Results 71 to 80 of about 24,062 (183)

Perfecting a high hypoxanthine phosphoribosyltransferase activity-uricase KO mice to test the effects of purine- and non-purine-type xanthine dehydrogenase (XDH) inhibitors. [PDF]

Br J Pharmacol, 2020
Hosoya T, Uchida S, Shibata S, Tomioka NH, Hosoyamada M.   +4 more
europepmc   +1 more source

Interference of Sulphonate Buffering Agents with E. coli Hypoxanthine-Guanine Phosphoribosyltransferase Active Site Functioning: A Crystallographic and Enzymological Study

Crystals
The investigation of the structure–function relationship in hypoxanthine-guanine phosphoribosyltransferases (HGPRT) is a direction that is relevant for the development of drugs and approaches of enzymatic synthesis of modified nucleosides and nucleotides.
Evgeniy A. Zayats, Yulia A. Abramchik, Maria A. Kostromina, Vladimir I. Timofeev, Mikhail B. Shevtsov, Alexey V. Mishin, Ilya V. Fateev, Andrey A. Karanov, Alexandra R. Sharafutdinova, Aleksandra O. Arnautova, Irina D. Konstantinova, Valentin I. Borshchevskiy, Roman S. Esipov   +12 more
doaj   +1 more source

Whole Exome Sequencing Facilitates Early Diagnosis of Lesch–Nyhan Syndrome: A Case Series

Diagnostics
Background: Lesch–Nyhan syndrome (LNS) is a rare X-linked recessive metabolic disorder caused by mutations in the HPRT1 gene, resulting in hypoxanthine–guanine phosphoribosyltransferase (HPRT) deficiency.
Hung-Hsiang Fang, Chung-Lin Lee, Hui-Ju Chen, Chih-Kuang Chuang, Huei-Ching Chiu, Ya-Hui Chang, Yuan-Rong Tu, Yun-Ting Lo, Hsiang-Yu Lin, Shuan-Pei Lin   +9 more
doaj   +1 more source

Human Hypoxanthine Phosphoribosyltransferase

Journal of Biological Chemistry, 1969
T A Krenitsky, R Papaioannou, G B Elion
openaire   +2 more sources

Resensitizing β‐Lactams by Reprogramming Purine Metabolism in Small Colony Variant for Osteomyelitis Treatment

Advanced Science
Small colony variant (SCV) is strongly linked to antibiotic resistance and the persistence of osteomyelitis. However, the intrinsic phenotypic instability of SCV has hindered a thorough investigation of its pathogenic mechanisms.
Tingwang Shi, Qiong Wu, Zesong Ruan, Zhiyuan Luo, Wenbo Wang, Zhao Guo, Yihong Ma, Xin Wang, Guangyu Chu, Han Lin, Min Ge, Yunfeng Chen   +11 more
doaj   +1 more source

Identifying the best reference gene for RT-qPCR analyses of the three-dimensional osteogenic differentiation of human induced pluripotent stem cells

Bone Reports
Reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) is an essential tool for gene expression analysis; choosing appropriate reference genes for normalization is crucial to ensure data reliability.
Masakazu Okamoto, Yusuke Inagaki, Kensuke Okamura, Yoshinobu Uchihara, Kenichiro Saito, Akihito Kawai, Munehiro Ogawa, Akira Kido, Eiichiro Mori, Yasuhito Tanaka   +9 more
doaj   +1 more source

Generation of hypoxanthine phosphoribosyltransferase gene knockout rabbits by homologous recombination and gene trapping through somatic cell nuclear transfer. [PDF]

Sci Rep, 2015
Yin M, Jiang W, Fang Z, Kong P, Xing F, Li Y, Chen X, Li S.   +7 more
europepmc   +1 more source

Hypoxanthine-Guanine Phosphoribosyltransferase [PDF]

, 2020
openaire   +1 more source

The development of hypoxanthine-guanine phosphoribosyltransferase activity in man [PDF]

Biochemical Journal, 1971
A, Adams, J M, Anderson, A D, Nicol, R A, Harkness   +3 more
openaire   +2 more sources

Prenatal non-infectious mild stressor modulates early-life lung development in a time-specific manner. [PDF]

Respir Res
Dong Y, Hadzic S, Leidner A, Marega M, Rivetti S, Ehrhardt H, Bellusci S.   +6 more
europepmc   +1 more source