Results 171 to 180 of about 56,007 (232)

Iron Chelators in the Management of Autoimmune-Induced Alopecia: A Focus on Hypoxia-Inducible Factor 1 Modulation and Hair Restoration. [PDF]

J Clin Med
Pagani A, Thor D, Panayi AC, Klein SM, Geis S, Knoedler L, Knoedler S, Perozzo FAG, Sofo G, Loucas R, Prantl L, Duscher D.   +11 more
europepmc   +1 more source

Fibrotic Fortresses and Therapeutic Frontiers: Pancreatic Stellate Cells and the Extracellular Matrix in Pancreatic Cancer

Cancer Medicine, Volume 14, Issue 11, June 2025.
ABSTRACT Background Pancreatic ductal adenocarcinoma (PDAC) is characterized by a unique tumor microenvironment (TME) that plays pivotal roles in cancer progression, angiogenesis, metastasis, and drug resistance. This complex and dynamic ecosystem comprises cancer cells, stromal cells, and extracellular matrix (ECM) components, which interact ...
Sila Sigirli, Didem Karakas
wiley   +1 more source

The serum proteomic profile in patients with migraine. [PDF]

Front Mol Neurosci
Han Y, Wang Y, Zou X, Guo H.
europepmc   +1 more source

Recent Findings in N6‐Methyladenosine Modification and Significance in Pancreatic Cancer

Cancer Medicine, Volume 14, Issue 11, June 2025.
ABSTRACT Background RNA modifications are widely detected in cells and are involved in RNA structural stabilization and regulation of gene expression. In cancer cells, RNA modifications are altered, resulting in abnormal expression of numerous genes and promoting cancer growth. N1‐methyladenosine (m1A), N6‐methyladenosine (m6A), N3‐methylcytosine (m3C),
Tomoaki Hara, Sikun Meng, Yasuko Arao, Yoshiko Saito, Kana Inoue, Sarah Rennie, Ken Ofusa, Toru Kitagawa, Hideshi Ishii   +8 more
wiley   +1 more source

ELAVL1 promotes ferroptosis via the TRIM21/HOXD8 axis to inhibit osteogenic differentiation in congenital pseudoarticular tibia‐derived mesenchymal stem cells

Journal of Cell Communication and Signaling, Volume 19, Issue 2, June 2025.
Abstract Osteogenic differentiation of mesenchymal stem cells (MSCs) was strongly correlated with the progression of congenital tibial pseudoarthrosis (CPT). Activation of ferroptosis inhibited osteogenic differentiation of MSCs. ELAV‐like RNA binding protein 1 (ELAVL1) is a key factor in promoting ferroptosis.
Weihua Ye, Zheng Liu, Yaoxi Liu, Han Xiao, Qian Tan, An Yan, Guanghui Zhu   +6 more
wiley   +1 more source

Upregulation of astrocytic mitochondrial functions via Korean red ginseng-induced CREB-BK<b>α</b>-HIF-1<b>α</b> axis through L-type Ca²⁺ channel subunits <b>α</b>1C and <b>β</b>4. [PDF]

J Cereb Blood Flow Metab
Kim H, Moon S, Kim M, Oh H, Park J, Kim S, Yoo T, Kim JY, Kim Y, Kim YM, Choi YK.   +10 more
europepmc   +1 more source

The Potential Role of Egg‐Derived Xeno‐miRs in Chemotherapy Response: An In Silico Approach

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
Dietary microRNAs (Xeno‐miRs), especially those homologous to human miRNAs found in animal‐based foods, may influence chemotherapy responses across cancer types. This study highlights the underexplored potential of human homolog egg‐derived Xeno‐miRs as biomarkers and therapeutic targets.
Berkcan Doğan
wiley   +1 more source

Antitumor effects of dauricine on sorafenib-treated human lung cancer cell lines via modulation of HIF-1α signaling pathways. [PDF]

Med Oncol
Teleb EK, Mehanna RA, Assem NM, Houssen ME.   +3 more
europepmc   +1 more source

Identification and Validation of Circadian Rhythm‐Related Genes Involved in Intervertebral Disc Degeneration and Analysis of Immune Cell Infiltration via Machine Learning

JOR SPINE, Volume 8, Issue 2, June 2025.
Within this manuscript, bioinformatics and experimental methods are used to explore the role of circadian rhythm and immunity in Intervertebral Disc Degeneration (IVDD). CCND1, FOXO1, FRMD8, NTRK2, PRRT1, and TFPI were successfully demonstrated to be hub rhythm‐related genes in the process of IVDD together with immunity.
Yongbo Zhang, Liuyang Chen, Sheng Yang, Rui Dai, Hua Sun, Liang Zhang   +5 more
wiley   +1 more source

Association of SIRT6 Expression With Risk of Pneumonitis Induced by Radiotherapy in Cancer Patients

Molecular Carcinogenesis, Volume 64, Issue 6, Page 1104-1118, June 2025.
ABSTRACT Thoracic tumours represent a significant proportion of malignant cancers. While radiotherapy (RT) improves prognosis, it can also lead to side effects such as radiation‐induced pneumonitis (RP). Since SIRT6 is involved in DNA repair, energy metabolism and inflammation, this study aims to investigate the expression of SIRT6 in lymphocytes as a ...
Fengyuan Yu, Zheng Gong, Yuan Li, Danial F. Naseem, Chen Li, Miaowei Wen, Bingying Zhao, Zhezhe Xu, Shanshan Zhang, Rukun Zang, Ailu Wu, Qingxin Han, Shuhui Wu, Hongwei Li, Yipeng Song   +14 more
wiley   +1 more source