Results 51 to 60 of about 24,062 (183)

Safety and efficacy of a feed additive consisting of nicarbazin (NICACOX®) for chickens for fattening and chickens reared for laying (Huvepharma N.V.)

EFSA Journal, Volume 24, Issue 8, August 2026.
Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of a feed additive consisting of nicarbazin (NICACOX®) as a coccidiostat for chickens for fattening and chickens reared for laying.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López‐Alonso, Francesca Marcon, Giovanna Martelli, Carlo Nebbia, Alena Pechová, Miguel Prieto‐Maradona, Katerina Theodoridou, Georges Bories, Paul Brantom, Jürgen Gropp, Guido Rychen, Luca Tosti, Ruud Woutersen, Jaume Galobart, Fabiola Pizzo, Alberto Navarro‐Villa, Maria Vittoria Vettori, José Cortiñas Abrahantes, Orsolya Holczknecht   +28 more
wiley   +1 more source

Lesch-Nyhan syndrome: A case report

Journal of Indian Society of Pedodontics and Preventive Dentistry, 2008
Lesch-Nyhan syndrome, a rare inborn error of metabolism, is characterized by mental retardation and self-destructive behavior resulting in self-mutilation through biting and scratching.
Kale A, Shah K, Hallikerimath S
doaj  

Hypoxanthine-guanine phosphoribosyltransferase and inosine 5’-monophosphate dehydrogenase activities in three mammalian species: aquatic (Mirounga angustirostris), semiaquatic (Lontra longicaudis annectens) and terrestrial (Sus scrofa)

Frontiers in Physiology, 2015
Aquatic and semiaquatic mammals have the capacity of breath hold (apnea) diving. Northern elephant seals (Mirounga angustirostris) have the ability to perform deep and long duration dives; during a routine dive, adults can hold their breath for 25 min ...
Myrna eBarjau Perez-Milicua, Tania eZenteno-Savin, Daniel E. Crocker, Juan Pablo Gallo   +3 more
doaj   +1 more source

Converting the Guanine Phosphoribosyltransferase from Giardia lamblia to a Hypoxanthine-guanine Phosphoribosyltransferase [PDF]

Journal of Biological Chemistry, 2000
Guanine phosphoribosyltransferase from Giardia lamblia, a key enzyme in the purine salvage pathway, is a potential target for anti-giardiasis chemotherapy. Recent structural determination of GPRTase (Shi, W., Munagala, N. R., Wang, C. C., Li, C. M., Tyler, P. C., Furneaux, R. H., Grubmeyer, C., Schramm, V. L., and Almo, S. C.
N, Munagala, A E, Sarver, C C, Wang
openaire   +2 more sources

Localization of Ceramide Synthase 5 in Mouse Retina

Journal of Comparative Neurology, Volume 534, Issue 7, July 2026.
CerS5 localizes to amacrine cells, horizontal cells, and retinal ganglion cells in the mouse retina. Its deficiency reduces C16‐ceramide and causes retinal thinning without functional ERG deficits, suggesting a structural role for CerS5 in retinal integrity. .
Soo‐Jin Song, Jae‐Hyun Koo, Hee‐Yeon Kim, Joo‐Won Park, Sun‐Sook Paik, In‐Beom Kim, Jung‐A. Shin   +6 more
wiley   +1 more source

Lesch-Nyhan Syndrome: Evaluation of a Modified Bite Device to Prevent Bite Injuries

Applied Sciences, 2020
Lesch-Nyhan syndrome (LNS) is a serious form of hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency, a hereditary purine metabolism disorder. The prevalence reported in the literature is 1/380,000 to 235,000 births.
Gaetano Ierardo, Valeria Luzzi, Gian Luca Sfasciotti, Antonella Polimeni, Maurizio Bossù   +4 more
doaj   +1 more source

Leucine‐Restricted Diet Attenuates Small Intestinal Tumorigenesis in ApcMin/+ Mice

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Essential amino acids have been implicated in intestinal physiology and disease, but their individual roles in intestinal tumorigenesis remain unclear. Among the amino acids examined, dietary leucine restriction uniquely suppressed small intestinal tumorigenesis in ApcMin/+ mice.
Yunlong Sui, Namiko Hoshi, Norihiro Okamoto, Yuna Ku, Makoto Ooi, Daisuke Watanabe, Haruka Miyazaki, Misaki Agawa, Hirotaka Nakamura, Jun Inoue, Hui Yang, Yuzo Kodama   +11 more
wiley   +1 more source

Scientific Report on consumer health‐based guidance values for trifluoroacetic acid

EFSA Journal, Volume 24, Issue 7, July 2026.
Abstract The European Commission asked EFSA to provide a scientific report according to Article 31 of Regulation (EC) No 178/2002, in conjunction with Regulation (EC) No 1107/2009, to revise consumer health‐based guidance values, i.e. acceptable daily intake (ADI) and acute reference dose (ARfD), for trifluoroacetic acid (TFA). EFSA launched a targeted
EFSA (European Food Safety Authority), Adeline Cavelier, Tamara Coja, Andrea Gall, Antonio Hernández‐Jerez, Christiane Vleminckx, Elodie Bergsma, Marco Binaglia, Federica Crivellente, Mathilde Colas, Anna Lanzoni, Jochem Louisse, Rafaela Rodrigues De Jesus, Annetta Grillo, Iris Mangas, Juan Manuel Parra Morte   +15 more
wiley   +1 more source

Efficient gene targeting by homologous recombination in rat embryonic stem cells.

PLoS ONE, 2010
The rat is the preferred experimental animal in many biological studies. With the recent derivation of authentic rat embryonic stem (ES) cells it is now feasible to apply state-of-the art genetic engineering in this species using homologous recombination.
Stephen Meek, Mia Buehr, Linda Sutherland, Alison Thomson, John J Mullins, Andrew J Smith, Tom Burdon   +6 more
doaj   +1 more source

Safety of a feed additive consisting of Macleaya cordata (Willd.) R. Br. extract and leaves (Sangrovit® Extra) for suckling and weaned piglets and other growing Suidae (Phytobiotics Futterzusatzstoffe GmbH)

EFSA Journal, Volume 24, Issue 7, July 2026.
Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety of a feed additive consisting of Macleaya cordata (Willd.) R. Br. extract and leaves (Sangrovit® Extra) as a zootechnical feed additive for suckling and weaned piglets and other growing Suidae.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López‐Alonso, Francesca Marcon, Giovanna Martelli, Carlo Nebbia, Alena Pechová, Miguel Prieto‐Maradona, Katerina Theodoridou, Maria de Lourdes Bastos, Emilio Benfenati, Paul Brantom, Andrew Chesson, Josef Schlatter, Johannes Westendorf, Paola Manini, Birgit Dusemund   +24 more
wiley   +1 more source