Gene Expression Analysis of HPRT-Deficient Cells Maintained with Physiological Levels of Folic Acid [PDF]
CellsLesch–Nyhan disease (LND) is associated with a complete deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT) activity due to mutations in the HPRT1 gene.
Rosa J. Torres +4 more
doaj +2 more sources
Novel hypoxanthine guanine phosphoribosyltransferase gene mutations in Saudi Arabian hyperuricemia patients. [PDF]
Biomed Res Int, 2014 Alanazi M +7 more
europepmc +3 more sources
The Effect of Two Weeks of High-intensity Interval Training on Salvage nucleotide pathway [PDF]
فیزیولوژی ورزش و فعالیت بدنی, 2022 Purpose: The effects of exercise adaptation on improving the purine nucleotides components are inevitable, and physical activity improves the purine nucleotide salvage pathway.
Abbas Ghanbari Niaki +1 more
doaj +1 more source
Context-Specific Metabolic Alterations in HPRT1 Knockout Cells Within a 3D Culture System. [PDF]
Cancer MedCancer metabolism studies in 2D culture models often overlook the in vivo complexity. We found that HPRT1 knockout suppressed cell proliferation in 3D and in vivo, but had minimal effect in 2D. Metabolomic analysis also revealed that HPRT1 knockout increased carnosine production via the β‐alanine pathway in 3D cultures. ABSTRACT Background Cancer cells
Tabata S +3 more
europepmc +2 more sources
Pathogens, 2023 Schistosomiasis is one of the most important human helminthiases worldwide. Praziquantel is the current treatment, and no vaccine is available until the present.
Ana Carolina Maragno Fattori +10 more
doaj +1 more source
Research Advances in Purine Phosphoribosyltransferases of Protozoan Parasites
Guangdong nongye kexue, 2023 Parasitic protozoa are single-celled organisms that have adapted to live in cells of humans and animals. The protozoan parasites include Leishmania spp., Trypanosoma spp., Plasmodium spp., Toxoplasma gondii, Cryptosporidium spp., and Eimeria spp., which ...
Zhihui YU +7 more
doaj +1 more source
Analysis of parameters of purine metabolism in patients with diabetes mellitus type 2
Medičnì Perspektivi, 2023 The aim of this research is to comprehensively analyze the current state of purine metabolism as well as assess its features in patients with diabetes mellitus type 2, taking into account the clinical and metabolic polymorphism of the disease.
A.O. Chernyaeva +2 more
doaj +1 more source
Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy
Hepatology, EarlyView., 2022 Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann +25 more
wiley +1 more source
Chinese Hamster Hypoxanthine-Guanine Phosphoribosyltransferase
Journal of Biological Chemistry, 1974 Anne S. Olsen, Gregory Milman
openaire +2 more sources
C1'-Branched Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium Falciparum 6-Oxopurine Phosphoribosyltransferase. [PDF]
ChemMedChemNovel C1'‐branched acyclic nucleoside phosphonates were synthesized. The compounds are inhibitors of Plasmodium falciparum and human 6‐oxopurine phosphoribosyltransferases with Ki values as low as 0.4 µM and 0.7 µM, respectively. A phosphonodiamidate prodrug exhibited IC50 = 4.3 µM against a drug‐sensitive strain of P.
Frydrych J +11 more
europepmc +2 more sources