Results 91 to 100 of about 193,493 (202)

Progress Toward a Portable Artificial Lung: A Systematic Review

Artificial Organs, EarlyView.
Eight portable respiratory assist devices were identified. The CE‐marked MobyBox and the FDA‐approved Breethe OXY‐1 system are in clinical use. Each device is substantially minimized to allow ambulation, but further work is required to address challenges related to anticoagulant management and safe mobilization. Created in BioRender. Svendsen, A. (2026)
Maja Munk Svendsen, Clara Kjær Hendriksen, Lars Folkersen, Peter Juhl‐Olsen, Leila Louise Benhassen, Søren Nielsen Skov   +5 more
wiley   +1 more source

Hypothermic Oxygenated Perfusion (HOPE) downregulates the immune response in a rat model of liver transplantation [PDF]

, 2014
OBJECTIVE: To evaluate the impact of a novel oxygenated perfusion approach on rejection after orthotopic liver transplantation (OLT). BACKGROUND: Hypothermic oxygenated perfusion (HOPE) was designed to prevent graft failure after OLT.
Kron, Philipp, Philipp Dutkowski, Schlegel, Andrea, Clavien, Pierre-Alain, Dutkowski, Philipp, Andrea Schlegel, Rolf Graf, Pierre-Alain Clavien, Philipp Kron, Graf, Rolf   +9 more
core   +1 more source

Hypothermic Oxygenated Machine Perfusion in Donor Hearts

Heart transplantation remains the definitive treatment for end-stage heart diseases. The rising demand for heart transplants underscores the need to expand the donor pool by using marginal and long-distant donors with the potential of increasing the rate of primary graft dysfunction.
Nafiye Busra Celik, Mohammad Alomari, Vivienne Pham, Pankaj Garg, Si Pham   +4 more
openaire   +1 more source

The Anti‐Inflammatory Effect of Normothermic Machine Perfused Human Kidneys on Monocyte‐Derived Dendritic Cells

Artificial Organs, EarlyView.
The immunogenicity of donor kidneys on NMP can be studied using monocyte‐derived dendritic cells. Incubation with perfusate showed an anti‐inflammatory dendritic cell phenotype and function that suggests the release of an anti‐inflammatory factor or factors during NMP. ABSTRACT Background The immunomodulatory activity of normothermic machine perfusion (
Laura W. D. Knijff, Asel S. Arykbaeva, Sandra W. van der Kooij, Dorottya K. de Vries, Mieke F. van Essen, Ian P. J. Alwayn, Henri G. D. Leuvenink, Rutger J. Ploeg, Cees van Kooten   +8 more
wiley   +1 more source

Nationwide Hypothermic Machine Perfusion for ECD and DCD Kidney Transplantation in Belgium: One-Year Outcomes and Impact on Transplant Rates and Budget Impact Analysis

Transplant International
In September 2022, Belgium implemented a nationally reimbursed HMP service for all ECD and DCD kidneys procured and transplanted within the country. We retrospectively analyzed data from 242 kidney transplantations preserved with continuous HMP between ...
Tom Darius, Ina Jochmans, Maxime Foguenne, Eric Hoste, Caren Randon, Bart Bracke, Geert Roeyen, Nicholas Gilbo, Laurent Weekers, Daniel Jacobs-Tulleneers-Thevissen, Karl Martin Wissing, Tineke Bogaerts, Dimitri Mikhalski, jean-Philippe De Wilde, Joël Daems, Jacques Pirenne   +15 more
doaj   +1 more source

Heart Donation After Controlled Circulatory Death in Noncardiac Surgery Hospitals With a Mobile Heart Team: A Case Series From an Italian Regional Program and Integrated Review of the Literature

Artificial Organs, EarlyView.
In this series of 19 DCD donors using TA‐NRP, 89.5% of hearts were successfully transplanted with no PGD, no postoperative ECMO, and no 30‐day mortality, demonstrating the feasibility and safety of this approach. ABSTRACT Controlled donation after circulatory death (cDCD) with thoracoabdominal normothermic regional perfusion (TA‐NRP) has emerged ...
Maria Benedetto, Valentina Roncarati, Arianna Campana, Erika Cordella, Domenico Nocera, Sofia Martin‐Suarez, Luca Botta, Davide Pacini, Letizia Perinati, Massimo Baiocchi, Tommaso Tonetti, Fabrizio Monaco   +11 more
wiley   +1 more source

Current Insights into the Metabolome during Hypothermic Kidney Perfusion—A Scoping Review

