Results 51 to 60 of about 248,739 (243)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

The why's the limit: curtailing self-enhancement with explanatory introspection

, 2007
Self-enhancement is linked to psychological gains (e.g., subjective well-being, persistence in adversity) but also to intrapersonal and interpersonal costs (e.g., excessive risk taking, antisocial behavior).
Gregg, Aiden P., Horton, Robert S., Sedikides, Constantine   +2 more
core   +1 more source

Confirmation of the existence of coherent orientations of quasar polarization vectors on cosmological scales [PDF]

, 2000
In order to verify the existence of coherent orientations of quasars polarization vectors on very large scales, we have obtained new polarization measurements for a sample of quasars located in a given region of the three-dimensional Universe where the ...
Axon, Battaner, Berriman, Brotherton, D. Hutsemékers, Gnedin, Gnedin, H. Lamy, Harari, Heiles, Hewitt, Hutsemékers, Hutsemékers, Hutsemékers, Impey, Impey, Jaaniste, Lamy, Lehmacher, Mathewson, Moore, Reinhardt, Rusk, Schmidt, Stockman, Vallée, Visvanathan, Wasserman, West, West   +29 more
core   +3 more sources

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Overall compilation of adverse effects of non-steroidal anti-inflammatory drugs: a hypothesis-free systematic investigation using a nationwide cohort study

Frontiers in Pharmacology
BackgroundNon-steroidal anti-inflammatory drugs (NSAIDs) are widely used for osteoarthritis (OA), despite various adverse effects (AEs). Previous studies were often limited by small sample sizes, a focus on only predefined outcomes, and an imbalanced ...
Hyein Han, Du Hyun Ro, Du Hyun Ro, Du Hyun Ro, Du Hyun Ro, Hyuk-Soo Han, Hyuk-Soo Han, Sungho Won, Sungho Won, Sungho Won, Sungho Won   +10 more
doaj   +1 more source

Hypotheses in Marketing Science: Literature Review and Publication Audit [PDF]

, 2001
We examined three approaches to research in marketing: exploratory hypotheses, dominant hypothesis, and competing hypotheses. Our review of empirical studies on scientific methodology suggests that the use of a single dominant hypothesis lacks ...
Armstrong, J. Scott, Brodie, Roderick J., Parsons, Andrew G.   +2 more
core   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Learning to be Biased [PDF]

We simulate societal opinion dynamics when there is confirmation bias in information gathering and spread. If decision making is influenced by confirmation bias, the agent puts more weight on positive information to confirm hypothesis or reservation in ...
Ch'ng, Kean Siang, Zaharim, Norzarina
core   +1 more source

A Logical Defence of Maher's Model of Polythematic Delusions [PDF]

, 2010
We proceed to describe a model for the formation and maintenance of polythematic delusions encountered in schizophrenia, which is in adequacy with Brendan Maher's account of delusions.
Franceschi, Paul
core