Results 51 to 60 of about 193,493 (202)

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Printing‐Assisted Integration of Thermal, Fluidic and Electrical Components in Implants for Focal Brain Cooling

Advanced Science, EarlyView.
Extrusion‐based 3D printing of silicones and discrete electronic components are combined to create cortical implants for rodents that integrate thermal neuromodulation and electrical recording. Linked to an autonomous auxiliary driver unit, the system enables rapid, stable and localized hypothermia alongside ECoG recording.
Spencer Ryan Moore, Naomi King, Aruã Clayton Da Silva, Clare Howarth, Jason Berwick, Thomas E. Paterson, Ivan R. Minev   +6 more
wiley   +1 more source

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

Hypothermic oxygenated machine perfusion in porcine donation after circulatory determination of death liver transplant.

, 2012
BACKGROUND: Livers from donation after circulatory determination-of-death (DCD) donors suffer ischemic injury during a preextraction period of cardiac arrest and are infrequently used for transplantation; they have the potential, however, to considerably
Hessheimer, AJ, Garcia-Valdecasas, Juan C., Calatayud, David, Muñoz, J, Calatayud, D, Leuvenink, Henri, Fondevila, C, Rimola, A, Rimola, Antoni, Taura, Pilar, Leuvenink, Henri; id_orcid, García-Valdecasas, JC, Leuvenink, H, Ploeg, Rutger, Taurá, P, Hessheimer, Amelia J., Maathuis, MH, Fondevila, Constantino, Maathuis, Mark-Hugo J., Munoz, Javier, Ploeg, Rutger J.   +20 more
core   +1 more source

Advances in Kidney Transplant, Machine Perfusion, and Viability Markers

Kidney and Dialysis
Despite improvements in kidney transplantation rates, the shortage of donor kidneys remains a critical issue, exacerbated by non-utilization of recovered kidneys due to quality concerns, necessitating advancements in perfusion methods to enhance graft ...
Stephanie Y. Ohara, Mariana Chavez-Villa, Shennen Mao, Jacob Clendenon, Julie Heimbach, Randi Ryan, Lavanya Kodali, Michelle C. Nguyen, Rafael Nateras-Nunez, Caroline C. Jadlowiec   +9 more
doaj   +1 more source

1,2‐propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia

Animal Models and Experimental Medicine, EarlyView.
This study develops a reformulated tribromoethanol (TBE) anesthetic using 1,2‐propanediol as a solvent to overcome solvent‐related toxicity. The novel formulation demonstrates, cardiovascular stability, and survival in prolonged protocols. It provides potent, dose‐dependent anesthesia without strain or sex differences.
Xia Li, Yanming Chen, Xinyi Xiao, Guoheng Xu   +3 more
wiley   +1 more source

Evaluation of the prospects for developing a next-generation perfusion solution for hypothermic oxygenated preservation of donor organs

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье
Background. Ischemia-reperfusion injury remains a central challenge in clinical transplantology, determining outcomes particularly when using organs from expanded criteria donors and donors after circulatory death.
M. S. Novruzbekov, B. I. Yaremin, A. G. Balkarov, B. I. Kazymov, P. O. Svischeva, O. N. Pavlova, S. M. Khanova   +6 more
doaj   +1 more source

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

British Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

Machine perfusion for liver transplantation: opportunities and challenges for the next generation of transplant surgeons

Frontiers in Transplantation
Machine perfusion is reshaping liver transplantation by turning preservation from passive storage into an active, physiologic intervention. This review synthesizes randomized and real-world evidence on hypothermic oxygenated and normothermic approaches ...
Cody L. Mullens, Cody L. Mullens, Cody L. Mullens, Kumaran Shanmugarajah, Glenn K. Wakam   +4 more
doaj   +1 more source

Hypothermic oxygenated perfusion - initial experience [PDF]

HPB, 2021
J. Constantino, P. Oliveira, R. Martins, A. Pinho, E. Furtado, J.G. Tralhão, D. Diogo   +6 more
openaire   +1 more source