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Deaminase-Driven Reverse Transcription Mutagenesis in Oncogenesis: Critical Analysis of Transcriptional Strand Asymmetries of Single Base Substitution Signatures. [PDF]

Int J Mol Sci
Steele EJ, Lindley RA.
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A multi-metabolite signature robustly predicts long-term mortality in the PREDIMED trial and several US cohorts. [PDF]

Metabolism
Fernández-Duval G, Razquin C, Wang F, Yun H, Hu J, Guasch-Ferré M, Rexrode K, Balasubramanian R, García-Gavilán J, Ruiz-Canela M, Clish CB, Corella D, Gómez-Gracia E, Fiol M, Estruch R, Lapetra J, Fitó M, Serra-Majem L, Ros E, Liang L, Dennis C, Asensio EM, Castañer O, Planes FJ, Salas-Salvadó J, Hu FB, Toledo E, Martínez-González MA.   +27 more
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Plasma Hypoxanthine and Exercise

American Review of Respiratory Disease, 1987
During exercise, ATP is converted to ADP and AMP to supply energy for muscular contraction. It is then regenerated via various pathways of intermediary metabolism. However, with high levels of exercise, net ATP degradation in muscle occurs. In exercise and other clinical situations, adenine nucleotide degradation leads to an accumulation of degradative
L H, Ketai, R H, Simon, J W, Kreit, C M, Grum   +3 more
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Partial hypoxanthine–guanine phosphoribosyl transferase deficiency without elevated urinary hypoxanthine excretion

Molecular Genetics and Metabolism, 2007
Partial hypoxanthine-guanine phosphoribosyl transferase (HGPRT) deficiency, also known as the Kelley-Seegmiller syndrome, can give rise to a wide range of neurological symptoms, and renal insufficiency. Biochemically, it is characterized by high uric acid concentrations in blood, high uric acid and hypoxanthine excretion in urine, and decreased ...
van Dael, C. M. L., Pierik, L. J. W. M., Reijngoud, D. J., Niezen-Koning, K. E., van Diggelen, O. P., van Spronsen, F. J.   +5 more
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Hypoxanthine Phosphoribosyltransferase and Hypoxanthine Uptake in Human Erythrocytes

Hoppe-Seyler´s Zeitschrift für physiologische Chemie, 1975
A system of hypoxanthine uptake and IMP retention was studied and characterized in human erythrocytes. It follows closely the system already described for rabbit erythrocytes[7]. IMP formation and retention are dependent on the activity of hypoxanthine phosphoribosyl-transferase and on intracellular availability of phosphoribosyl pyrophosphate (P-Rib ...
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Unapparent hypoxanthine-guanine phosphoribosyltransferase deficiency

Clinica Chimica Acta, 2017
Complete deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT) activity causes Lesch Nyhan disease (LND), characterized by hyperuricemia, severe action dystonia, choreoathetosis, ballismus, cognitive and attention deficit and self-injurious behavior.
R J, Torres, S, Puente, A, Menendez, N, Fernandez-Garcia   +3 more
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Hypoxanthine Transport in Human Erythrocytes

1980
De novo synthesis of purines does not appear to take place in mature human erythrocytes because the enzymes for the pathway are absent1. Therefore purine bases should be normally have to be supplied exogenously to erythrocytes.
GIACOMELLO, Alessandro, SALERNO, Costantino   +1 more
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Hypoxanthine nucleotides and muscular contraction

Biochimica et Biophysica Acta, 1963
Abstract 1. 1. Experiments have been devised to test the suggestion of a number of investigators that the interconversion of adenine and hypoxanthine nucleotides may provid the energy for muscular contraction. 2. 2. Several methods for the assay of very small amounts of these nucleotides in muscle extracts have been examined.
D F, CAIN, M J, KUSHMERICK, R E, DAVIES
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Facilitated Purification of Hypoxanthine Phosphoribosyltransferase

Hoppe-Seyler´s Zeitschrift für physiologische Chemie, 1976
Three major approaches to the complete purification of hypoxanthine phosphoribosyltransferase from human erythrocytes and rat brain are described. Preparative isoelectric focusing which has been used for the isolation of the human enzyme was not fully successful in the case of rat brain.
W, Gutensohn, M, Huber, H, Jahn
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Transport of hypoxanthine in fibroblasts with normal and mutant hypoxanthine-guanine phosphoribosyltransferase

Biochemical Medicine, 1973
Abstract Hypoxanthine transport has been studied in cultured human fibroblasts with normal and mutant H-G PRT. Transport is dependent on cell density, the activity of H-G PRT, and de novo purine synthesis. Transport is decreased in control cultures at high density and in cell strains with a mutant H-G PRT.
P J, Benke, N, Herrick, A, Herbert
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