Results 271 to 280 of about 185,754 (313)

Enarodustat suppresses thymic stromal lymphopoietin expression via hypoxia-inducible factor-mediated c-Jun N-terminal kinases dephosphorylation. [PDF]

PLoS One
Segawa R, Yagisawa M, Miyata C, Hirasawa N.   +3 more
europepmc   +1 more source

Pharmacokinetics, pharmacodynamics and safety of casdatifan, a novel hypoxia-inducible factor-2α inhibitor, in healthy participants. [PDF]

Br J Clin Pharmacol
Ghasemi M, Kim JY, Seitz L, Jin L, Foster PG, Liao KH, Cheng T, Paterson E, Velinova M, Rosario NR, Khosravan R, Agoram B.   +11 more
europepmc   +1 more source

Targeted hypoxia-inducible factor 1-alpha (HIF1A) stabilization during in vitro maturation of bovine cumulus-oocyte complexes increases blastocyst rates. [PDF]

Sci Rep
Gübeli M, Bleul U, Kowalewski MP.
europepmc   +1 more source

Impact of Hypoxia-Inducible Factor-1α Gene Polymorphisms on Renal Cell Carcinoma Susceptibility in a Chinese Han Population.

Lifestyle Genom
Liao X, Zhou H, Huang P.
europepmc   +1 more source

Correction to: "Limiting Premenstrual Endometrial Hypoxia Inducible Factor 2 Alpha May Fine-Tune Endometrial Function at Menstruation".

J Clin Endocrinol Metab
europepmc   +1 more source

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Hypoxia-Inducible Factors in Cancer

Cancer Research, 2022
Abstract Low oxygen concentrations (hypoxia) are detrimental to most species on Earth; thus, cells have evolved with adaptations allowing them to withstand transient hypoxia. As with other survival pathways, cancer cells have co-opted these mechanisms to keep up with the metabolic demands of rapid growth and proliferation in harsh tumor ...
Laura C. Kim, M. Celeste Simon
openaire   +2 more sources

Hypoxia-inducible factors and cancer

Clinical and Translational Oncology, 2007
Decreased oxygen availability is a common feature during embryonic development as well of malignant tumours. Hypoxia regulates many transcription factors, and one of the most studied is the hypoxia-inducible factor (HIF). As a consequence of HIF stabilisation, the cell constitutively upregulates the hypoxic programme resulting in the expression of ...
M J, Calzada, L, del Peso
openaire   +2 more sources

Hypoxia-inducible factor in brain

2001
HIF-1 is composed of HIF-1alpha and HIF-1beta protein subunits. HIF-1 is induced by hypoxia and binds to promoter/enhancer elements and stimulates the transcription of hypoxia-inducible target genes. Because HIF-1 activation might promote cell survival in hypoxic tissues, we studied the effect of stroke on the expression of HIF-1alpha, HIF-1beta and ...
F R, Sharp, M, Bergeron, M, Bernaudin
openaire   +2 more sources

Mitochondria and Hypoxia‐induced Gene Expression Mediated by Hypoxia‐inducible Factors

Annals of the New York Academy of Sciences, 2008
The influence of mitochondrial activity on gene expression programs, particularly those involved in neuroprotection and repair, is likely to play an important role in the pathophysiology of neurodegenerative diseases. One such gene expression program is activated by the cellular pathway that senses a decrease in optimal oxygen levels and leads to ...
Angela, Chavez, Luis F, Miranda, Paola, Pichiule, Juan C, Chavez   +3 more
openaire   +2 more sources