Results 171 to 180 of about 140,789 (198)

Hypoxia Inducible Factor-1α (HIF-1α) Mediates NLRP3 Inflammasome-Dependent-Pyroptotic and Apoptotic Cell Death Following Ischemic Stroke.

Neuroscience, 2020
OBJECTIVES Stroke is a major cause of death and long-term disability. Recent evidence suggests that hypoxia-inducible factor 1α (HIF-1α), a transcription factor that regulates oxygen levels, plays a key role in neurological outcomes after ischemic stroke.
Qian Jiang, Xiaokun Geng, Johnathan Warren, Eric Eugene Paul Cosky, Shawn Kaura, Christopher R. Stone, Fengwu Li, Yuchuan Ding   +7 more
semanticscholar   +1 more source

Prognostic relevance of hypoxia inducible factor-1α expression in patients with melanoma

Clinical and Experimental Dermatology, 2009
Overexpression of hypoxia inducible factor (HIF)-1alpha has been found in several human cancers and is thought to correlate with aggressive disease and poor response. A retrospective analysis was carried out on 89 patients with primary cutaneous melanoma.
J, Valencak, H, Kittler, K, Schmid, M, Schreiber, M, Raderer, M, Gonzalez-Inchaurraga, P, Birner, H, Pehamberger   +7 more
openaire   +2 more sources

Hypoxia-inducible factor-1α: A promising therapeutic target for vasculopathy in diabetic retinopathy.

Pharmacological Research, 2020
Diabetic retinopathy (DR) is a serious condition that can cause blindness in diabetic patients. It is a neurovascular disease, but the pathogenesis leading to the onset of this disease is still not completely understood.
Hui-Yao Li, Yue Yuan, Yu-Hong Fu, Ying Wang, Xinyuan Gao   +4 more
semanticscholar   +1 more source

Hypoxia inducible factor-1α drives cancer resistance to cuproptosis.

Cancer Cell
Cuproptosis represents a new type of cell death that intricately associated with copper homeostasis and protein lipoylation. The cuproptosis suppression has been characterized in the hypoxic tumor microenvironment (TME).
Zhou Yang, Wei Su, Xiyi Wei, Yitong Pan, Mengying Xing, Lili Niu, Baijie Feng, Weiyu Kong, Xiaohan Ren, Feng Huang, Jingwan Zhou, Wei Zhao, Yingyi Qiu, Tian Liao, Qi Chen, Shuang Qu, Yunjun Wang, Qing Guan, Duanshu Li, Ke Zen, Yun Chen, Chao Qin, Yu Wang, Xiang Zhou, Jun Xiang, Bing Yao   +25 more
semanticscholar   +1 more source

Hypoxia inducible factor‐1α/vascular endothelial growth factor signaling activation correlates with response to radiotherapy and its inhibition reduces hypoxia‐induced angiogenesis in lung cancer

Journal of Cellular Biochemistry, 2018
Like other tumors, lung cancer must induce angiogenesis as it grows. Hypoxia‐inducible factor 1α (HIF‐1α) is the inducible subunit of the HIF‐1 transcription factor that regulates genes involved in the response to hypoxia, some of which contributes to ...
HongJun Zhu, Shuanglin Zhang
semanticscholar   +1 more source

Hypoxia‐inducible factor‐1α/interleukin‐1β signaling enhances hepatoma epithelial–mesenchymal transition through macrophages in a hypoxic‐inflammatory microenvironment

Hepatology, 2018
Jingying Zhang, Qi Zhang, Yu Lou, Q. Fu, Qi Chen, T. Wei, Jiaqi Yang, Jinlong Tang, Jianxin Wang, Yiwen Chen, Xiaoyu Zhang, Jian Zhang, X. Bai, T. Liang   +13 more
semanticscholar   +1 more source

Stabilization of wild-type p53 by hypoxia-inducible factor 1α

Nature, 1998
Won G. An, M. Kanekal, M. C. Simon, E. Maltepe, Mikhail V. Blagosklonny, Len Neckers   +5 more
semanticscholar   +1 more source

Cellular adaptation to hypoxia through hypoxia inducible factors and beyond

Nature Reviews Molecular Cell Biology, 2020
Pearl Lee, Navdeep S Chandel, M Celeste Simon   +2 more
exaly  

Targeting hypoxia-inducible factors: therapeutic opportunities and challenges

Nature Reviews Drug Discovery, 2023
Xiaoyi Yuan, Wei Ruan, Peter Carmeliet
exaly  

Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases

Nature Reviews Drug Discovery, 2014
Holger K Eltzschig, Sean P Colgan
exaly