Hypouricemia and Urate Transporters
Biomedicines, 2022 Hypouricemia is recognized as a rare disorder, defined as a serum uric acid level of 2.0 mg/dL or less. Hypouricemia is divided into an overexcretion type and an underproduction type.
Naoyuki Otani +2 more
exaly +3 more sources
Genotype-Informed Characterization of Mild Renal Hypouricemia [PDF]
Kidney International ReportsIntroduction: Renal hypouricemia is caused by pathogenic variants in SLC22A12 and SLC2A9 . Current diagnostic thresholds based on serum uric acid (UA) (SUA < 2 mg/dl) and fractional excretion of UA (FEUA > 10%) may overlook individuals with monoallelic ...
Noa Carrera +10 more
doaj +2 more sources
Differential associations of transient hyperuricemia and transient hypouricemia with annual changes in estimated glomerular filtration rate in healthy participants: an observational study [PDF]
BMC NephrologyBackground Dysuricemia, encompassing both hyperuricemia (serum uric acid: SUA > 7 mg/dl) and hypouricemia (SUA ≤ 3 mg/dL), has been linked to cardio-renal risks, but it remains unclear whether consistent or transient dysuricemia contributes to the risk ...
Naoyuki Otani +7 more
doaj +2 more sources
Medicina (Lithuania), 2019 Background and objectives: There is insufficient epidemiological knowledge of hypouricemia. In this study, we aimed to describe the distribution and characteristics of Japanese subjects with hypouricemia.
Kazuki Ide, Koji Kawakami, Tomoko Usui
exaly +3 more sources
Biomedicines, 2022 Renal hypouricemia is a disease caused by the dysfunction of renal urate transporters. This disease is known to cause exercise-induced acute kidney injury, but its mechanism has not yet been established.
Ivan Sebesta +2 more
exaly +3 more sources
First case report of hypouricemia associated with adjuvant imatinib therapy in a patient with small intestinal gastrointestinal stromal tumor [PDF]
Frontiers in OncologyImatinib, a tyrosine kinase inhibitor, is primarily used for the treatment of chronic myeloid leukemia and gastrointestinal stromal tumors (GIST). The most common adverse events include peripheral edema, mild nausea, vomiting, diarrhea, myalgia, muscle ...
Juan Bu +4 more
doaj +2 more sources
Exercise-Induced Acute Kidney Injury in a Police Officer With Hereditary Renal Hypouricemia
Case Reports in Nephrology and Dialysis, 2019 Hereditary renal hypouricemia is characterized by hypouricemia with hyper-uric acid clearance due to a defect in renal tubular transport. Patients with hereditary renal hypouricemia have a higher risk of exercise-induced acute kidney injury (EAKI) and ...
Yoshio Shimizu +2 more
exaly +3 more sources
Clinical and genetic analysis of MOCOS gene-related hypouricemia [PDF]
Frontiers in GeneticsBackgroundUric acid is an important metabolic end-product in the human body, and metabolic abnormalities involving uric acid are receiving increasing attention.MethodsThis study involved clinical assessment and genetic testing of a 40-year-old male ...
Huifang Peng +7 more
doaj +2 more sources
Uric Acid Extremes and Lipid Dysregulation: Evidence from a Large Population-Based Study [PDF]
MetabolitesBackground: Uric acid (UA) exhibits a dual role, with anti-oxidant or pro-oxidant effects determined by its concentration. However, its association with lipid metabolism across different uric acid states remains unclear.
Yazeed Alshuweishi +3 more
doaj +2 more sources
Hypouricemia in Behçet’s Syndrome: Prevalence and Clinical Outcomes [PDF]
MedicinaBackground and Objectives: Behçet’s syndrome (BS) is a systemic inflammatory disorder characterized by recurrent oral and genital ulcers, uveitis, and vascular involvement. Serum uric acid (SUA) has been implicated in various inflammatory conditions, due
Burak Oz +3 more
doaj +2 more sources