Results 41 to 50 of about 248,739 (243)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Confirmation Bias: The Pitfall of Forensic Science [PDF]

, 2013
As it stands, forensic science and its practitioners are held in high regard in criminal court proceedings due to their ability to discover irrefutable facts that would otherwise go unnoticed.
Moser, Scott
core   +1 more source

The Search for Invariance: Repeated Positive Testing Serves the Goals of Causal Learning [PDF]

, 2020
Positive testing is characteristic of exploratory behavior, yet it seems to be at odds with the aim of information seeking. After all, repeated demonstrations of one’s current hypothesis often produce the same evidence and fail to distinguish it from ...
A Coenen, A Gopnik, A Gopnik, A Gopnik, A Gopnik, A Karmiloff-Smith, AM Johnston, B Inhelder, B Schwartz, B Sodian, B Weslake, C Cook, C Hitchcock, C Zimmerman, C Zimmerman, C Zimmerman, CM Walker, CRM McKenzie, D Klahr, D Klahr, D Klahr, D Kuhn, D Kuhn, D Kuhn, D Lewis, DD Tukey, DJ Navarro, EB Bonawitz, GD Heyman, GL Wells, HJ Einhorn, J Baron, J Friedrich, J Klayman, J Woodward, J Woodward, J Woodward, J Woodward, JE Tschirgi, JJ Gibson, JL Mackie, JR Saffran, K Dunbar, KS Kendler, L Schauble, L Schauble, L Schauble, M Friedman, M Oaksford, M Redhead, M Strevens, ME Gorman, MJ Mahoney, N Valanides, N Vasilyeva, NE Wetherick, P Kitcher, P Ylikoski, PC Wason, PC Wason, PC Wason, PC Wason, PG Devine, PN Johnson-Laird, R Vogel, R Wu, RB Skov, RD Tweney, RS Nickerson, RS Siegler, S Carey, S Carey, S Croker, SA Gelman, SA Siler, SA Sloman, SA Sloman, SA Sloman, SC Yang, T Blanchard, T Gerstenberg, T Lombrozo, TF Icard, TJP Schijndel van   +83 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Two Aspects of Bias in Multivariate Studies: Mixing Specific with General Concepts and “Comparing Apples and Oranges”

Montenegrin Journal of Sports Science and Medicine, 2014
This paper presents two types of bias that occur relatively often when using multivariate analysis. For both types of bias, it is characteristic that the number and choice of different types of variables are not balanced by application of clear ...
Joško Sindik
doaj  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Measuring Online Social Bubbles [PDF]

, 2015
Social media have quickly become a prevalent channel to access information, spread ideas, and influence opinions. However, it has been suggested that social and algorithmic filtering may cause exposure to less diverse points of view, and even foster ...
Flammini, Alessandro, Menczer, Filippo, Nikolov, Dimitar, Oliveira, Diego F. M.   +3 more
core   +3 more sources