Results 91 to 100 of about 33,169 (270)

Serum levels of RBP4 and adipose tissue levels of PTP1B are increased in obese men resident in northeast Scotland without associated changes in ER stress response genes [PDF]

, 2012
Peer reviewedPublisher ...
Agouni, Abdelali, Delibegovic, Mirela, Hoggard, Nigel, Mody, Nimesh   +3 more
core   +3 more sources

Metabolic constraint of human telomere length by nucleotide salvage efficiency

Nature Communications
Human telomere length is tightly regulated and associated with diseases at either extreme, but how these bounds are established remains incompletely understood.
William Mannherz, Andrew Crompton, Noah Lampl, Suneet Agarwal   +3 more
doaj   +1 more source

The prognostic effect of PTEN expression status in colorectal cancer development and evaluation of factors affecting it: MiR-21 and promoter methylation [PDF]

, 2016
Background: PTEN is a tumor suppressor gene which is involved in cellular proliferation, differentiation, and apoptosis. Loss or down-regulation of PTEN plays an important role in human cancers development.
Azadeh, H., Farazmandfar, T., Yazdani, Y., Zekavatian, Z.   +3 more
core   +1 more source

Immunization with purine salvation pathway recombinant enzymes induces the production of anti- Schistosoma mansoni immunoglobulines [PDF]

Schistosomiasis, a disease caused by the trematodes of the Schistosoma genus, affects about 240 million people worldwide. The Praziquantel (PZQ) is the drug used to treat this disease. However, reports of resistant strains reinforce the need to develop a
Adachi, Felipe de Pontes, Anibal, Fernanda de Freitas, Correia, Ricardo de Oliveira, Dejani, Naiara Naiana, Garratt, Richard Charles, Neris, Débora Meira, Oliveira, Sandra Regina Pereira de, Pereira, Humberto D'Muniz, Rodolpho, Joice Margareth de Almeida, Rodrigues, Vanderlei, Souza, Laís Cristina de   +10 more
core  

Xanthine calculi in a patient with Lesch-Nyhan syndrome and factor V Leiden treated with allopurinol: case report

BMC Pediatrics, 2018
Background Lesch-Nyhan syndrome is a rare inborn error of purine metabolism marked by a complete deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT).
Lisa B. E. Shields, Dennis S. Peppas, Eran Rosenberg   +2 more
doaj   +1 more source

Differential impact of drugs on the outcome of ETV6-RUNX1 positive childhood B-cell precursor acute lymphoblastic leukaemia : results of the EORTC CLG 58881 and 58951 trials [PDF]

, 2018
info:eu-repo/semantics ...
Benoit, Yves, Bertrand, Y, Cave, H, Chantrain, C, Clappier, E, Costa, V, Dastugue, N, Dresse, M-F, Drunat, S, Ferster, A, Freycon, C, Gilotay, C, Girard, S, Grardel, N, Lutz, P, Mazingue, F, Millot, F, Minckes, O, Norga, K, Piette, C, Plat, G, Pluchart, C, Poiree, M, Rohrlich, P-S, Simon, P, Sirvent, N, Suciu, S, Uyttebroeck, A, van der Werff ten Bosch, J, Van Roy, Nadine, Yakouben, K   +30 more
core   +2 more sources

A Golgi study of neuronal architecture in a genetic mouse model for Lesch–Nyhan disease

Neurobiology of Disease, 2005
Lesch–Nyhan disease (LND) is an inherited disorder associated with deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT), an enzyme essential for purine recycling.
Ivan Mikolaenko, Lekha M. Rao, Rosalinda C. Roberts, Bryan Kolb, H.A. Jinnah   +4 more
doaj   +1 more source

A plant-derived glucocorticoid receptor modulator attenuates inflammation without provoking ligand-induced resistance [PDF]

, 2010
Background: Acquired resistance to glucocorticoids constitutes a major clinical challenge, often overlooked in the search for improved alternatives to classic steroids.
De Bosscher, Karolien, Dewint, Pieter, Elewaut, Dirk, Gossye, Valerie, Haegeman, Guy, Van Beneden, Katrien   +5 more
core   +2 more sources

A Rapid and Specific Method for Separation of Bound and Free Antigen in Radioimmunoassay Systems [PDF]

, 1979
Peer ...
Müller, O. A., Scriba, Peter Christian, Stalla, G., Wood, W. G.   +3 more
core   +2 more sources

Targeted Nucleotide Substitution in Mammalian Cell by Target-AID

Bio-Protocol, 2017
Programmable RNA-guided nucleases based on CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-associated protein) systems have been applied to various type of cells as powerful genome editing tools. By using activation-induced
Takayuki Arazoe, Keiji Nishida, Akihiko Kondo   +2 more
doaj   +1 more source