Results 131 to 140 of about 74,149 (232)

Strong, specific, monodentate G-C base pair recognition by N7-inosine derivatives in the pyrimidine•purine-pyrimidine triple-helical binding motif [PDF]

, 2017
The nucleoside analogs 7-(2′-deoxy-α-D-ribofuranosyl)hypoxanthine (β7H, 1), 7-(2′-deoxy-β-D-ribofuranosyl)hypoxanthine (β7H, 2) and 7-(2′-O-methyl-β-Dribofuranosyl)hypoxanthine (β7HOMe, 3) were prepared and incorporated into triplex forming ...
Leumann, Christian J., Marfurt, Judith, Parel, Serge P.   +2 more
core  

Elevated cortisol concentration in preterm sheep fetuses impacts heart development

Experimental Physiology, EarlyView.
Abstract The prepartum rise in cortisol promotes cardiac development and maturation. Here, we investigated the impact of elevated circulating cortisol during mid‐late gestation on cardiac growth and metabolism in fetal sheep. Saline or cortisol (2–3 mg in 4.4 mL/24 h) was infused into the fetal jugular vein from 109 to 116 days gestation (dG, term ...
Reza Amanollahi, Stacey L. Holman, Melanie R. Bertossa, Ashley S. Meakin, Vicki L. Clifton, Kent L. Thornburg, I. Caroline McMillen, Michael D. Wiese, Mitchell C. Lock, Janna L. Morrison   +9 more
wiley   +1 more source

Fetal glucose availability: a key regulator of the metabolic, hormonal and contractility profiles of the fetal sheep heart

The Journal of Physiology, EarlyView.
Abstract figure legend To investigate the role of glucose availability in fetal left ventricle (LV) development, this study assessed whether maternal late gestation undernutrition (LGUN; 50% of Control diet) induced alterations in the contractility, metabolic, and hormonal profile can be ameliorated in LGUN fetuses receiving glucose infusion (LGUN+G ...
Melanie R. Bertossa, Jack R. T. Darby, Stacey L. Holman, Steven K. S. Cho, Ashley S. Meakin, Mitchell C. Lock, Jordan A. Minns, Michael D. Wiese, Christopher K. Macgowan, Mike Seed, Janna L. Morrison   +10 more
wiley   +1 more source

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

The Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas   +12 more
wiley   +1 more source

A ratiometric fluorescent probe for hypoxanthine detection in aquatic products based on the enzyme mimics and fluorescence of cobalt-doped carbon nitride

Food Science and Human Wellness
A ratiometric fluorescent probe for hypoxanthine (Hx) detection was established based on the mimic enzyme and fluorescence characteristics of cobalt-doped graphite-phase carbon nitride (Co doped g-C3N4).
Xin Wang, Chengyi Hong, Zhengzhong Lin, Zhiyong Huang   +3 more
doaj   +1 more source

Exploring the Healing Potential of Aqueous Extract of Baccaurea ramiflora Leaves in Inflammation: A Cytokine and Prostaglandin Modulator

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
This study demonstrates that the aqueous extract of Baccaurea ramiflora leaves (BrLAE) possesses significant antioxidant and anti‐inflammatory properties. BrLAE treatment effectively reduced CFA‐induced paw edema, improved hematological and biochemical parameters, and downregulated pro‐inflammatory gene expression in Wistar rats.
Muhammad Nasir Hayat Malik, Md. Mahedi Hassan Tusher, Begum Rokeya, Sidra Javaid, Saud O. Alshammari, Amr S. Abouzied, Qamar A. Alshammari, Abdulkarim Alshammari, Maryam Zaib, Hafiz Muhammad Bilal, Muhammad Atif, Gideon F. B. Solre   +11 more
wiley   +1 more source

Serum Metabolite Profile in Progressive Versus Nonprogressive Alcohol‐Related Liver Disease: A Cross‐Sectional Metabolomics Study

Liver International, Volume 45, Issue 6, June 2025.
ABSTRACT Background and Aims Alcohol‐related liver disease (ALD) is a major cause of mortality and disability‐adjusted life years. It is not fully understood why a small proportion of patients develop progressive forms of ALD (e.g., fibrosis and cirrhosis). Differences in the metabolic processes could be behind the individual progression of ALD.
Eemeli Puhakka, Hany Ahmed, Retu Haikonen, Sophie Leclercq, Kati Hanhineva, Luca Maccioni, Camille Amadieu, Marko Lehtonen, Ville Männistö, Jaana Rysä, Peter Stärkel, Olli Kärkkäinen   +11 more
wiley   +1 more source

Arabidopsis GH3.10 conjugates jasmonates

Plant Biology, Volume 27, Issue 4, Page 476-491, June 2025.
12‐hydroxy jasmonate is directly converted into 12‐hydroxy jasmonoyl‐isoleucine and fertile jasmonoyl‐isoleucine deficient Arabidopsis mutants point towards the presence of other bioactive jasmonates in flowers. Abstract Jasmonates regulate plant development and defence. In angiosperms, the canonical bioactive jasmonate is jasmonoyl‐isoleucine (JA‐Ile),
B. Ni, M. Klein, B. Hossbach, K. Feussner, E. Hornung, C. Herrfurth, M. Hamberg, I. Feussner   +7 more
wiley   +1 more source

In Vitro Psilocybin Synthesis by Co‐Immobilized Enzymes

Chemistry – A European Journal, Volume 31, Issue 29, May 22, 2025.
The drug candidate and psychedelic mushroom product psilocybin was produced by multienzyme‐charged beads in a biocatalytic cell‐free approach. Using immobilized fungal indolethylamine biosynthetic and additional bacterial enzymes, these beads turned over 4‐hydroxy‐l‐tryptophan to psilocybin.
Tim Schäfer, Alexander Sherwood, Thomas Kirkland, Thomas Krüger, Jakob Worbs, Olaf Kniemeyer, Markus Gressler, Dirk Hoffmeister   +7 more
wiley   +1 more source

Evaluation of the Uricogenic Effect of Hypoxanthine and the Hypoxanthine‐Lowering Process of Shrimp (Metapenaeus ensis)

Food Frontiers
One of the main reasons for hyperuricemia is high purine intake and restricting the intake of high purine food is the main management for avoiding hyperuricemia.
Wanqian Sha, Lu xiao, Chunlin Tao, Chuanli Hou, Yanbo Wang, Huilin Liu, Jiaoyan Ren   +6 more
doaj   +1 more source