5'-nucleotidases, nucleosides and their distribution in the brain: pathological and therapeutic implications [PDF]
, 2013 Elements of the nucleoside system (nucleoside levels, 5'-nucleotidases (5'NTs) and other nucleoside metabolic enzymes, nucleoside transporters and nucleoside receptors) are unevenly distributed in the brain, suggesting that nucleosides have region ...
Dobolyi, Árpád +3 more
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Emerging Role of Purine Metabolizing Enzymes in Brain Function and Tumors [PDF]
, 2018 The growing evidence of the involvement of purine compounds in signaling, of nucleotide imbalance in tumorigenesis, the discovery of purinosome and its regulation, cast new light on purine metabolism, indicating that well known biochemical pathways may ...
Allegrini, Simone +5 more
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Proceedings of the National Academy of Sciences of the United States of America, 1975 We have transferred the human gene for hypoxanthine-guanine phosphoribosyltransferase (HPRT, EC 2.4.2.8; IMP:pyrophosphate phosphoribosyltransferease) via isolated metaphase chromosomes from human HeLa S3 cells into murine A9 cells which lack functional ...
K. Willecke, F. Ruddle
semanticscholar +1 more source
Molecular characterization of hypoxanthine guanine phosphoribosyltransferase mutant T cells in human blood: The concept of surrogate selection for immunologically relevant cells. [PDF]
Mutat Res Rev Mutat Res, 2022 Kaitz NA +5 more
europepmc +1 more source
Immunization with purine salvation pathway recombinant enzymes induces the production of anti- Schistosoma mansoni immunoglobulines [PDF]
Schistosomiasis, a disease caused by the trematodes of the Schistosoma genus, affects about 240 million people worldwide. The Praziquantel (PZQ) is the drug used to treat this disease. However, reports of resistant strains reinforce the need to develop a
Adachi, Felipe de Pontes +10 more
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Isolation of Nucleoside Metabolizing Enzymes from Alaska Pea Seeds (Pisum sativum L. cultivar Alaska) [PDF]
, 2013 The activities of number of metabolizing enzymes were determined from dry Alaska Pea Seeds (Pisum sativum L. cultivar Alaska). Then tested for presence of three groups of enzymes; nucleosidase, deaminases and phosphorylases. The highest activity of the
Altawil, Zahrah Mohammad
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Hypoxanthine-guanine phosphoribosyltransferase variant associated with accelerated purine synthesis.
Journal of Clinical Investigation, 1973 We have previously described a 14-yr-old boy with hyperuricemia, renal failure, and accelerated purine production resistant in vivo and in vitro to purine analogs.
P. Benke, N. Herrick, A. Hebert
semanticscholar +1 more source
CHARACTERIZATION OF ADENOSINE NUCLEOSIDASE FROM SOYBEAN SEEDS (Glycine max L.) [PDF]
, 2013 The nucleoside salvage pathway plays a key role in the growth and development of plants. The activities of several enzymes of the nucleoside salvage pathway were determined in germinated soybean seeds.
JarAllah, Lola
core +1 more source
Overproduction of Uric Acid in Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency [PDF]
, 1979 N. Lawrence Edwards +2 more
openalex +1 more source
Structural and functional studies of enzymes in nucleotide metabolism [PDF]
, 2011 Enzymes in nucleotide metabolism serve as the producers of the building blocks for DNA and RNA. From a medical perspective, nucleotide metabolism, and in particular salvage pathway enzymes, have attracted special interest, as nucleoside prodrugs given in
Egeblad, Louise
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