Results 191 to 200 of about 1,590,992 (346)

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

Molecular and Cellular Biology, 2009
G. Bellot, Raquel García-Medina, P. Gounon, J. Chiche, D. Roux, J. Pouysségur, N. Mazure   +6 more
semanticscholar   +1 more source

From Lab to Landscape: Environmental Biohybrid Robotics for Ecological Futures

Advanced Robotics Research, EarlyView.
This Perspective explores environmental biohybrid robotics, integrating living tissues, microorganisms, and insects for operation in real‐world ecosystems. It traces the leap from laboratory experiments to forests, wetlands, and urban environments and discusses key challenges, development pathways, and opportunities for ecological monitoring and ...
Miriam Filippi
wiley   +1 more source

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Early Radiation Therapy Response Assessment Using Multi‐Scale Photoacoustic Imaging

Advanced Science, EarlyView.
Tomographic and mesoscopic photoacoustics capture intratumoural features of radioresistance and response. ABSTRACT There is a critical unmet clinical need to identify biomarkers that predict and detect radiation therapy (RT) response in cancer. Using the unique capabilities of multi‐scale photoacoustic imaging (PAI) to depict tumor oxygenation and ...
Thierry L. Lefebvre, Mariam‐Eleni Oraiopoulou, Ellie V. Bunce, Thomas R. Else, Lorna C. Wright, Monika A. Golinska, Lina Hacker, Cara Brodie, Steven Kupczak, Yi Cheng, Lisa Young, Paul W. Sweeney, Sarah E. Bohndiek   +12 more
wiley   +1 more source

Research progress on alleviating renal fibrosis by hypoxia-inducible factors

Linchuang shenzangbing zazhi
The global prevalence rate of adult chronic kidney disease （CKD） is 15%-20%， second only to hypertension and even exceeding the prevalence rate of diabetes. It is estimated that by 2040， CKD will become the fifth cause of death in the world.
Wang Jia-wang, Fan Jun, Pu Ye-fan, Chen Bo-hua, Zhang Si-han, Cao Mo-nan   +5 more
doaj  

Von Hippel-Lindau/Hypoxia Inducible Factor Axis in Glioblastoma. [PDF]

Int J Mol Sci
Flores I, Salazar A, Pérez de la Cruz V, Mena-Guerrero T, Cossio JAN, Figueroa R, Cancino-Diaz ME, Pineda B.   +7 more
europepmc   +1 more source

Regulation of hypoxia-inducible factor 1α is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

, 1998
Lei Huang, J. Gu, M. Schau, H. Bunn
semanticscholar   +1 more source

Cellular Snowballing: Cell Adhesion and Migration Drive the Self‐Assembly of Cell‐Microgel Biohybrid Spheroids

Advanced Science, EarlyView.
A new class of biohybrid spheroids is engineered through the self‐assembly of adherent cells and extracellular matrix‐mimetic hydrogel microparticles (microgels). By mimicking a snowballing effect, this approach enables scalable formation of porous, millimeter‐scale spheroids with enhanced cell viability and molecular diffusion.
Zaman Ataie, Sina Kheirabadi, Changhao Li, Aneesh Risbud, Aswathy Sebastian, Istvan Albert, Sulin Zhang, Amir Sheikhi   +7 more
wiley   +1 more source

Advances in the Research of Hypoxia-Inducible Factor-1Alpha and Plasminogen Activator Inhibitor-1 in Vascular-Related Diseases. [PDF]

J Clin Med Res
Xu X, Ge XH.
europepmc   +1 more source