Results 81 to 90 of about 14,819 (239)

Molecular characterization of Borrelia persica, the agent of tick borne relapsing fever in Israel and the Palestinian Authority. [PDF]

PLoS ONE, 2010
The identification of the Tick Borne Relapsing Fever (TBRF) agent in Israel and the Palestinian Authority relies on the morphology and the association of Borrelia persica with its vector Ornithodoros tholozani. Molecular based data on B. persica are very
Gracia Safdie, Iba Y Farrah, Reem Yahia, Esther Marva, Amos Wilamowski, Samer S Sawalha, Naama Wald, Judith Schmiedel, Annette Moter, Ulf B Göbel, Herve Bercovier, Ziad Abdeen, Marc V Assous, Yolanta Fishman   +13 more
doaj   +1 more source

Subunit Molecular Weight of Human Hypoxanthine-Guanine Phosphoribosyltransferase

Journal of Biological Chemistry, 1974
Abstract The subunit molecular weight of hypoxanthine-guanine phosphoribosyltransferase is reported to be 25,000 for the Chinese hamster enzyme (Olsen, A. S., and Milman, G. (1974) J. Biol. Chem. 249, 4030) and 34,500 for the human enzyme (Arnold, W. J., and Kelley, W. N. (1971) J. Biol. Chem. 246, 7398–7404).
A S, Olsen, G, Milman
openaire   +2 more sources

Glucose-Dependent Insulinotropic Polypeptide (GIP) Induces Calcitonin Gene-Related Peptide (CGRP)-I and Procalcitonin (Pro-CT) Production in Human Adipocytes [PDF]

, 2011
Context: Increased plasma levels of glucose-dependent insulinotropic polypeptide (GIP), calcitonin CT gene-related peptide (CGRP)-I, and procalcitonin (Pro-CT) are associated with obesity.
Christ-Crain, Mirjam, Dembinski, Kaethi, Frey, Daniel M., Grisouard, Jean, Häring, Andreas, Keller, Ulrich, Müller, Beat, Peterli, Ralph, Radimerski, Tanja, Timper, Katharina, Zulewski, Henryk   +10 more
core   +1 more source

Xanthine calculi in a patient with Lesch-Nyhan syndrome and factor V Leiden treated with allopurinol: case report

BMC Pediatrics, 2018
Background Lesch-Nyhan syndrome is a rare inborn error of purine metabolism marked by a complete deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT).
Lisa B. E. Shields, Dennis S. Peppas, Eran Rosenberg   +2 more
doaj   +1 more source

Xanthine oxidase activity in thiopurine curative Chinese inflammatory bowel disease patients

Pharmacology Research & Perspectives, 2021
Xanthine oxidase (XO) competes with thiopurine S‐methyltransferase (TPMT) and hypoxanthine guanine phosphoribosyltransferase (HPRT) to metabolize azathioprine (AZA)/6‐mercaptopurine (6‐MP) in vivo.
Liang Ding, Fang‐bin Zhang, Hui Liu, Xiang Gao, Hui‐chang Bi, Ling Huang, Xue‐ding Wang, Bai‐li Chen, Yu Zhang, Chuanzhu Lv, Pin‐jin Hu, Min Huang   +11 more
doaj   +1 more source

The fate of thiopurine metabolites after switching to low‐dose thiopurine with allopurinol or thioguanine in IBD patients: A retrospective analysis

British Journal of Clinical Pharmacology, Volume 91, Issue 10, Page 2865-2873, October 2025.
Aims Shunting (hypermethylating) thiopurine metabolism, characterized by excessive 6‐MMPR production and (sub)therapeutic 6‐TGN levels, poses a significant challenge in the treatment of inflammatory bowel disease (IBD). This study evaluates the metabolic outcomes of switching to low‐dose thiopurine with allopurinol (LDTA) or thioguanine (TG) in IBD ...
Ahmed B. Bayoumy, Hedwig M. A. D'Agnolo, Nanne K. H. de Boer, Chris J. J. Mulder, Luc J. J. Derijks   +4 more
wiley   +1 more source

Purine salvage promotes treatment resistance in H3K27M-mutant diffuse midline glioma

Cancer & Metabolism
Background Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPGs), are a fatal form of brain cancer. These tumors often carry a driver mutation on histone H3 converting lysine 27 to methionine (H3K27M).
Erik R. Peterson, Peter Sajjakulnukit, Andrew J. Scott, Caleb Heaslip, Anthony Andren, Kari Wilder-Romans, Weihua Zhou, Sravya Palavalasa, Navyateja Korimerla, Angelica Lin, Alexandra O’Brien, Ayesha Kothari, Zitong Zhao, Li Zhang, Meredith A. Morgan, Sriram Venneti, Carl Koschmann, Nada Jabado, Costas A. Lyssiotis, Maria G. Castro, Daniel R. Wahl   +20 more
doaj   +1 more source

A Golgi study of neuronal architecture in a genetic mouse model for Lesch–Nyhan disease

Neurobiology of Disease, 2005
Lesch–Nyhan disease (LND) is an inherited disorder associated with deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT), an enzyme essential for purine recycling.
Ivan Mikolaenko, Lekha M. Rao, Rosalinda C. Roberts, Bryan Kolb, H.A. Jinnah   +4 more
doaj   +1 more source

Concentration and synthesis of phosphoribosylpyrophosphate in erythrocytes from normal, hyperuricemic, and gouty subjects. [PDF]

, 1971
Phosphoribosylpyrophosphate (PRPP) synthetase activity and the intracellular concentration of PRPP were assayed in erythrocytes from patients with primary hyperuricemia and primary metabolic gout.
Meyskens, FL, Williams, HE
core  

Metabolic Reprogramming of Cancer Cells and Therapeutics Targeting Cancer Metabolism

Cancer Medicine, Volume 14, Issue 18, September 2025.
ABSTRACT Background Cancer metabolism is a field focused on the unique alterations in metabolic pathways that occur in cancer cells, distinguishing them from the metabolic processes in normal cells. Methods An extensive review of the current literature on the metabolic adaptation of cancer cells was carried out in the current study. Results The rapidly
Jilsy M. J. Punnasseril, Abdul Auwal, Vinod Gopalan, Alfred King‐Yin Lam, Farhadul Islam   +4 more
wiley   +1 more source