Results 71 to 80 of about 34,291 (223)

Chronic Pre‐Trauma Corticosterone Attenuates Trauma Memory Formation and Alters Gene Expression in Glucocorticoid Signalling Pathways

Genes, Brain and Behavior, Volume 25, Issue 5, October 2026.
The graphical abstract outlines the experimental workflow and key findings, showing how chronic or acute corticosterone elevations alter FC‐induced molecular and behavioural changes during trauma memory formation, consolidation, and recall. Abbreviations: Cort.—Corticosterone; FC—Fear Conditioning; PRPs—Plasticity‐Related Proteins.
Gia Kutelia, Zurab Kuchukashvili, Rusiko Ansiani, Roza Bukia, Manana Chikovani, Butsiko Chkhartishvili, Nanuli Doreulee   +6 more
wiley   +1 more source

Hypoxanthine-Guanine Phosphoribosyltransferase Variant Associated with Accelerated Purine Synthesis

, 1973
We have previously described a 14-yr-old boy with hyperuricemia, renal failure, and accelerated purine production resistant in vivo and in vitro to purine analogs.
Norma Herrick, Hebert, Annette, Paul J. Benke, Benke, Paul J., Annette Hebert, Herrick, Norma   +5 more
core   +1 more source

Multi‐omics analysis of ion channels expressed by chicken embryo vestibular type I and type II hair cells

Experimental Physiology, Volume 111, Issue 10, Page 4894-4914, 1 October 2026.
Abstract Balance and gaze rely on the rapid and accurate detection and signalling of head movements by vestibular type I and type II hair cells. Signal transduction and transmission involve several types of ion channels, which are acquired progressively during hair cell differentiation and whose identity is known only in part.
Giulia Cheli, Roberta Giunta, Francesca Stella, Eleonora Guidi, Umberto Laforenza, Mariarosa Polimeni, Giancarlo Russo, Francesca Borgo, Lazarevic Dejan, Sergio Masetto   +9 more
wiley   +1 more source

Evaluation of the upregulation and surface expression of hypoxanthine guanine phosphoribosyltransferase in acute lymphoblastic leukemia and Burkitt’s B cell lymphoma

Cancer Cell International, 2020
Background The aim of this study is to determine whether Hypoxanthine Guanine Phosphoribosyltransferase (HPRT) could be used as a biomarker for the diagnosis and treatment of B cell malignancies.
Michelle H. Townsend, Zac E. Ence, Taylor P. Cox, John E. Lattin, Weston Burrup, Michael K. Boyer, Stephen R. Piccolo, Richard A. Robison, Kim L. O’Neill   +8 more
doaj   +1 more source

Hypoxanthine-guanine phosphoribosyltransferase and inosine 5’-monophosphate dehydrogenase activities in three mammalian species: aquatic (Mirounga angustirostris), semiaquatic (Lontra longicaudis annectens) and terrestrial (Sus scrofa)

Frontiers in Physiology, 2015
Aquatic and semiaquatic mammals have the capacity of breath hold (apnea) diving. Northern elephant seals (Mirounga angustirostris) have the ability to perform deep and long duration dives; during a routine dive, adults can hold their breath for 25 min ...
Myrna eBarjau Perez-Milicua, Tania eZenteno-Savin, Daniel E. Crocker, Juan Pablo Gallo   +3 more
doaj   +1 more source

Characterization of guanine and hypoxanthine phosphoribosyltransferases in Methanococcus voltae

Journal of Bacteriology, 1996
Phosphoribosyltransferase (PRTase) and nucleoside phosphorylase (NPase) activities were detected by radiometric methods in extracts of Methanococcus voltae. Guanine PRTase activity was present at 2.7 nmol min(-1) mg of protein(-1) and had an apparent Km for guanine of 0.2 mM and a pH optimum of 9. The activity was inhibited 50% by 0.3 mM GMP.
T L, Bowen, W C, Lin, W B, Whitman
openaire   +3 more sources

Converting the Guanine Phosphoribosyltransferase from Giardia lamblia to a Hypoxanthine-guanine Phosphoribosyltransferase [PDF]

Journal of Biological Chemistry, 2000
Guanine phosphoribosyltransferase from Giardia lamblia, a key enzyme in the purine salvage pathway, is a potential target for anti-giardiasis chemotherapy. Recent structural determination of GPRTase (Shi, W., Munagala, N. R., Wang, C. C., Li, C. M., Tyler, P. C., Furneaux, R. H., Grubmeyer, C., Schramm, V. L., and Almo, S. C.
N, Munagala, A E, Sarver, C C, Wang
openaire   +2 more sources

Evidence for multiple active states of plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase

, 2000
The lack of de novo purine biosynthesis in the malaria parasite Plasmodium falciparum makes the purine salvage enzyme hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT) a drug target.
Subbayya, I. N. Sujay, Balaram, Hemalatha   +1 more
core   +1 more source

Lesch-Nyhan syndrome: A case report

Journal of Indian Society of Pedodontics and Preventive Dentistry, 2008
Lesch-Nyhan syndrome, a rare inborn error of metabolism, is characterized by mental retardation and self-destructive behavior resulting in self-mutilation through biting and scratching.
Kale A, Shah K, Hallikerimath S
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, Volume 20, Issue 9, Page 2243-2261, September 2026.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source