The Journal of Physiology, EarlyView.Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma +12 more
wiley +1 more source
Selective degradation of abnormal proteins in mammalian tissue culture cells. [PDF]
, 1974 Journal ArticleThe degradation rates of several missense mutants of hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) in mouse L cells are compared to those of the wild-type enzyme.
Capecchi, Mario R. +1 more
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Food Science &Nutrition, Volume 13, Issue 6, June 2025.This study demonstrates that the aqueous extract of Baccaurea ramiflora leaves (BrLAE) possesses significant antioxidant and anti‐inflammatory properties. BrLAE treatment effectively reduced CFA‐induced paw edema, improved hematological and biochemical parameters, and downregulated pro‐inflammatory gene expression in Wistar rats.
Muhammad Nasir Hayat Malik +11 more
wiley +1 more source
Hepatitis B virus infection and replication in a new cell culture system established by fusing HepG2 cells with primary human hepatocytes [PDF]
, 2016 BackgroundHepatitis B virus (HBV) infection is strictly species and tissue specific, therefore none of the cell models established previously can reproduce the natural infection process of HBV in vitro.
Guan, Yan-Yan +5 more
core +1 more source
The Role of Metabolic Testing in the Diagnostic Evaluation of Adult NORSE: A Retrospective, Single‐Centre Study [PDF]
Eur J NeurolABSTRACT Background New‐onset refractory status epilepticus (NORSE) is a diagnostically challenging and severe epileptic presentation in which aetiology is an important predictor of outcome. This retrospective study aimed to investigate the utility of metabolic screening to determine the underlying cause in 42 patients with suspected NORSE, admitted to
Kilmer J +6 more
europepmc +2 more sources
Biochemical Profiling of Gout Patients [PDF]
, 2006 The purpose of the research is to investigate the biochemical cause of gout in 82 patients. The gouty patients had been diagnosed with gout according to the criterion of the American Rheumatism Association.
Schlitt, Tamera Fayre
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Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammation [PDF]
, 2016 Objective: Transient receptor potential canonical 5 (TRPC5) is functionally expressed on a range of cells including fibroblast-like synoviocytes, which play an important role in arthritis. A role for TRPC5 in inflammation has not been previously shown in
Aisah A Aubdool +52 more
core +3 more sources
Harnessing nucleotide metabolism and immunity in cancer: a tumour microenvironment perspective
The FEBS Journal, Volume 292, Issue 9, Page 2155-2172, May 2025.This review explores how changes in nucleotide metabolism affect the tumour microenvironment and immune responses in cancer. Here, we discuss the dual role of nucleotide metabolism in promoting cancer cell growth and shaping immune suppression. We highlight how therapies targeting nucleotide pathways can enhance immunotherapy efficacy, offering new ...
Hadil Suleiman +5 more
wiley +1 more source
Nucleosided derived antibiotics to fight microbial drug resistance: New utilities for an established class of drugs? [PDF]
, 2016 Novel antibiotics are urgently needed to combat the rise of infections due to drug-resistant microorganisms. Numerous natural nucleosides and their synthetically modified analogues have been reported to have moderate to good antibiotic activity against ...
Ferrari, Valentina +2 more
core +1 more source
Molecular characterization of Borrelia persica, the agent of tick borne relapsing fever in Israel and the Palestinian Authority. [PDF]
PLoS ONE, 2010 The identification of the Tick Borne Relapsing Fever (TBRF) agent in Israel and the Palestinian Authority relies on the morphology and the association of Borrelia persica with its vector Ornithodoros tholozani. Molecular based data on B. persica are very
Gracia Safdie +13 more
doaj +1 more source