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The role of hypoxia-inducible factors in cancer
Cellular and Molecular Life Sciences, 2007Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor that mediates the adaptive responses to hypoxia by effecting the transcription of numerous hypoxia-inducible genes. HIF is frequently overexpressed in solid tumors, and the transactivation of HIF targets in transformed cells provides a distinct survival advantage.
M A, Maynard, M, Ohh
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Redox regulation of the hypoxia-inducible factor
Biological Chemistry, 2006Reactive oxygen species (ROS) have long been considered only as cyto- and genotoxic. However, there is now compelling evidence that ROS also act as second messengers in response to various stimuli, such as growth factors, hormones and cytokines. The hypoxia-inducible transcription factor (HIF) is a master regulator of oxygen-sensitive gene expression ...
Pouysségur, Jacques +1 more
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Structural integration in hypoxia-inducible factors
Nature, 2015The hypoxia-inducible factors (HIFs) coordinate cellular adaptations to low oxygen stress by regulating transcriptional programs in erythropoiesis, angiogenesis and metabolism. These programs promote the growth and progression of many tumours, making HIFs attractive anticancer targets.
Dalei, Wu +4 more
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Hypoxia Induces Transcription Factor ETS-1 via the Activity of Hypoxia-Inducible Factor-1
Biochemical and Biophysical Research Communications, 2001ETS-1 plays an important role in angiogenesis and cancer invasion, and hypoxia is a common feature in these phenomena. We examined whether hypoxia influenced ETS-1 expression. Hypoxia induced ETS-1 in a human bladder cancer cell line, T24, and promoter analysis revealed that the deletion of -424 to -279 bp from the human ETS-1 promoter decreased the ...
M, Oikawa +5 more
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Hypoxia‐Inducible Factor 1 Inhibitors
2007The tremendous progress in our understanding of the molecular mechanisms underlying the presence and consequences of hypoxia in human cancers has been accompanied by renewed enthusiasm for the development of therapeutic strategies targeting hypoxic cells signaling pathways.
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Pharmacologic Targeting of Hypoxia-Inducible Factors
Annual Review of Pharmacology and Toxicology, 2019Hypoxia-inducible factors (HIFs) control transcriptional responses to reduced O 2 availability. HIFs are heterodimeric proteins composed of an O 2 -regulated HIF-α subunit and a constitutively expressed HIF-1β subunit.
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Hypoxia-inducible Factor Crosses the Checkpoint
European Urology, 2016Victoria, Lauer, Johannes, Schödel
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Hypoxia-Inducible Factor-1 Is Central to Cardioprotection
Circulation, 2008Holger Eltzschig +2 more
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