Results 91 to 100 of about 51,129 (240)

Differential impact of drugs on the outcome of ETV6-RUNX1 positive childhood B-cell precursor acute lymphoblastic leukaemia : results of the EORTC CLG 58881 and 58951 trials [PDF]

, 2018
info:eu-repo/semantics ...
Benoit, Yves, Bertrand, Y, Cave, H, Chantrain, C, Clappier, E, Costa, V, Dastugue, N, Dresse, M-F, Drunat, S, Ferster, A, Freycon, C, Gilotay, C, Girard, S, Grardel, N, Lutz, P, Mazingue, F, Millot, F, Minckes, O, Norga, K, Piette, C, Plat, G, Pluchart, C, Poiree, M, Rohrlich, P-S, Simon, P, Sirvent, N, Suciu, S, Uyttebroeck, A, van der Werff ten Bosch, J, Van Roy, Nadine, Yakouben, K   +30 more
core   +2 more sources

Pleural Effusion Formation Linked to Altered Transporter Expression Involved in Alveolar Fluid Clearance: Insights From the Monocrotaline Model of Pulmonary Hypertension

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 4, October 2025.
ABSTRACT Pleural effusions (PLEF) in pulmonary arterial hypertension (PAH), particularly in patients with isolated right heart failure, are associated with poor prognosis and increased mortality. This study investigates changes in alveolar fluid clearance (AFC) transporter expression in relation to lung fluid accumulation and PLEF formation during PAH ...
Katarina Lelkova, Katarina Hadova, Michaela Katanova, Jana Babiakova, Zuzana Albert Kmecova, Emil Babiak, Pavel Babal, Gabriel Doka, Jan Klimas, Peter Krenek   +9 more
wiley   +1 more source

Ermittlung der m-RNA-Expressionsmuster der c-jun, c-fos und c-myc Proto-Onkogene nach ex vivo Ballondilatation von Schweinekarotiden mittels semiquantitativer RT-PCR. [PDF]

, 2005
Ziel der Arbeit war die Ermittlung der mRNA Muster dreier Proto-Onkogene nach Ballondilatation in einem serumfreien Modell mit Hilfe einer zu etablierenden semiquantitativen RT PCR ohne die Verwendung radioaktiver oder fluoreszierender Substanzen ...
Alfke, Heiko (Dr.), Steinhagen, Sandra
core   +1 more source

Cardioprotective effects of the extracellular chaperone clusterin in acute myocardial infarction

European Journal of Clinical Investigation, Volume 55, Issue 10, October 2025.
In vivo, CLU−/− mice were more susceptible to acute myocardial infarction than CLU+/+ mice. Moreover, inflammation and histone levels were significantly increased in CLU−/− mice compared to CLU+/+ mice following ischemia/reperfusion. In vitro, CLU protects cardiomyocytes from histone‐ and/or hypoxia‐induced cell death.
Louwana Allawa, Antoine Poirier, Pascale Pignon, Justine Beaumont, Lucie Lebeau, Agnès Barbelivien, Thomas Bochaton, Céline Beauvillain, Daniel Henrion, Yves Delneste, Pascale Jeannin, Fabrice Prunier, Sophie Tamareille   +12 more
wiley   +1 more source

Metformin and insulin exacerbate one‐carbon metabolism deficits in pregnant growth restricted rats and impacts the placenta, fetal liver and pancreas

The Journal of Physiology, Volume 603, Issue 19, Page 5751-5775, October 1, 2025.
Abstract figure legend Uteroplacental insufficiency (growth restricted) or sham (Control) surgery was performed on embryonic day (E)18 in Wistar–Kyoto rats. Female F1 offspring were mated and restricted dams received daily metformin, insulin or vehicle from E13.
Dayna A. Zimmerman, Jessica F. Briffa, Dewei Kong, Sogand Gravina, Dara Daygon, Vinod Kumar, Karen M. Moritz, Lillian Y. Lim, Adrian K. K. Teo, Shiao‐Yng Chan, Mary E. Wlodek, James S. M. Cuffe   +11 more
wiley   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, Volume 19, Issue 9, Page 2515-2536, September 2025.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Metabolomic profiling of the synergistic effects of melittin in combination with cisplatin on ovarian cancer cells [PDF]

, 2017
Melittin, the main peptide present in bee venom, has been proposed as having potential for anticancer therapy; the addition of melittin to cisplatin, a first line treatment for ovarian cancer, may increase the therapeutic response in cancer treatment via
Alonezi, Sanad, Clements, Carol J., Dufton, Mark J., Ferro, Valerie A., Jeon, Jong-Woon, Park, Jin-Kyu, Parkinson, John A., Tusiimire, Jonans, Wallace, Jennifer, Watson, David G., Young, Louise C.   +10 more
core   +1 more source

Metabolic and neurobehavioral disturbances induced by purine recycling deficiency in Drosophila

eLife
Adenine phosphoribosyltransferase (APRT) and hypoxanthine-guanine phosphoribosyltransferase (HGPRT) are two structurally related enzymes involved in purine recycling in humans.
Céline Petitgas, Laurent Seugnet, Amina Dulac, Giorgio Matassi, Ali Mteyrek, Rebecca Fima, Marion Strehaiano, Joana Dagorret, Baya Chérif-Zahar, Sandrine Marie, Irène Ceballos-Picot, Serge Birman   +11 more
doaj   +1 more source

Immunization with purine salvation pathway recombinant enzymes induces the production of anti- Schistosoma mansoni immunoglobulines [PDF]

Schistosomiasis, a disease caused by the trematodes of the Schistosoma genus, affects about 240 million people worldwide. The Praziquantel (PZQ) is the drug used to treat this disease. However, reports of resistant strains reinforce the need to develop a
Adachi, Felipe de Pontes, Anibal, Fernanda de Freitas, Correia, Ricardo de Oliveira, Dejani, Naiara Naiana, Garratt, Richard Charles, Neris, Débora Meira, Oliveira, Sandra Regina Pereira de, Pereira, Humberto D'Muniz, Rodolpho, Joice Margareth de Almeida, Rodrigues, Vanderlei, Souza, Laís Cristina de   +10 more
core  

Pharmacology and clinical drug candidates in redox medicine [PDF]

, 2015
SIGNIFICANCE Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant ...
Casas, Ana I, Cuadrado, Antonio, Dao, V Thao-Vi, Di Lisa, Fabio, Ghezzi, Pietro, Jaquet, Vincent, Kaludercic, Nina, Maghzal, Ghassan J, Robledinos-Anton, Natalia, Schmidt, Harald H H W, Seredenina, Tamara, Stocker, Roland   +11 more
core   +2 more sources