therapeutic Hypothermia after Decompressive Craniectomy in Malignant Cerebral Infarction [PDF]

Korean Journal of Critical Care Medicine, 2014
Decompressive hemicraniectomy followed by subsequent therapeutic hypothermia can reduce mortality in patients with malignant cerebral infarction without significantly increasing risk.
Jun Young Chang, Jeong Ho Hong, Jin Heon Jeong, Sung Jin Nam, Ji Hwan Jang, Jae Seung Bang, Moon Ku Han   +6 more
doaj   +1 more source