Results 41 to 50 of about 34,291 (223)
Trp53 Deficiency Increases the Frequency of Hprt Mutant T Lymphocytes Following High‐LET Iron Particle Irradiation of Mice [PDF]
Environ Mol MutagenABSTRACT Charged particles like iron‐56 ions impose health risks in long‐term manned space exploration. This study was designed to define the impact of Trp53 status upon the manifestation of mutations in the hypoxanthine‐guanine phosphoribosyltransferase (Hprt) gene in splenic T‐cells following exposure of Trp53 wild‐type, hemizygous, and nullizygous ...
Walker V +3 more
europepmc +2 more sources
Uric acid, an important screening tool to detect inborn errors of metabolism: a case series
BMC Research Notes, 2017 Background Uric acid is the metabolic end product of purine metabolism in humans. Altered serum and urine uric acid level (both above and below the reference ranges) is an indispensable marker in detecting rare inborn errors of metabolism.
Eresha Jasinge +10 more
doaj +1 more source
The renal phenotype of allopurinol-treated HPRT-deficient mouse.
PLoS ONE, 2017 Excess of uric acid is mainly treated with xanthine oxidase (XO) inhibitors, also called uricostatics because they block the conversion of hypoxanthine and xanthine into urate.
Cristina Zennaro +10 more
doaj +1 more source
Kinetic Studies of Hypoxanthine-Guanine Phosphoribosyltransferase
Journal of Biological Chemistry, 1968 Abstract The mechanism of reaction of human erythrocyte hypoxanthine-guanine phosphoribosyltransferase was investigated by initial velocity, product inhibition, and isotope exchange studies. Although initial velocity data are compatible with a mechanism involving binary enzyme-substrate complexes, the product inhibition and isotope exchange studies ...
J F, Henderson +4 more
openaire +2 more sources
Fine structure of the human hypoxanthine phosphoribosyltransferase gene. [PDF]
Molecular and Cellular Biology, 1986 The human hypoxanthine phosphoribosyltransferase (HPRT) gene has been characterized by molecular cloning, mapping, and DNA sequencing techniques. The entire gene, which is about 44 kilobases in length, is composed of nine exon elements. The positions of the introns within the coding sequence are identical to those of the previously-characterized mouse ...
P I, Patel +3 more
openaire +2 more sources
, 2012 Real-time PCR primer sequences for amplification of 17βHSD7 gene, and for housekeeping gene hypoxanthine phosphoribosyltransferase (HPRT).
Gang Chen (107840) +8 more
core +1 more source
, 1969 The urate pool and daily turnover of urate, together with the rate of incorporation of glycine into urate, were measured in three asymptomatic mothers who had sons with various degrees of deficiency of hypoxanthine-guanine phosphoribosyltransferase ...
Emmerson, B. T., Wyngaarden, J. B.
core +1 more source
Gas-Phase Studies of Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase (HG(X)PRT) Substrates
, 2023 The gas-phase acidity and proton affinity of nucleobases that are substrates for the enzyme Plasmodium falciparum hypoxanthine-guanine-(xanthine) phosphoribosyltransferase (Pf HG(X)PRT) have been examined using both computational and experimental methods.
Lanxin Zhang +5 more
core +1 more source
Renal Failure, 2020 Background Lesch–Nyhan disease (LND) is a rare X-linked recessive inborn error of purine metabolism. Late diagnosis of LND may cause significant morbidity. LND cases have never been reported in Indonesia.
Cahyani Gita Ambarsari +6 more
doaj +1 more source
Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV
Advanced Science, EarlyView.Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes +14 more
wiley +1 more source