, 2023
This scoping review summarizes what is known about kidney metabolism during hypothermic perfusion preservation. Papers studying kidney metabolism during hypothermic (
Ghesquière, Bart, Ina Jochmans, Laurence Verstraeten, Verstraeten, Laurence, Rutger Den abt, Den abt, Rutger, Bart Ghesquière, Jochmans, Ina   +7 more
core   +1 more source

Impact of Respiratory Support Strategies on CO2 Variability During Therapeutic Hypothermia in Neonates With Asphyxia: Data From the German Hypothermia Registry

Acta Paediatrica, EarlyView.
ABSTRACT Aim To evaluate associations between respiratory support strategies, partial pressure of carbon dioxide (pCO2) variability and oxygen exposure in neonates with hypoxic–ischaemic encephalopathy (HIE) undergoing therapeutic hypothermia (TH). Methods This retrospective multicentre study used data from the German Hypothermia Registry, including ...
Sebiha Demir, Anne Groteklaes, Bettina Bohnhorst, Kirsten Glaser, Andreas Müller, Hemmen Sabir, Till Dresbach, on behalf of the German Hypothermia Registry, Milian Brasche, Nicolas Allgaier, Daniel Klotz, Norbert Teig, Katja Schneider, Hemmen Sabir, Sandra Holz, Birte Tröger, Thorsten Körner, Uwe Höpner, Marie Schmenk, Michael Hofmann, Mario Rüdiger, Julia Osterholt, Martin Berghäuser, Christopher Willerscheidt, Farina Morgenroth, Hans Jörg Bittrich, Steven Hébert, Arber Arapi, Anja Stein, Veit Lange, Gunnar Rau, Lisa‐Marie Stoek, Nikolas Hillenbrand, Matthias Reger, Susanne Schade, Jana Dieks, Heimke von Osten, Marita Horstkemper, Martin Blohm, Mario Lange, Bettina Bohnhorst, Manuela Friederike Richter, Simon Kranig, Maurice Petrasch, Nasenien Nourkami‐Tutdibi, Christine Pinkwart, Thomas Kriebel, Silvia Welcker, Nora Bonney, Angela Kribs, Clemens Andrée, Sophia Stadermann, Kirsten Glaser, Peter Jahn, Katrin Braun, Anna Eisenhardt, Alba Perez‐Ortiz, Nadine Mand, Ines Wallot, Timea Takacs, Anja Jäger, Oliver Schroers, Esther Schouten, Claudia Nussbaum, Kai Böckenholt, Rüdiger Wentzell, Guido Engelmann, Katherine Louise Kastor, Michael Schroth, Matthias Engler, Friederike Eichhorn, Moritz Rohrbach, Fabian Bärtling, Frank Dohle, Matthias Keller, Marion Weber, Verena Lehnerer, Anja Mayer, Marie‐Claire Detemple, Valentin Oellers, Markus Pingel, Friederike Eilbracht, Jutta Adler, Elena Eberle, Karoline Goj, Virginia Toth, Andrea Czoske, Cornelia Wiechers, Christiane Mayer, Anja Schumann, Patrick Salaschek, Janaina Rauch, Kai Hensel, Pia Paul   +93 more
wiley   +1 more source

Hypothermic Oxygenated Perfusion To Reduce Tumour Recurrence After Liver Transplantation In Patients With Hepatocarcinoma

, 2022
Hypothermic oxygenated ex-situ machine perfusion (HOPE) is a dynamic preservation method that has been developed to reduce the incidence and severity of ischaemia-reperfusion injury and to improve outcomes after liver transplantation.
matteo ravaioli
core   +1 more source

Transplantation of high-risk donor livers after resuscitation and viability assessment using a combined protocol of oxygenated hypothermic, rewarming and normothermic machine perfusion: study protocol for a prospective, single-arm study (DHOPE-COR-NMP trial)

BMJ Open, 2019
Introduction Extended criteria donor (ECD) livers are increasingly accepted for transplantation in an attempt to reduce the gap between the number of patients on the waiting list and the available number of donor livers.
Yvonne de Vries, Tim A Berendsen, Masato Fujiyoshi, Aad P van den Berg, Hans Blokzijl, Marieke T de Boer, Frans van der Heide, Ruben H J de Kleine, Otto B van Leeuwen, Alix P M Matton, Maureen J M Werner, Ton Lisman, Vincent E de Meijer, Robert Porte   +13 more
doaj   +1 more source