Results 301 to 310 of about 1,590,992 (346)
J Clin Endocrinol MetabSome of the next articles are maybe not open access.
Related searches:
Related searches:
Hypoxia-Inducible Factors in Cancer
Cancer Research, 2022Abstract Low oxygen concentrations (hypoxia) are detrimental to most species on Earth; thus, cells have evolved with adaptations allowing them to withstand transient hypoxia. As with other survival pathways, cancer cells have co-opted these mechanisms to keep up with the metabolic demands of rapid growth and proliferation in harsh tumor ...
Laura C. Kim, M. Celeste Simon
openaire +2 more sources
The role of hypoxia‐inducible factor 1 in tumor immune evasion
Medicinal research reviews (Print), 2020Hypoxia‐inducible factor 1 (HIF‐1) plays an indispensable role in the hypoxic tumor microenvironment. Hypoxia and HIF‐1 are involved in multiple aspects of tumor progression, such as metastasis, angiogenesis, and immune evasion.
L. You +7 more
semanticscholar +1 more source
Hypoxia-inducible factors and cancer
Clinical and Translational Oncology, 2007Decreased oxygen availability is a common feature during embryonic development as well of malignant tumours. Hypoxia regulates many transcription factors, and one of the most studied is the hypoxia-inducible factor (HIF). As a consequence of HIF stabilisation, the cell constitutively upregulates the hypoxic programme resulting in the expression of ...
M J, Calzada, L, del Peso
openaire +2 more sources
Hypoxia-inducible factor in brain
2001HIF-1 is composed of HIF-1alpha and HIF-1beta protein subunits. HIF-1 is induced by hypoxia and binds to promoter/enhancer elements and stimulates the transcription of hypoxia-inducible target genes. Because HIF-1 activation might promote cell survival in hypoxic tissues, we studied the effect of stroke on the expression of HIF-1alpha, HIF-1beta and ...
F R, Sharp, M, Bergeron, M, Bernaudin
openaire +2 more sources
Mitochondria and Hypoxia‐induced Gene Expression Mediated by Hypoxia‐inducible Factors
Annals of the New York Academy of Sciences, 2008The influence of mitochondrial activity on gene expression programs, particularly those involved in neuroprotection and repair, is likely to play an important role in the pathophysiology of neurodegenerative diseases. One such gene expression program is activated by the cellular pathway that senses a decrease in optimal oxygen levels and leads to ...
Angela, Chavez +3 more
openaire +2 more sources
Hypoxia-Inducible Factor-1 (HIF-1)
Molecular Pharmacology, 2006Adaptation to low oxygen tension (hypoxia) in cells and tissues leads to the transcriptional induction of a series of genes that participate in angiogenesis, iron metabolism, glucose metabolism, and cell proliferation/survival. The primary factor mediating this response is the hypoxia-inducible factor-1 (HIF-1), an oxygen-sensitive transcriptional ...
Qingdong, Ke, Max, Costa
openaire +2 more sources
Hypoxia‐Inducible Factor 1 Inhibitors
2007The tremendous progress in our understanding of the molecular mechanisms underlying the presence and consequences of hypoxia in human cancers has been accompanied by renewed enthusiasm for the development of therapeutic strategies targeting hypoxic cells signaling pathways.
openaire +2 more sources
Structural integration in hypoxia-inducible factors
Nature, 2015The hypoxia-inducible factors (HIFs) coordinate cellular adaptations to low oxygen stress by regulating transcriptional programs in erythropoiesis, angiogenesis and metabolism. These programs promote the growth and progression of many tumours, making HIFs attractive anticancer targets.
Dalei, Wu +4 more
openaire +2 more sources