Results 91 to 100 of about 34,291 (223)

Metabolic and neurobehavioral disturbances induced by purine recycling deficiency in Drosophila

eLife
Adenine phosphoribosyltransferase (APRT) and hypoxanthine-guanine phosphoribosyltransferase (HGPRT) are two structurally related enzymes involved in purine recycling in humans.
Céline Petitgas, Laurent Seugnet, Amina Dulac, Giorgio Matassi, Ali Mteyrek, Rebecca Fima, Marion Strehaiano, Joana Dagorret, Baya Chérif-Zahar, Sandrine Marie, Irène Ceballos-Picot, Serge Birman   +11 more
doaj   +1 more source

Metabolic constraint of human telomere length by nucleotide salvage efficiency

Nature Communications
Human telomere length is tightly regulated and associated with diseases at either extreme, but how these bounds are established remains incompletely understood.
William Mannherz, Andrew Crompton, Noah Lampl, Suneet Agarwal   +3 more
doaj   +1 more source

Forward and reverse sequences of primers used for the amplification of mouse genes.

, 2013
HPRT: hypoxanthine-guanine phosphoribosyltransferase; MnSOD: manganese-superoxide dismutase; MMP-2: matrix metalloproteinase type-2.
Céline Fassot (382454), Ahmed Habbout (382450), Julie Lorin (382452), Charles Guenancia (382451), Catherine Vergely (382455), Eve Rigal (382453), Luc Rochette (293691)   +6 more
core   +1 more source

Case report: Whole exome sequencing identifies a novel variant in the HPRT1 gene in a male with developmental delay

Frontiers in Genetics
Lesch-Nyhan syndrome (LNS, OMIM #300322) is a rare X-linked genetic disorder caused by variants in the HPRT1 gene, which codes for the Hypoxanthine-guanine phosphoribosyltransferase (HGPRT).
Haoyang Zheng, Haoyang Zheng, Haoyang Zheng, Gui Chen, Gui Chen, Gui Chen, Tingting Wang, Weisheng Cheng, Weisheng Cheng, Weisheng Cheng, Weisheng Cheng, Weisheng Cheng, Weisheng Cheng, Jing Yuan, Jing Yuan, Jing Yuan, Jing Yuan, Jing Yuan, Jing Yuan, Fang Liu, Fang Liu, Fang Liu, Yuanhong Xu, Yuanhong Xu, Yuanhong Xu   +24 more
doaj   +1 more source

Human hypoxanthine-guanine phosphoribosyltransferase. IMP-GMP exchange stoichiometry and steady state kinetics of the reaction.

, 1979
Steady state kinetics of hypoxanthine guanine phosphoribosyltransferase-catalyzed reactions are studied. The results obtained suggest that IMP, GMP, P-Rib-PP, and pyrophosphate bind to the same enzyme form, while hypoxanthine and guanine bind to a ...
GIACOMELLO, Alessandro, SALERNO, Costantino   +1 more
core  

Primer sequences for quantitative real-time RT-PCR.

, 2015
HPRT: hypoxanthine-guanine phosphoribosyltransferase.Primer sequences for quantitative real-time RT-PCR.
Chihiro Ito (816808), Chiaki Masuda (816810), Motoaki Takayanagi (816813), Kaori Okuyama-Dobashi (816809), Yuichi Ohkawara (816812), Miki Sato (210340), Isao Ohno (816814), Tomomitsu Miyasaka (477141), Tasuku Kawano (816811), Toshiaki Kikuchi (183766)   +9 more
core   +1 more source

LINF_210014900

, 2023
hypoxanthine-guanine phosphoribosyltransferase | HGPRT; Leishmania infantum (strain ...
Requena, Jose M., Requena, J (via Mendeley Data)   +1 more
core   +1 more source

Xanthine calculi in a patient with Lesch-Nyhan syndrome and factor V Leiden treated with allopurinol: case report

BMC Pediatrics, 2018
Background Lesch-Nyhan syndrome is a rare inborn error of purine metabolism marked by a complete deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT).
Lisa B. E. Shields, Dennis S. Peppas, Eran Rosenberg   +2 more
doaj   +1 more source

Hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv: Cloning, expression, and biochemical characterization

, 2009
Human tuberculosis (TB) is a major cause of morbidity and mortality worldwide, especially in poor and developing countries. Moreover, the emergence of Mycobacterium tuberculosis strains resistant to first- and second-line anti-TB drugs raises the ...
Santos, Diogenes S., Basso, Luiz A., Palma, Mario Sergio, Biazus, Gisele, Palma, Mario Sergio [UNESP], Schneider, Cristopher Z.   +5 more
core   +1 more source

Oligomeric state of hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis [PDF]

, 2017
Sedimentation equilibrium and size-exclusion chromatography experiments on Mycobacterium tuberculosis hypoxanthine-guanine phosphoribosyltransferase (MtHGPRT) have established the existence of this enzyme as a reversibly associating mixture of dimeric ...
Hockova, Dana, Winzor, Donald J., Guddat, Luke W., Keough, Dianne T., Eng, Wai Soon   +4 more
core   +1 more source