Results 141 to 150 of about 103,245 (286)

Hypoxanthine is a pharmacodynamic marker of ischemic brain edema modified by glibenclamide [PDF]

, 2022
Hannah Irvine, Animesh Acharjee, Zoe Wolcott, Zsuzsanna Ament, Holly E. Hinson, Bradley J. Molyneaux, J. Marc Simard, Kevin N. Sheth, W. Taylor Kimberly   +8 more
openalex   +1 more source

A Porcine Monoclonal Antibody Targeting a Conserved GP4 Epitope Protects against In Vivo Infection via the Induction of Broad‐Spectrum PRRSV Neutralization

Advanced Science, Volume 12, Issue 44, November 27, 2025.
This study developed mAb‐5F2, a monoclonal antibody targeting conserved GP4 residues (Q48/I50), which blocks the GP4‐CD163 interaction, resulting in a 78–85% reduction in viral entry. Porcineized 5F2‐pFc prevented mortality in infected piglets, reduced pulmonary viral loads, and minimized lesions. This broad‐spectrum antibody platform overcomes vaccine
Xu Chen, Jiakai Zhao, Pinpin Ji, Xiaoxuan Li, Hui Niu, Dian Jiao, Lu Zhang, Qianyi Zhu, Xinyu Liu, Julian A. Hiscox, James P. Stewart, Yani Sun, Qin Zhao   +12 more
wiley   +1 more source

Effects of industrial heat treatments on the kinetics of inactivation of antimicrobial bovine milk xanthine oxidase. [PDF]

, 2019
Milk is a source of antimicrobial systems such as xanthine oxidoreductase, which has been proposed to modulate the oral and gut microbiota of infants.
de Moura Bell, Juliana MLN, German, J Bruce, Ozturk, Gulustan   +2 more
core  

Xanthine Accumulation during Hypoxanthine Oxidation by Milk Xanthine Oxidase [PDF]

, 1973
Maria Jeżewska
openalex   +1 more source

Inhibition and Mechanism of Plasmodium falciparum Hypoxanthine–Guanine–Xanthine Phosphoribosyltransferase

, 2022
Yacoba V. T. Minnow, Kajitha Suthagar, Keith Clinch, Rodrigo G. Ducati, Agnidipta Ghosh, Joshua N. Buckler, Rajesh K. Harijan, Sean M. Cahill, Peter C. Tyler, Vern L. Schramm   +9 more
openalex   +2 more sources

Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas [PDF]

, 2023
Jianxing Yin, Xiefeng Wang, Xin Ge, Fangshu Ding, Zhumei Shi, Zehe Ge, Guangcun Huang, Ningwei Zhao, Dongyin Chen, Junxia Zhang, Sameer Agnihotri, Yuandong Cao, Jing Ji, Fan Lin, Qianghu Wang, Qi‐Gang Zhou, Xiuxing Wang, Yongping You, Zhimin Lu, Xu Qian   +19 more
openalex   +1 more source

Endogenous Retrovirus‐Like Particle‐Deficient CHO Cells Can be Generated by CRISPR or shRNA and Enriched Based on Cell‐Surface Expression of Retroviral Envelope Protein

Biotechnology and Bioengineering, Volume 122, Issue 11, Page 3192-3204, November 2025.
ABSTRACT Despite evidence that they are not functional or infective, retrovirus‐like particles (RVLPs), originating from endogenous proviral sequences in Chinese hamster ovary (CHO) cells, present a safety risk for biotherapeutics manufactured using this cell line due to their resemblance to other mammalian leukemia viruses.
Matthew Stuible, Sergio P. Alpuche‐Lazcano, Christian Gervais, Manon Ouimet, Julie Lippens, Martine Pagé, Audrey Morasse, Anna N. Moraitis, Yves Durocher   +8 more
wiley   +1 more source

Substrate inhibition in a human variant of hypoxanthine-guanine phosphoribosyltransferase.

, 1984
Lafras M. Steyn, Eric H. Harley
openalex   +1 more source

Influence of DNA structure on hypoxanthine and 1,N6-ethenoadenine removal by murine 3-methyladenine DNA glycosylase [PDF]

, 2000
Michael D. Wyatt
openalex   +1 more source

Metabolite‐Guided Acetylation Therapy: Astragaloside IV Reverses Diabetic Nephropathy via Gna13‐Driven Purine Metabolic Reprogramming

Food Frontiers, Volume 6, Issue 6, Page 2961-2974, November 2025.
This study unveils how ASIV reverses diabetic nephropathy by restoring Gna13‐K363 acetylation and reprogramming purine metabolism. Using spatial metabolomics and acetylproteomics, we identified zonation‐specific purine dysregulation in diabetic kidneys, with ASIV normalizing metabolite distribution (hypoxanthine, cAMP, guanine) and targeting Gna13 ...
Shi Qiu, Sifan Guo, Dandan Xie, Zhibo Wang, Ying Cai, Xian Wang, Qiang Yang, Chunsheng Lin, Hong Yao, Qiqi Zhao, Yu Guan, Songqi Tang, Yiqiang Xie, Aihua Zhang   +13 more
wiley   +1 more source