Research Advances in Purine Phosphoribosyltransferases of Protozoan Parasites
Guangdong nongye kexue, 2023 Parasitic protozoa are single-celled organisms that have adapted to live in cells of humans and animals. The protozoan parasites include Leishmania spp., Trypanosoma spp., Plasmodium spp., Toxoplasma gondii, Cryptosporidium spp., and Eimeria spp., which ...
Zhihui YU +7 more
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Analysis of parameters of purine metabolism in patients with diabetes mellitus type 2
Medičnì Perspektivi, 2023 The aim of this research is to comprehensively analyze the current state of purine metabolism as well as assess its features in patients with diabetes mellitus type 2, taking into account the clinical and metabolic polymorphism of the disease.
A.O. Chernyaeva +2 more
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Clinical Images: Osteomyelitis complicating uncommon tophaceous gout: a case study with genetic findings. [PDF]
ACR Open RheumatolACR Open Rheumatology, Volume 7, Issue 1, January 2025.
Colina M, Salomoni MG, Poerio A.
europepmc +2 more sources
ACS Chemical Biology, 2022 Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT) is essential for purine salvage of hypoxanthine into parasite purine nucleotides.
Yacoba V T Minnow +9 more
semanticscholar +1 more source
Severe myelosuppression and alopecia after thiopurine initiation in a patient with NUDT15 deficiency. [PDF]
Br J Clin PharmacolThiopurines are a class of immunosuppressant and antineoplastic agents. They are widely used in the treatment of inflammatory bowel disease, haematological malignancies and autoimmune diseases, but can cause significant toxicity. Inherited gene mutations are now recognized as independent risk factors for severe adverse drug reactions to thiopurines ...
Wu AS, Mozessohn L, Kim RB, Zipursky JS.
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Identification of a new lesch-nyhan syndrome mutation (HPRT BRASIL) and analysis of potentially heterozygous females [PDF]
Arquivos de Neuro-Psiquiatria, 1999 The mutation in the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene has been determined in two brothers affected with Lesch-Nyhan syndrome. Female members of the family who are at risk for being heterozygous carriers of the HPRT mutation were ...
PATRICK O'NEILL +10 more
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Association between Cigarette Smoking and Hypoxanthine Guanine Phosphoribosyltransferase Activity
Kaohsiung Journal of Medical Sciences, 2005 The aim of this study was to investigate the association between smoking behavior and hypoxanthine guanine phosphoribosyltransferase (HGPRT) activity. A cross-sectional study was performed of 82 men, including 38 non-smokers and 44 smokers.
Shun-Jen Chang +4 more
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Human hypoxanthine-guanine phosphoribosyltransferase.
Journal of Biological Chemistry, 1983 A mutant form of human hypoxanthine-guanine phosphoribosyltransferase (HPRTToronto) was isolated from erythrocytes of a male patient with gout due to a partial deficiency of enzyme activity. The tryptic peptides of HPRTToronto were mapped by reverse-phase high pressure liquid chromatography in an attempt to define the precise abnormality in its primary
James M. Wilson +3 more
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Metabolic engineering of the purine biosynthetic pathway in Corynebacterium glutamicum results in increased intracellular pool sizes of IMP and hypoxanthine [PDF]
, 2012 Background: Purine nucleotides exhibit various functions in cellular metabolism. Besides serving as building blocks for nucleic acid synthesis, they participate in signaling pathways and energy metabolism.
Barduhn, Tobias +5 more
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HPRTSardinia: a new point mutation causing HPRT deficiency without Lesch–Nyhan disease [PDF]
, 2006 Hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency always causing hyperuricemia presents various degrees of neurological manifestations, the most severe which is Lesch–Nyhan syndrome.
Carcassi, Aldo +9 more
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