Results 41 to 50 of about 56,557 (212)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Efficacy of Sodium Phenylbutyrate–Taurursodiol in Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis

Annals of Indian Academy of Neurology
Objective: To evaluate the efficacy and safety of sodium phenylbutyrate–taurursodiol (PB–TURSO) and its components in slowing disease progression and improving survival in patients with amyotrophic lateral sclerosis (ALS).
Abdulkareem M Jomaa, Haseeba Khalid, Halder J Abozait, Hammad Mudassar, Ravneet Kaur   +4 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Overall compilation of adverse effects of non-steroidal anti-inflammatory drugs: a hypothesis-free systematic investigation using a nationwide cohort study

Frontiers in Pharmacology
BackgroundNon-steroidal anti-inflammatory drugs (NSAIDs) are widely used for osteoarthritis (OA), despite various adverse effects (AEs). Previous studies were often limited by small sample sizes, a focus on only predefined outcomes, and an imbalanced ...
Hyein Han, Du Hyun Ro, Du Hyun Ro, Du Hyun Ro, Du Hyun Ro, Hyuk-Soo Han, Hyuk-Soo Han, Sungho Won, Sungho Won, Sungho Won, Sungho Won   +10 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Prophylactic endoluminal vacuum therapy after total laryngectomy or laryngopharyngectomy: a retrospective propensity score-matched cohort study

American Journal of Otolaryngology
Objective: To evaluate the impact of prophylactic endoluminal vacuum-assisted closure (EndoVAC) on pharyngocutaneous fistula (PCF) incidence and duration of hospitalization following total laryngectomy (TL) or laryngopharyngectomy (LP).
Eun Kyung Jung, Juwon Hwang, Hyunjun Jung, Hye-Bin Jang, Joon Kyoo Lee   +4 more
doaj   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Effectiveness of beetroot juice on aerobic and anaerobic exercise performance: systematic review and meta-analysis

Frontiers in Nutrition
PurposeBeetroot juice (BJ), a natural source of dietary nitrate, has been widely studied for its potential ergogenic effects; however, evidence integrating both aerobic and anaerobic performance outcomes remains limited.
Chengcheng Cai, Peijun Huang, Xiaolei Cheng, Jinghui Zhou   +3 more
doaj   +1 more source