Results 131 to 140 of about 103,245 (286)

Elevated cortisol concentration in preterm sheep fetuses impacts heart development

open access: yesExperimental Physiology, EarlyView.
Abstract The prepartum rise in cortisol promotes cardiac development and maturation. Here, we investigated the impact of elevated circulating cortisol during mid‐late gestation on cardiac growth and metabolism in fetal sheep. Saline or cortisol (2–3 mg in 4.4 mL/24 h) was infused into the fetal jugular vein from 109 to 116 days gestation (dG, term ...
Reza Amanollahi   +9 more
wiley   +1 more source

Fetal glucose availability: a key regulator of the metabolic, hormonal and contractility profiles of the fetal sheep heart

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend To investigate the role of glucose availability in fetal left ventricle (LV) development, this study assessed whether maternal late gestation undernutrition (LGUN; 50% of Control diet) induced alterations in the contractility, metabolic, and hormonal profile can be ameliorated in LGUN fetuses receiving glucose infusion (LGUN+G ...
Melanie R. Bertossa   +10 more
wiley   +1 more source

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma   +12 more
wiley   +1 more source

Opportunities and Challenges of the Application of Nuclear Magnetic Resonance‐Based Cerebrospinal Fluid Metabolomics for Clinical Research

open access: yesChemistry–Methods, Volume 5, Issue 12, November 2025.
Cerebrospinal fluid (CSF) is an important diagnostic matrix in neurology. This review illustrates the potentials and pitfalls of current CSF analysis by nuclear magnetic resonance. Created with BioRender.com in BioRender. Berezhnoy, G. (2025) https://BioRender.com/x80l903. Web of Science is owned by Clarivate.
Georgy Berezhnoy   +4 more
wiley   +1 more source

Liupao Tea Relieves Constipation by Activating the PI3K/Akt Pathway to Down‐Regulate AQP3 and Restore Gut Microbiota

open access: yesFood Science &Nutrition, Volume 13, Issue 12, December 2025.
Liupao tea, a Guangxi dark tea, alleviates constipation in rats by increasing fecal water content, reducing pro‐inflammatory cytokines (TNF‐α, IL‐6, IL‐1β) in the colon and stomach tissues. Western blot analysis confirms that Liupao tea activates the PI3K/Akt pathway while suppressing AQP3 expression.
Wenxin Yu   +5 more
wiley   +1 more source

Mechanisms of base selection by the E.coli mispaired uracil glycosylase [PDF]

open access: yes, 2008
The repair of the multitude of single-base lesions formed daily in the cells of all living organisms is accomplished primarily by the base-excision repair (BER) pathway that initiates repair through a series of lesion-selective glycosylases.
Darwanto, Agus   +6 more
core   +2 more sources

Dual‐Function Plant‐Derived Nanovesicles From Regenerated Cannabis sativa Roots for Immunotherapy and Vaccine Delivery

open access: yesJournal of Extracellular Vesicles, Volume 14, Issue 12, December 2025.
Schematic diagram illustrating the immunotherapeutic and vaccine delivery potential of I‐PDNVs. ABSTRACT Cannabis sativa is a medicinal plant that produces a diverse array of pharmacologically active metabolites, making it a valuable resource for pharmaceutical applications. In this study, an adventitious root (AR) culture system was established from C.
Su Hyun Park   +11 more
wiley   +1 more source

Hypoxanthine is a checkpoint stress metabolite in colonic epithelial energy modulation and barrier function

open access: yesJournal of Biological Chemistry, 2018
Scott Lee   +6 more
semanticscholar   +1 more source

Exploring Desmin as a Potential Modifier in Duchenne Muscular Dystrophy–Associated Cardiomyopathy

open access: yesActa Physiologica, Volume 241, Issue 12, December 2025.
ABSTRACT Aim Duchenne muscular dystrophy (DMD), a rare X‐linked genetic disorder, is affecting skeletal and cardiac muscles due to the loss of the dystrophin protein. Modifier proteins, whose expression is altered in DMD patients, may influence disease progression.
Brice‐Emmanuel Guennec   +12 more
wiley   +1 more source

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