Results 91 to 100 of about 33,359,923 (277)

Gαi1/3 Are Essential for BMP2‐Induced Osteogenesis by Bridging BMP Receptors to the Gab1 Signaling Complex

Advanced Science, EarlyView.
The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan, Chaowen Bai, Yifei Zhu, Chenyang Xu, Sonngtao Li, Qize Sun, Chang She, Jinyu Bai, Cong Cao, Yitian Yang, Xiaozhong Zhou   +10 more
wiley   +1 more source

Mouse models for preeclampsia: disruption of redox-regulated signaling [PDF]

, 2009
The concept that oxidative stress contributes to the development of human preeclampsia has never been tested in genetically-defined animal models. Homozygous deletion of catechol-Omethyl transferase (Comt-/-) in pregnant mice leads to human preeclampsia ...
Chambers, Anne E., Banerjee, Subhasis, Randeva, Harpal S., Randeva Harpal, Harpal Randeva, Banerjee Subhasis, Anne E Chambers, Chambers Anne E, Subhasis Banerjee   +8 more
core   +1 more source

Digoxin attenuates LPS-induced acute lung injury in mice via NF-κB and HIF-1α inhibition

Biomolecules & Biomedicine
Acute lung injury (ALI), which can progress to the highly lethal acute respiratory distress syndrome (ARDS), remains a condition with limited pharmacological interventions, highlighting the urgent need for mechanism-informed repurposing strategies ...
Abdulaziz M. Alzahrani, Mai A. Alim A. Sattar Ahmad, Wafaa S. Ramadan, Huda M. Alkreathy   +3 more
doaj   +1 more source

Intratumoral Hypoxia Triggers Mitochondrial BHLHE40 ROS Sensing Pathway to Promote Radioresistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Hypoxia triggers a dual mechanism for BHLHE40 upregulation: reactive oxygen species (ROS)‐dependent post‐translational modification and hypoxia‐inducible factor (HIF)‐dependent transcriptional activation. Under hypoxic conditions, mitochondrial BHLHE40 accumulates and senses ROS via cysteine thiol oxidation and disulfide‐linked homodimer formation ...
Jia Liu, Ziliang Nie, Xi Chen, Guangyu Ji, Yajing Zhang, Zhiqun Zhao, Yuhong Zhang, Xinlong Du, Zhenzhen Zhou, Jiayi Li, Yaozong Yang, Fengqi Sun, Zhibo Yan, Haiquan Lu   +13 more
wiley   +1 more source

Divergent modulation of iron regulatory proteins and ferritin biosynthesis by hypoxia/reoxygenation in neurons and glial cells [PDF]

, 2006
Il ferro è il metallo di transizione più abbondante nel sistema nervoso centrale in quanto cofattore di enzimi eminici e non-eminici coinvolti nel metabolismo energetico cellulare.
Maffettone, Carmen
core   +1 more source

Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat [PDF]

, 2012
The main goal of adequate organ preservation is to avoid further cellular metabolism during the phase of ischemia. However, modern preservation solutions do rarely achieve this target.
Paulus, Patrick, Tacke Sabine, Johannes Holfeld, Karnowski Nora, Patrick Paulus, Holfeld, Johannes, Urbschat, Anja, Urbschat Anja, Zacharowski, Kai, Tacke, Sabine, Ockelmann, Pia, Nora Karnowski, Karnowski, Nora, Bertram Scheller, Scheller, Bertram, Pia Ockelmann, Ellinghaus, Peter, Paulus Patrick, Zacharowski Kai, Sabine Tacke, Ellinghaus Peter, Anja Urbschat, Kai Zacharowski, Peter Ellinghaus, Ockelmann Pia, Scheller Bertram, Holfeld Johannes   +26 more
core   +2 more sources

Hypoxia Inducible Factor-1 Alpha as a Diagnostic Marker in Early Diabetic Nephropathy

Biomedical and Biotechnology Research Journal
Background: Research on the diagnostic utility of hypoxia-inducible factor-1 alpha (HIF-1α) as an indicator of diabetic kidney disease (DKD) in the Indian population is lacking.
Shriya Narendra Shet Shirodkar, Sindhu, Poornima Ajay Manjrekar, Neelam M Pawar, Sowndarya Kollampare, Janice Dsa   +5 more
doaj   +1 more source

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source

Regulation of the Rgs4 gene by the hypoxia inducible factors. [PDF]

, 2012
The transcriptional response to hypoxia is critically dependent on the Hypoxia Inducible Factors HIF-1 and HIF-2, which have roles not only in development and cellular adaptation to low oxygen levels, but also in diseases such as cancer.
Olechnowicz, Sam
core  

Mechanisms Of Hypoxia-Induced Immune Escape In Cancer And Their Regulation By Nitric Oxide

Redox Biology, 2015
The acquired ability of tumour cells to avoid destruction by immune effector mechanisms (immune escape) is important for malignant progression. Also associated with malignant progression is tumour hypoxia, which induces aggressive phenotypes such as ...
Charles Graham, Ivraym Barsoum, Judy Kim, Madison Black, Robert D. Siemens   +4 more
doaj   +1 more source