Results 51 to 60 of about 34,291 (223)

Oleanolic acid blocks the purine salvage pathway for cancer therapy by inactivating SOD1 and stimulating lysosomal proteolysis

Molecular Therapy: Oncolytics, 2021
Metabolic reprogramming is a core hallmark of cancer and is key for tumorigenesis and tumor progression. Investigation of metabolic perturbation by anti-cancer compounds would allow a thorough understanding of the underlying mechanisms of these agents ...
Dan Liu, Xing Jin, Guanzhen Yu, Mingsong Wang, Lei Liu, Wenjuan Zhang, Jia Wu, Fengying Wang, Jing Yang, Qin Luo, Lili Cai, Xi Yang, Xisong Ke, Yi Qu, Zhenye Xu, Lijun Jia, Wen-Lian Chen   +16 more
doaj   +1 more source

Sex‐ and Time‐Resolved Physiological and Gut Ecosystem Responses to a Food‐Grade Microbiome‐Targeted Intervention in Collegiate Endurance Athletes

Advanced Science, EarlyView.
In collegiate endurance athletes, a 6‐week randomized CPYE intervention yielded time‐ and sex‐dependent shifts in field‐based cardiorespiratory, metabolic, and redox indices, accompanied by changes in gut multi‐omics profiles. An exploratory extension during intensified training generates hypotheses warranting future validation.
Meng Zhang, Le Ge, Kaiyang Liu, Yanrong Liu, Guolin Zhao, Lai‐Yu Kwok, Zheng Sun, Zhihong Sun, Wenyi Zhang   +8 more
wiley   +1 more source

Hypoxanthine guanine phosphoribosyltransferase 1, a target of miR-125b-5p, promotes cell proliferation and invasion in head and neck squamous cell carcinoma

Heliyon, 2023
The mechanism of hypoxanthine-guanine phosphoribosyltransferase 1 (HPRT1) upregulation and its function in head and neck squamous cell carcinoma (HNSCC) remains obscure.
Li Yuan, Zhiqiang Xiao, Ruohuang Lu
doaj   +1 more source

Falling from grace: HPRT is not suitable as an endogenous control for cancer-related studies

Molecular & Cellular Oncology, 2019
HPRT is a housekeeping enzyme involved in recycling guanine and inosine in the purine salvage pathway. As a housekeeping gene, HPRT has been widely used as an endogenous control for molecular studies evaluating changes in gene expression.
Michelle H. Townsend, Abigail M. Felsted, Zac E. Ence, Stephen R. Piccolo, Richard A. Robison, Kim L. O’Neill   +5 more
doaj   +1 more source

Restoring Ureagenesis in Hepatocytes by CRISPR/Cas9-mediated Genomic Addition to Arginase-deficient Induced Pluripotent Stem Cells

Molecular Therapy: Nucleic Acids, 2016
Urea cycle disorders are incurable enzymopathies that affect nitrogen metabolism and typically lead to hyperammonemia. Arginase deficiency results from a mutation in Arg1, the enzyme regulating the final step of ureagenesis and typically results in ...
Patrick C Lee, Brian Truong, Agustin Vega-Crespo, W Blake Gilmore, Kip Hermann, Stephanie AK Angarita, Jonathan K Tang, Katherine M Chang, Austin E Wininger, Alex K Lam, Benjamen E Schoenberg, Stephen D Cederbaum, April D Pyle, James A Byrne, Gerald S Lipshutz   +14 more
doaj   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Kinetic mechanism of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase

, 2015
Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT) exhibits a kinetic mechanism that differs from that of the human homolog.
Nagappa, Lakshmeesha K., Prahladarao, Vasudeva S., Balaram, Hemalatha, Roy, Sourav   +3 more
core   +1 more source

Predicted synthetic lethals involving DHFR with thymidine and hypoxanthine in the growth medium.

, 2022
(a) 4 genetic Minimal Cut Sets (gMCSs) and 2 nutrient-genetic Minimal Cut Sets (ngMCSs) involving DHFR. They were derived from Recon3D under the RPMI1640 growth medium plus thymidine and hypoxanthine; (b) Simplified network of metabolites and enzymes ...
Xabier Agirre (143264), Francisco J. Planes (6628901), Felipe Prosper (4721076), Luis V. Valcarcel (12239953), Edurne San José-Enériz (12239950), Iñigo Apaolaza (6628892)   +5 more
core   +1 more source

Mosaic Mice with Teratocarcinoma-Derived Mutant Cells Deficient in Hypoxanthine Phosphoribosyltransferase

, 1977
MOSAIC MICE WITH TERATOCARCINOMA-DERIVED MUTANT CELLS DEFICIENT IN HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE Mosaic Mice with Teratocarcinoma-Derived Mutant Cells Deficient in Hypoxanthine Phosphoribosyltransferase (74) (-
Dewey, Michael J. David W. Martin Gail R. Martin Beatrice Mintz
core   +1 more source

The housekeeping gene hypoxanthine guanine phosphoribosyltransferase (HPRT) regulates multiple developmental and metabolic pathways of murine embryonic stem cell neuronal differentiation. [PDF]

PLoS ONE, 2013
The mechanisms by which mutations of the purinergic housekeeping gene hypoxanthine guanine phosphoribosyltransferase (HPRT) cause the severe neurodevelopmental Lesch Nyhan Disease (LND) are poorly understood.
Tae Hyuk Kang, Yongjin Park, Joel S Bader, Theodore Friedmann   +3 more
doaj   +1 more source