Results 81 to 90 of about 193,493 (202)

Dual acellular subnormothermic machine perfusion for enhanced uterus preservation in a swine model

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
In a porcine uterus transplantation model, subnormothermic machine perfusion reduced graft edema and better‐preserved post‐reperfusion contractility than static cold storage, highlighting its potential for uterus preservation, assessment, and future graft‐conditioning applications.
Lucile Cabanel, Haïzam Oubari, Bradley W. Ellis, Ludivine Dion, Vincent Lavoué, Carla Sousa, Loïc Van Dieren, Olivier Morel, Mark A. Randolph, Curtis L. Cetrulo Jr., Korkut Uygun, Alexandre G. Lellouch, Yanis Berkane, Basak E. Uygun   +13 more
wiley   +1 more source

Detection of ATP by "in line" 31P magnetic resonance spectroscopy during oxygenated hypothermic pulsatile perfusion of pigs' kidneys

, 2012
To demonstrate that adenosine triphosphate (ATP), which provides a valuable biomarker for kidney viability in the context of donation after cardiac death (DCD) transplantation, can be detected by means of (31)P magnetic resonance spectroscopy (MRS) if ...
Hergt, Martin, Lazeyras, François, Morel, Philippe, Vallée, Jean-Paul, Ruttimann, Raphael, Buchs, Jean-Bernard, Buehler, Leo Hans, Nastasi, Antonio   +7 more
core   +1 more source

Oxygenated Hypothermic Machine Perfusion After Static Cold Storage Improves Hepatobiliary Function of Extended Criteria Donor Livers

, 2016
BACKGROUND: The mechanism through which oxygenated hypothermic machine perfusion (HMP) improves viability of human extended criteria donor (ECD) livers is not well known.
Matton, Alix P M, Gouw, Annette S H, van Rijn, Rianne, Leuvenink, Henri G D, Westerkamp, Andrie C, Porte, Robert J, Boer, de, Marieke T., Mahboub, Paria, Lisman, Ton; id_orcid, Lisman, Ton, Leuvenink, Henri G D; id_orcid, Karimian, Negin, Boer, de, Marieke T.; id_orcid, Wiersema-Buist, J.   +13 more
core   +1 more source

Revolutionizing Donor Heart Procurement: Innovations and Future Directions for Enhanced Transplantation Outcomes

Journal of Cardiovascular Development and Disease
Heart failure persists as a critical public health challenge, with heart transplantation esteemed as the optimal treatment for patients with end-stage heart failure.
Marc Leon
doaj   +1 more source

Monitoring Mitochondrial Function With High‐Resolution Respirometry During Ex‐Situ Heart Perfusion

Artificial Organs, EarlyView.
Normothermic ESHP preserves mitochondrial respiratory function over 6 h in a porcine model (n = 6): OXPHOS capacities across NADH‐, fatty‐acid‐, and succinate‐linked pathways remain stable, with reduced cytochrome‐c control efficiency indicating improved outer‐membrane integrity. HRR provides a rapid, actionable readout for organ assessment.
Lukas Stastny, Julia Hofmann, Andras T. Meszaros, Alexandra Ampferer, Gabriel Putzer, Nina Perkins, Natalie Huemer, Florian Sommerauer, Judith Martini, Julian Wagner, Michael Grimm, Stefan Schneeberger, Julia Dumfarth   +12 more
wiley   +1 more source

Experimental study on coronary perfusion with selective brain cooling for direct aortic surgery [PDF]

, 1959
1. Retrograde coronary perfusion in combination with selective brain cooling by irrigation was investigated in dogs, in comparison with direct coronary artery perfusion. 2.
Hayashi, Naomi
core   +1 more source

Experimental Extracorporeal Circulation System: A Pilot Study in Rats

Artificial Organs, EarlyView.
A miniature extracorporeal circulation (ECC) system was developed for reproducible rodent studies. This system incorporates an integrated heat exchanger and a silicone membrane oxygenator within a double‐lumen circuit, resulting in an ultralow priming volume of < 1.5 mL.
Akira T. Kawaguchi, Kaori Inukai, Mayuko Shibata, Gen T. Kawaguchi, Kazuaki Sato, Taiga Aburaya, Jacob Bergsland, Yoshiyuki Yamada   +7 more
wiley   +1 more source

Combined Hypothermic and Normothermic Machine Perfusion Improves Functional Recovery of Extended Criteria Donor Livers [PDF]

, 2018
Hypothermic oxygenated perfusion (HOPE) and normothermic perfusion are seen as distinct techniques of ex situ machine perfusion of the liver. We aimed to demonstrate the feasibility of combining both techniques and whether it would improve functional ...
Darius F. Mirza, Afford, Simon C, Wallace, Lorraine, Hynek Mergental, Mirza, Darius F, Andrea Schlegel, Attard, Joseph, Laing, Richard W, Joseph Attard, Richard W. Laing, M. Thamara P. R. Perera, Simon C. Afford, Bhogal, Ricky H, Desley A. H. Neil, Smith, Amanda, Yuri L. Boteon, Stefan Hübscher, Neil, Desley A H, Hübscher, Stefan, Ricky H. Bhogal, Boteon, Yuri L, Perera, M Thamara P R, Mergental, Hynek, Amanda Smith, Schlegel, Andrea, Lorraine Wallace   +25 more
core   +1 more source

Successful Dual Kidney Transplantation After Hypothermic Oxygenated Perfusion of Discarded Human Kidneys. [PDF]

Am J Case Rep, 2017
BACKGROUND The recovery of discarded human kidneys has increased in recent years and impels to use of unconventional organ preservation strategies that improve graft function.
Ravaioli M, De Pace V, Comai G, Busutti M, Del Gaudio M, Amaduzzi A, Cucchetti A, Siniscalchi A, La Manna G, D'Errico AAD, Pinna AD.   +10 more
europepmc   +3 more sources

Mono-HOPE Versus Dual-HOPE in Liver Transplantation: A Propensity Score-Matched Evaluation of Early Graft Outcome

Transplant International
Hypothermic oxygenated machine perfusion (HOPE) has become an integral technique to enhance donor graft function in liver transplantation (LiTx). This study compares early posttransplant outcomes of mono-HOPE (portal vein perfusion only) versus dual ...
Dominik Thomas Koch, Dominik Thomas Koch, Micol Tamai, Malte Schirren, Malte Schirren, Moritz Drefs, Moritz Drefs, Severin Jacobi, Severin Jacobi, Christian M. Lange, Christian M. Lange, Matthias Ilmer, Matthias Ilmer, Matthias Ilmer, Hanno Nieß, Hanno Nieß, Bernhard Renz, Bernhard Renz, Jens Werner, Jens Werner, Markus Guba, Markus Guba, Dionysios Koliogiannis, Dionysios Koliogiannis   +23 more
doaj   +1 more source