Results 111 to 120 of about 65,547 (283)

The proangiogenic capacity of polymorphonuclear neutrophils delineated by microarray technique and by measurement of neovascularization in wounded skin of CD18-deficient mice [PDF]

, 2006
Growing evidence supports the concept that polymorphonuclear neutrophils (PMN) are critically involved in inflammation-mediated angiogenesis which is important for wound healing and repair.
Addison CL, Armstrong DA, Baggiolini M, Barbara Walzog, Bazzoni F, Benelli R, Bernardini G, Bohnsack JF, Brandes ME, Cacalano G, Choudhuri R, Devalaraja RM, Dewald B, Dubravec DB, Gasperini S, Gaudry M, Grant DS, Grenier A, Grotendorst GR, Harada H, Heiple JM, Ikematsu S, Iruela-Arispe ML, John A, Jürgen Schymeinsky, Karin Scharffetter-Kochanek, Kreis C, Kullander K, Liu XH, Loukinova E, Matzner Y, Muramaki M, Niiro H, Oda N, Pertovaara L, Ramchandran R, Roberts AB, Ruth Schruefer, Sang QX, Sato W, Scapini P, Scharffetter-Kochanek K, Schruefer R, Sehgal I, Semenza GL, Shapiro SD, Silke Sulyok, Takada T, Takada T, Tasiemski A, Thorsten Peters, Triebel S, Walzog B, Wang SC, Willeke T, Yoshida S   +55 more
core   +1 more source

Reduction of Ribonucleotide Reductase Subunit RRM2 Potentially Impairs Gut Function of Woody Breast Broilers

Animal Research and One Health, EarlyView.
Woody breast compromises meat quality leading to reduced consumer appeal. Although its causes are unclear, improvements observed with certain dietary supplements suggest that gut health may influence woody breast development. Ribonucleotide reductase subunit RRM2 is vital for mitochondrial function and gastrointestinal integrity, and alteration in its ...
Majid Shakeri, Elizabeth Ziabtchenko, Janghan Choi, Caitlin E. Harris, Richard J. Buhr, Trevor R. Mitchell, Byungwhi Kong, Hong Zhuang, Brian Bowker   +8 more
wiley   +1 more source

Expression profiling of laser-microdissected intrapulmonary arteries in hypoxia-induced pulmonary hypertension [PDF]

, 2005
Background Chronic hypoxia influences gene expression in the lung resulting in pulmonary hypertension and vascular remodelling. For specific investigation of the vascular compartment, laser-microdissection of intrapulmonary arteries was combined with ...
G Semenza, CP Bracken, RH Wenger, GL Semenza, AY Yu, LA Shimoda, RM Tuder, D Katayose, SS Arcot, JT Berg, S Archer, AA Alizadeh, DG Beer, Y Hoshikawa, L Fink, L Luo, V Luzzi, L Fink, L Fink, L Fink, KJ Livak, C Leethanakul, H Ohyama, DC Sgroi, GF Steward, V Sharov, CA Heid, J Wilhelm, E Talla, Y Cai, MD Botney, M Hidalgo, G Bultynck, MD Tilson, M Oelze, M Krause, AJ Hance, IF McMurtry, A Ouiddir, DG Hardie, XC Jiang, PW Hochachka, S Tinton, M Rabinovitch, KR Stenmark, M Rabinovitch, S Greenway, A Lawrie, T Yehualaeshet, S Khatua, SV Smirnov, SL Archer, T Uchida, I Kvietikova, GL Semenza   +54 more
core   +2 more sources

The Role of Microbiota Metabolites Propionic Acid, p‐Cresol, and 4‐Ethylphenyl Sulfate in Autism Susceptibility: A Systematic Review

Autism Research, EarlyView.
ABSTRACT The etiopathogenesis of Autism Spectrum Disorder (ASD) encompasses complex interactions between genetic and environmental risk factors. The high prevalence of gastrointestinal disorders in autistic individuals has propelled a growing interest in the possible involvement of gut dysbiosis in ASD pathogenesis.
Laura Sandoni, Lisa Asta, Nicole Giompaolo, Rinvil Renaldi, Alberto Amaretti, Maddalena Rossi, Antonio M. Persico   +6 more
wiley   +1 more source

Hypoxia-induced ATF3 escalates breast cancer invasion by increasing collagen deposition via P4HA1

Cell Death and Disease
Activating transcription factors (ATFs), members of the adaptive-response gene family, participate in cellular processes to aid adaptations in response to extra and/or intracellular changes.
Shruti Ganesh Dhamdhere, Anamika Bansal, Pranjal Singh, Parik Kakani, Shruti Agrawal, Atul Samaiya, Sanjeev Shukla   +6 more
doaj   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Quantum blue reduces the severity of Woody Breast myopathy via modulation of oxygen homeostasis-related genes in broiler chickens [PDF]

, 2019
The incidence of woody breast (WB) is increasing on a global scale representing a significant welfare problem and economic burden to the poultry industry and for which there is no effective treatment due to its unknown etiology.
Altamirano, Bernal, Bernal, Biagioli, Bkaily, Cadiz, Cain, Chappell, Chatterjee, Chen, Dadgar, Derbal-Wolfrom, Dhar, Ema, Epstein, Fedorova, Ferreira, Flees, Gingras, Gorr, Gorr, Grek, Guo, Harms, Harter, Irrcher, Isaacson, Jiang, Kaps, Keith, Kim, Kim, Kuttappan, Kuttappan, Kuttappan, Land, Lee, Lee, Liu, Majmundar, Mallmann, Martin, Mehta, Mijares, Mourant, Mudalal, Mudalal, Mutryn, Nakazawa, Nguyen, Nguyen, Nichols, Ohyagi, Orlowski, Peatman, Petracci, Rajaram, Saito, Schaal, Schelshorn, Schmittgen, Sediame, Shi, Sihvo, Soglia, Stockard, Tasoniero, Terwilliger, Treins, Vishwanath, Washburn, Weber, Weiss, Wride, Xia, Yadav   +75 more
core   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Enhanced strategies for cuproptosis‐like death in bacterial infection treatment

BMEMat, EarlyView.
This review summarizes and examines the molecular mechanisms underlying cuproptosis‐like death. Furthermore, multi‐strategy efficacy enhancement and potential enhancement approaches are analyzed. Abstract Copper, a classical antibacterial metal, has long been of interest and widely used in medical and public health applications.
Wenqi Wang, Bolong Xu, Ruiyuan Zhu, Hengshuo Gui, Tian Xia, Shaokai Liu, Huiyu Liu, Xianwen Wang   +7 more
wiley   +1 more source

The endogenous hallucinogen and trace amine N,N-dimethyltryptamine (DMT) displays potent protective effects against hypoxia via sigma-1 receptor activation in human primary iPSC-derived cortical neurons and microglia-like immune cells

Frontiers in Neuroscience, 2016
N,N-dimethyltryptamine (DMT) is a potent endogenous hallucinogen present in the brain of humans and other mammals. Despite extensive research, its physiological role remains largely unknown.
Attila Szabo, Attila Szabo, Attila Szabo, Attila Kovacs, Jordi Riba, Jordi Riba, Srdjan Djurovic, Srdjan Djurovic, Eva Rajnavolgyi, Ede Frecska   +9 more
doaj   +1 more source