Results 81 to 90 of about 34,291 (223)

Lesch-Nyhan Syndrome: Evaluation of a Modified Bite Device to Prevent Bite Injuries

Applied Sciences, 2020
Lesch-Nyhan syndrome (LNS) is a serious form of hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency, a hereditary purine metabolism disorder. The prevalence reported in the literature is 1/380,000 to 235,000 births.
Gaetano Ierardo, Valeria Luzzi, Gian Luca Sfasciotti, Antonella Polimeni, Maurizio Bossù   +4 more
doaj   +1 more source

Quality Thresholds for Angiogenesis Under Acoustic Manipulation in Engineered Vascular Tissues

Advanced Science, Volume 13, Issue 52, 18 September 2026.
Defined biological and physical quality thresholds achieved through acoustic manipulation regulate cellular alignment and spatial organization, promoting self‐assembling vasculature, extracellular matrix deposition, and angiogenic responses, thereby establishing critical acoustic patterning requirements for engineered vascular tissue development in ...
Oscar O'Dwyer Lancaster‐Jones, Russell Quinn, Niloofar Khoshdel Rad, Kilian Paul, Andrea Frank, Daniela F. Duarte Campos   +5 more
wiley   +1 more source

Inhibition and Mechanism of Plasmodium falciparum Hypoxanthine–Guanine–Xanthine Phosphoribosyltransferase

Plasmodium falciparum hypoxanthine–guanine–xanthine phosphoribosyltransferase (PfHGXPRT) is essential for purine salvage of hypoxanthine into parasite purine nucleotides.
Rajesh K. Harijan (8636538), Keith Clinch (729809), Peter C. Tyler (729810), Joshua N. Buckler (4257481), Sean M. Cahill (2336179), Yacoba V. T. Minnow (14160862), Rodrigo G. Ducati (3341510), Agnidipta Ghosh (4825569), Vern L. Schramm (198355), Kajitha Suthagar (13806640)   +9 more
core   +2 more sources

Efficient gene targeting by homologous recombination in rat embryonic stem cells.

PLoS ONE, 2010
The rat is the preferred experimental animal in many biological studies. With the recent derivation of authentic rat embryonic stem (ES) cells it is now feasible to apply state-of-the art genetic engineering in this species using homologous recombination.
Stephen Meek, Mia Buehr, Linda Sutherland, Alison Thomson, John J Mullins, Andrew J Smith, Tom Burdon   +6 more
doaj   +1 more source

Effects of CYP2E1 Polymorphism and Dietary Supplementation With Jerusalem Artichoke on Skatole and Indole Levels in the Back Fat and Feces of Boars, and Liver mRNA Expression

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
This study investigated the combined effects of CYP2E1 gene polymorphism (SNP NM_214421.1: c.1423G > A) and short‐term dietary supplementation with Jerusalem artichoke (Helianthus tuberosus, 8.2% tuber meal) on skatole and indole concentrations in back fat and feces of 25 crossbreed boars, and on hepatic CYP2E1 mRNA expression. Animals were assigned to
Kateřina Zadinová, Antonín Stratil, Jaroslav Čítek, Monika Okrouhlá, Jan Calta, Ivan Bahelka, Kateřina Urbancová, Michal Šprysl, Roman Stupka   +8 more
wiley   +1 more source

Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase

, 2017
Acyclic nucleoside bisphosphonates (ANbPs) have previously been shown to be good inhibitors of human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) and Plasmodium falciparum (Pf) hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT).
Michael D. Edstein, Janeba, Zlatko, Hocková, Dana, Zlatko Janeba, Marina Chavchich, Luke W. Guddat, Martin Dračínský, Guddat, Luke W., Petr Špaček, Lieve Naesens, Edstein, Michael D., Dianne T. Keough, Dana Hocková, Špaček, Petr, Chavchich, Marina, Dračínský, Martin, Keough, Dianne T., Naesens, Lieve   +17 more
core   +1 more source

Proteomic profile of CSF obtained at the time of diagnosis determines amyotrophic lateral sclerosis progression and survival: CXCL7 levels in disease prognosis and survival

Brain Pathology, Volume 36, Issue 5, September 2026.
Untargeted multiomic profiling of cerebrospinal fluid reveals that proteomic, but not lipidomic, signatures robustly distinguish ALS patients from controls and stratify individuals by survival, highlighting marked molecular differences between short survival and long survival disease.
Sergio Roca‐Pereira, Yaiza López‐Sampere, Pol Mengod‐Soler, Mario Peña‐Fonteboa, Carla Marco, Alejandro Caravaca‐Puchades, Raúl Domínguez, Juan Francisco Vázquez‐Costa, Enrique Santamaría, Joaquín Fernández‐Irigoyen, María J. Colomina, Isabel León Moreno, Antonio Martínez Yélamos, Sergio Martínez Yélamos, Gabriel Santpere, Elia Obis, Manuel Portero‐Otín, Gerard Piñol‐Ripoll, Mónica Povedano, Pol Andrés‐Benito   +19 more
wiley   +1 more source

Erythrocyte phosphoribosylpyrophosphate concentrations in heterozygotes for hypoxanthine-guanine phosphoribosyltransferase deficiency

, 1974
Heterozygotes for the deficiency of hypoxanthine-guanine phosphoribosyltransferase (HGPRT) demonstrate either normal erythrocyte HGPRT activities in families in which the hemizygote shows the Lesch-Nyhan syndrome, or a range of erythrocyte HGPRT ...
Gordon R.B., Thompson L., Emmerson B.T.
core   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

Inhibition of Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase mRNA by antisense oligodeoxynucleotide sequence

, 1993
Comparative biochemical studies between the malaria parasite, Plasmodium falciparum, and its host have revealed differences in a number of metabolic pathways.
Dawson, P. A., Emmerson, B.T., Cochran, D. A., Gordon, R. B.   +3 more
core   +1 more source