Results 161 to 170 of about 33,359,923 (277)

Neurotrophic Signaling, Sleep Physiology, and Retinal Neuroprotection: Integrative Mechanisms and Therapeutic Implications for Glaucoma

Sensory Neuroscience, EarlyView.
Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa, Emiliano Terán, Javier A. Magaña‐Gómez, Loranda Calderón‐Zamora, Beatriz K. De la Herrán‐Arita, Alberto K. De la Herrán‐Arita   +5 more
wiley   +1 more source

Short-Term Effects of Intradialytic Hypoxemia on Plasma Markers of Hypoxia. [PDF]

Int J Mol Sci
Korzycka J, Pęczek-Bartyzel K, Nowicki M.   +2 more
europepmc   +1 more source

Smart mesoporous silica nanoparticles for precision cancer therapy: Tumor targeting and stimuli‐responsive controlled release

Smart Molecules, EarlyView.
Smart mesoporous silica nanoparticles integrate tunable pore structures, molecular gates, targeting ligands, and stimuli‐responsive components to achieve controlled drug release for precision cancer therapy. This review highlights design principles, therapeutic applications, and future directions in immunotherapy, biodegradability, biosafety, and ...
Majdi Al‐Amili, Lei Lei, Zhu Jin
wiley   +1 more source

Commentary: Neutral Commentary on Frontiers Article “Cobalt Chloride Upregulates Impaired HIF-1α Expression to Restore Sevoflurane Post-conditioning-Dependent Myocardial Protection in Diabetic Rats”

Frontiers in Physiology, 2017
Nila Ghanei, Rajesh H. Amin
doaj   +1 more source

Role of Hypoxia-Inducible Factor-1α in Regulating Muscle Degeneration After Rotator Cuff Tears. [PDF]

Am J Sports Med
Zhang H, Lee A, Liu M, Diaz A, Zhang Y, Kim HT, Feeley BT, Liu X.   +7 more
europepmc   +1 more source

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

Integrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang Chen   +6 more
wiley   +1 more source

Paeonol's protective effects on H9C2 cells against hypoxia/ reoxygenation injury through the hypoxia-inducible factor 1-alpha/B-cell lymphoma-2/adenovirus E1B 19 kDa interacting protein 3 signaling pathway. [PDF]

J Tradit Chin Med
Chengguo Z, Meifang Y, Menghan Z, Shuzhi Q.   +3 more
europepmc   +1 more source

Genomic Investigations Unveil the Genetic Underpinnings of Environmental Adaptation in African Goat Populations

Integrative Zoology, EarlyView.
This study integrates genomics and landscape genetics to analyze African goat environmental adaptation. Analyzing 1591 samples, it finds population structure differentiates geographically into four groups, with gene flow between wild Yura goats and North Africans.
Weifeng Peng, Yihua Wang, Yiyuan Zhang, Lei Gao, Lili Wu, Shuping Wang, Yiyang Gao, Wanlu Shi, Kaixin Lu, Rong Deng, Junting Li, Jing Han, Xiaohui Lu, Yujie Liu, Xiaojiao Tang, Yunxia Zhang, Guoyin Li, Li Huang, Mingsheng Yang, Xiaoyan Li   +19 more
wiley   +1 more source

The effect of hypoxia and the transcription factor hypoxia inducible factor-1 (HIF-1) on metastasis

, 2008
Tumour hypoxia has been widely implicated in the development of aggressive, therapy resistant malignant disease. Patients presenting with more hypoxic tumours experience higher levels of mortality compared to those with lower levels of hypoxia.
Knight, Laura K
core  

Mrpl50 integrates glucolipotoxicity with hypoxia-inducible factor 1 alpha signaling to drive diabetic kidney disease. [PDF]

J Biol Chem
Li J, Liu R, Wang W, Zhang T, Kong Y, Jiang Q, Meng D, Cui S, Zhu S.   +8 more
europepmc   +1 more source