Results 81 to 90 of about 65,592 (181)

The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching [PDF]

, 2013
Significance: a mismatch between energy supply and demand induces tissue hypoxia with the potential to cause cell death and organ failure. Whenever arterial oxygen concentration is reduced, increases in blood flow - 'hypoxic vasodilation' - occur in an ...
Alex Dyson, Audibert G, Berne RM, Blitzer ML, Boutilier RG, Brown IP, Devlin C, Furukawa K, Hall JE, Heyes MP, Jekabsone A, Lehninger A, Leone AM, Louis CA, Martin Feelisch, Mervyn Singer, Michele Umbrello, Modin A, Munk VC, Pohl U, Rengasamy A, Rengasamy A, Vallance P, Whorton AR   +23 more
core   +1 more source

Allogeneic mesenchymal stromal cells overexpressing mutant human Hypoxia-inducible factor 1-α (HIF1-α) in an ovine model of acute myocardial infarction [PDF]

, 2016
Background-Bone marrow mesenchymal stromal cells (BMMSCs) are cardioprotective in acute myocardial infarction (AMI) because of release of paracrine angiogenic and prosurvival factors.
Crottogini, Alberto José, De Lorenzi, Andrea, Giménez, Carlos Sebastián, Hnatiuk, Anna, Jen, Cheng Hao, Laguens, Rubén, Lee, Won Hee, Locatelli, Paola, Olea, Fernanda Daniela, Ong, Sang-Ging, Riegler, Johannes, Wu, Joseph C.   +11 more
core   +1 more source

Crossroads between peripheral atherosclerosis, western-type diet and skeletal muscle pathophysiology: emphasis on apolipoprotein E deficiency and peripheral arterial disease [PDF]

, 2017
Atherosclerosis is a chronic inflammatory process that, in the presence of hyperlipidaemia, promotes the formation of atheromatous plaques in large vessels of the cardiovascular system.
Matsakas, Antonios, Sfyri, Peggy
core   +1 more source

Hypoxia-induced ATF3 escalates breast cancer invasion by increasing collagen deposition via P4HA1

Cell Death and Disease
Activating transcription factors (ATFs), members of the adaptive-response gene family, participate in cellular processes to aid adaptations in response to extra and/or intracellular changes.
Shruti Ganesh Dhamdhere, Anamika Bansal, Pranjal Singh, Parik Kakani, Shruti Agrawal, Atul Samaiya, Sanjeev Shukla   +6 more
doaj   +1 more source

Tissue-Specific Orchestration of Gilthead Sea Bream Resilience to Hypoxia and High Stocking Density [PDF]

, 2019
Two different O-2 levels (normoxia: 75-85% O-2 saturation; moderate hypoxia: 42-43% O-2 saturation) and stocking densities (LD: 9.5, and HD: 19 kg/m(3)) were assessed on gilthead sea bream (Sparus aurata) in a 3-week feeding trial.
Ackerman, Alfaro, Almeida, Araújo-Luna, Arends, Ashley, Auer, Balasch, Benedito-Palos, Benedito-Palos, Benedito-Palos, Bergan-Roller, Bermejo-Nogales, Bermejo-Nogales, Bermejo-Nogales, Brett, Brown-Borg, Brown-Borg, Cadiz, Cadiz, Calduch-Giner, Calduch-Giner, Calduch-Giner, Dam, Deutsch, Du, Ekau, Estensoro, Everett, Føre, Gallaugher, Garcia de la Serrana, Gil-Solsona, Gómez-Requeni, Hermes-Lima, Hopkins, Huang, Hulbert, Hulbert, Jensen, Jørgensen, Kajimura, Ke, Kieffer, Lai, Larsen, Li, Livak, Lushchak, Magnoni, Martin, Martos-Sitcha, Martos-Sitcha, Martos-Sitcha, Martínez-Barberá, Martínez-Porchas, McKenzie, Millán-Cubillo, Minchenko, Mommsen, Monternier, Montero, Mosconi, Murray, Nikinmaa, Nikinmaa, Nilsson, Pauletto, Pearson, Person-Le Ruyet, Piazzon, Piazzon, Pichavant, Pickering, Poulain, Pérez-Sánchez, Pérez-Sánchez, Pérez-Sánchez, Pérez-Sánchez, Pérez-Sánchez, Reindl, Remen, Remen, Richards, Rimoldi, Rodrigues, Rolfe, Ruer, Salin, Sangiao-Alvarellos, Saravanan, Shimizu, Simó-Mirabet, Simó-Mirabet, Simó-Mirabet, Skrzynska, Soivio, Speckner, Treins, Val, Valli, Van Weerd, Vega-Rubín de Celis, Vijayan, Vikeså, Vélez, Wells, Wendelaar Bonga, Wold, Wood, Yu, Yáñez, Yúfera, Zhu   +113 more
core   +3 more sources

The endogenous hallucinogen and trace amine N,N-dimethyltryptamine (DMT) displays potent protective effects against hypoxia via sigma-1 receptor activation in human primary iPSC-derived cortical neurons and microglia-like immune cells

Frontiers in Neuroscience, 2016
N,N-dimethyltryptamine (DMT) is a potent endogenous hallucinogen present in the brain of humans and other mammals. Despite extensive research, its physiological role remains largely unknown.
Attila Szabo, Attila Szabo, Attila Szabo, Attila Kovacs, Jordi Riba, Jordi Riba, Srdjan Djurovic, Srdjan Djurovic, Eva Rajnavolgyi, Ede Frecska   +9 more
doaj   +1 more source

Upregulation of miR-335 ameliorates myocardial ischemia reperfusion injury via targeting hypoxia inducible factor 1-alpha subunit inhibitor.

American journal of translational research
MicroRNA-335 (miR-335) is implicated in several pathophysiological processes, including tumorigenesis, lipid metabolism and ischemic stroke; however, whether miR-335 plays a role in modulating myocardial ischemia reperfusion injury (MIRI) is still unknown.
Nan, Wu, Xiaowen, Zhang, Shuyan, Du, Dong, Chen, Ruichao, Che   +4 more
openaire   +1 more source

Hepatocellular carcinoma: Review of disease and tumor biomarkers. [PDF]

, 2016
© The Author(s) 2016.Hepatocellular carcinoma (HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative
Cox, IJ, Crossey, MM, Fye, HK, Gomez-Romero, M, Holmes, E, Kim, JU, Njie, R, Shariff, MI, Taylor-Robinson, SD   +8 more
core   +1 more source

Vulnerability of Gastric Mucosa to Prednisolone in Rats Chronically Exposed to Cigarette Smoke

Journal of Pharmacological Sciences, 2008
We examined gastric mucosal vulnerability in a rat model of chronic obstructive pulmonary disease (COPD). Male Wistar rats were exposed to cigarette smoke for 12 weeks (CSE rats), and on the last 4 days of exposure, prednisolone was given to induce ...
Yoshiaki Takeuchi, Maki Takahashi, Jun-ichi Fuchikami   +2 more
doaj   +1 more source

Estrogen receptor 1 (ESR1) regulates VEGFA in adipose tissue

Scientific Reports, 2017
Vascular endothelial growth factor A (VEGFA) is a key factor in the regulation of angiogenesis in adipose tissue. Poor vascularization during adipose tissue proliferation causes fibrosis and local inflammation, and is associated with insulin resistance ...
L. A. Fatima, R. S. Campello, R. de Souza Santos, H. S. Freitas, A. P Frank, U. F. Machado, D. J. Clegg   +6 more
doaj   +1 more source