Results 291 to 300 of about 1,590,992 (346)

Correction: Crosstalk between hypoxia-inducible factor (HIF) and lncRNAs in digestive tumors: from molecular mechanisms to clinical translation. [PDF]

Front Cell Dev Biol
Gan L, Luo P, Zou J, Li W, Chen Q, Cheng L, Zhang F, Zhong H, Lu Y, Zheng L, Qian B.   +10 more
europepmc   +1 more source

Tumor‐Derived Exosomal TAGLN2 Promotes Metastasis by Inducing Vascular Permeability and Angiogenesis via the NRP1/SEMA4D/YAP Axis

Advanced Science, EarlyView.
Gastric cancer‐derived exosomal TAGLN2 is identified as a key mediator of vascular reprogramming, with significantly elevated levels detected in patient serum. Independent of canonical SEMA4D signaling, it nucleates a cytoplasmic TAGLN2/NRP1/SEMA4D ternary complex that dually activates YAP, promoting angiogenesis, vascular dysfunction, and metastasis ...
Shuqi Yu, Jiajia Zhuo, Xiaoquan Hong, Shihao Rao, Yafang Ye, Dandan Kang, Huifang Peng, Huiqin Zhuo   +7 more
wiley   +1 more source

Investigating hypoxia-inducible factor signaling in cancer: Mechanisms, clinical implications, targeted therapeutic strategies, and resistance. [PDF]

Cancer Pathog Ther
Shaikat AH, Azad SMAK, Tamim MAR, Ullah MS, Amin MN, Sabbir MK, Tarun MTI, Mostaq MS, Sabrin S, Mahmud MZ, Mahmud MA.   +10 more
europepmc   +1 more source

POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation

Advanced Science, EarlyView.
Schematic diagram of our study showing that highly expressed POU2F1 in colorectal cancer (CRC) can directly accelerate the cytosolic lactate export to decrease PPP1R11 lactylation at K59, thereby attenuating the E3 ligase enzyme activity and protein stability of PPP1R11, which inhibits the ubiquitination of MDR2 at K413 and K538 but increases the ...
Longzheng Xia, Jinguan Lin, Xianjie Jiang, Linda Oyang, Shiming Tan, Zongyao Ren, Qiu Peng, Qianjin Liao, Yujuan Zhou   +8 more
wiley   +1 more source

Alpha-ketoglutarate enhances adipose-derived stem cells survival in wound healing by hypoxia-inducible factor 1-alpha-mediated redox homeostasis and glycogen-dependent bioenergetics. [PDF]

World J Stem Cells
Dilimulati D, Dilimulati D, Cui L.
europepmc   +1 more source

[Retracted] Expression and clinical significance of hypoxia‑inducible factor 1α, Snail and E‑cadherin in human ovarian cancer cell lines. [PDF]

Mol Med Rep
Zhang Y, Fan N, Yang J.
europepmc   +1 more source

Hypoxia and activation of hypoxia inducible factor alpha as influencers of inflammatory helper T cells in autoimmune disease - a link between cancer and autoimmunity. [PDF]

Front Immunol
Almanzar G, Alarcon JC, Garzon R, Navarro AM, Ondo-Méndez A, Prelog M.   +5 more
europepmc   +1 more source

Crosstalk between the aryl hydrocarbon receptor and hypoxia-inducible factor 1α pathways in human islet models. [PDF]

Islets
Gang N, van Allen KA, Willmore WG, Lynn FC, Bruin JE.   +4 more
europepmc   +1 more source

Hypoxia-inducible factor-1α promotes tubulointerstitial fibrosis via the upregulation of <i>Muc4</i>. [PDF]

Ren Fail
Li ZT, Hu XH, Ni WJ, Li ZL, Huang BK, Zhang Y, Miao AF, Cao JY.   +7 more
europepmc   +1 more source

Impact of Chronic Stress and Anxiety on Interleukin-6, Hypoxia-Inducible Factor-1α and on Pathological and Immunohistochemical Parameters in Breast Cancer. [PDF]

Asian Pac J Cancer Prev
Yahia S, Tahari Z, Medjdoub A, Bessaih N, Messatfa M, Lahmer M, Seddiki S, Sahraoui T.   +7 more
europepmc   +1 more source