Results 111 to 120 of about 17,899 (259)

Physiological levels of folic acid reveal purine alterations in Lesch-Nyhan disease [PDF]

, 2020
Lesch-Nyhan disease (LND), caused by a deficient salvage purine pathway, is characterized by severe neurological manifestations and uric acid overproduction.
Fu, Rong, Jinnah, H. A., López Blanco, José Manuel, Outtrim, Esther L., Sutcliffe, Diane J., Torres, Rosa J., Universitat Autònoma de Barcelona. Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular   +6 more
core   +1 more source

Metabolic and neurobehavioral disturbances induced by purine recycling deficiency in Drosophila

eLife
Adenine phosphoribosyltransferase (APRT) and hypoxanthine-guanine phosphoribosyltransferase (HGPRT) are two structurally related enzymes involved in purine recycling in humans.
Céline Petitgas, Laurent Seugnet, Amina Dulac, Giorgio Matassi, Ali Mteyrek, Rebecca Fima, Marion Strehaiano, Joana Dagorret, Baya Chérif-Zahar, Sandrine Marie, Irène Ceballos-Picot, Serge Birman   +11 more
doaj   +1 more source

Analyzing Pathophysiology and Immune Cells and Their Cytokines and Mediators in Precision‐Cut Slices of the Murine Lung

Current Protocols, Volume 5, Issue 1, January 2025.
Abstract Understanding the dynamic pathophysiology of diseases in the lung, such as asthma and chronic asthma, chronic obstructive pulmonary disease, and lung cancer, is crucial for the treatment, analysis, and outcome of these diseases. Unlike other traditional models, we suggest a protocol that is sustainable and reproducible and offers different ...
Michaela Tatcheff, Christine Carvalho, Jonas Willar, Elvedina Nendel, Susanne Krammer, Mircea T. Chiriac, Shuting Zhou, Carol I. Geppert, Susetta Finotto   +8 more
wiley   +1 more source

Enzyme Analysis of Oxidatively Modified Proteins Post-TBI [PDF]

, 2016
The brain is one of the most important organs in the body. It functions as a control center by regulating and coordinating actions and reactions, which is facilitated via signal transduction pathways.
Rice, Brittany
core   +1 more source

MUTATION SYSTEMS IN CULTURED MAMMALIAN CELLS * [PDF]

, 1983
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73274/1/j.1749-6632.1983.tb47827.x ...
Chu, Ernest H. Y.
core   +1 more source

Subunit Molecular Weight of Human Hypoxanthine-Guanine Phosphoribosyltransferase

Journal of Biological Chemistry, 1974
Abstract The subunit molecular weight of hypoxanthine-guanine phosphoribosyltransferase is reported to be 25,000 for the Chinese hamster enzyme (Olsen, A. S., and Milman, G. (1974) J. Biol. Chem. 249, 4030) and 34,500 for the human enzyme (Arnold, W. J., and Kelley, W. N. (1971) J. Biol. Chem. 246, 7398–7404).
Anne S. Olsen, Gregory Milman
openaire   +3 more sources

Citronellol Induces Apoptosis via Differential Regulation of Caspase‐3, NF‐κB, and JAK2 Signaling Pathways in Glioblastoma Cell Line

Food Science &Nutrition, Volume 13, Issue 1, January 2025.
Citronellol has emerged as a promising anticancer agent against glioblastoma (GBM). Network pharmacology analysis and experimentation on glioblastoma cell line have confirmed the beneficial effects of citronellol in GBM. ABSTRACT Citronellol (CT) is a naturally occurring lipophilic monoterpenoid which has shown anticancer effects in numerous cancerous ...
Muhammad Nasir Hayat Malik, Sufyan Ali, Amir Ali, Abdullah R. Alanzi, Muhammad Atif, Hattan A. Alharbi, Bowen Wang, Moosa Raza, Tahir Maqbool, Irfan Anjum, Shah Jahan, Saud O. Alshammari, Gideon F. B. Solre   +12 more
wiley   +1 more source

Description of the Lesch‐Nyhan neurobehavioral disorder and its management through participant observation of three young individuals

JIMD Reports, 2020
Background Lesch‐Nyhan disease (LND; OMIM 300322), caused by virtually absent hypoxanthine‐guanine phosphoribosyltransferase activity, in its classic form is characterised by hyperuricemia, variable cognitive impairment, severe motor disorder and a ...
Anna Bozano, Alessandra Schiaffino, Alessandra Spessa, Francesca Valeriani, Raimondo Mancinelli, Vanna Micheli, Diego Dolcetta   +6 more
doaj   +1 more source

Hypoxanthine-guanine phosphoribosyltransferase deficiency: activity in normal, mutant, and heterozygote-cultured human skin fibroblasts.

Proceedings of the National Academy of Sciences of the United States of America, 1970
Cultured skin fibroblasts from patients deficient for the enzyme hypoxanthine-guanine phosphoribosyltransferase (PRT) activity show very low but nevertheless significant levels of apparent PRT enzyme despite absence of detectable activity (
Fujimoto Wy, Seegmiller Je
semanticscholar   +1 more source

A Rapid and Specific Method for Separation of Bound and Free Antigen in Radioimmunoassay Systems [PDF]

, 1979
Peer ...
Müller, O. A., Scriba, Peter Christian, Stalla, G., Wood, W. G.   +3 more
core   +2 more sources