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Hypoxia Induces Transcription Factor ETS-1 via the Activity of Hypoxia-Inducible Factor-1
Biochemical and Biophysical Research Communications, 2001ETS-1 plays an important role in angiogenesis and cancer invasion, and hypoxia is a common feature in these phenomena. We examined whether hypoxia influenced ETS-1 expression. Hypoxia induced ETS-1 in a human bladder cancer cell line, T24, and promoter analysis revealed that the deletion of -424 to -279 bp from the human ETS-1 promoter decreased the ...
M, Oikawa +5 more
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Pharmacologic Targeting of Hypoxia-Inducible Factors
Annual Review of Pharmacology and Toxicology, 2019Hypoxia-inducible factors (HIFs) control transcriptional responses to reduced O 2 availability. HIFs are heterodimeric proteins composed of an O 2 -regulated HIF-α subunit and a constitutively expressed HIF-1β subunit.
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Targeting hypoxia-inducible factors: therapeutic opportunities and challenges
Nature Reviews Drug Discovery, 2023Xiaoyi Yuan, Wei Ruan, Peter Carmeliet
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Hypoxia-Inducible Factor 2 Alpha (HIF2α) Inhibitors: Targeting Genetically Driven Tumor Hypoxia
Endocrine Reviews, 2023Camilo Jimenez, Patricia L M Dahia
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Renal anemia: Hypoxia inducible factor stabilizers
Medicina Clínica (English Edition), 2023Nicolás Roberto, Robles +1 more
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Cellular adaptation to hypoxia through hypoxia inducible factors and beyond
Nature Reviews Molecular Cell Biology, 2020Pearl Lee +2 more
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