Results 111 to 120 of about 35,931 (278)

Enhanced strategies for cuproptosis‐like death in bacterial infection treatment

BMEMat, EarlyView.
This review summarizes and examines the molecular mechanisms underlying cuproptosis‐like death. Furthermore, multi‐strategy efficacy enhancement and potential enhancement approaches are analyzed. Abstract Copper, a classical antibacterial metal, has long been of interest and widely used in medical and public health applications.
Wenqi Wang, Bolong Xu, Ruiyuan Zhu, Hengshuo Gui, Tian Xia, Shaokai Liu, Huiyu Liu, Xianwen Wang   +7 more
wiley   +1 more source

Lactate transmission from hypoxic tumor cells promotes macrophage senescence and M2 polarization via the DNMT1-NHE7 axis to accelerate endometrial cancer progression

Cell Death and Disease
Although hypoxia is a well-known key driver of metabolic reprogramming in endometrial cancer (EC), its role in lactate-mediated macrophage activation remains unclear.
Shizhou Yang, Yuejiang Ma, Tingting Wu, Xiufeng Huang   +3 more
doaj   +1 more source

Mechanisms of activation of the hypoxia-inducible transcription factor 1a

, 2002
Hypoxia Inducible Factor-1 is a heterodimeric transcription factor composed of the bHLH/PAS factors HIF-1 alpha and HIF 1 beta/ARNT. Under hypoxic conditions HIF-1 becomes activated and transcriptionally upregulates a set of target genes involved in ...
Sallyann O'Brien (7952930)
core  

Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration

BMEMat, EarlyView.
The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang, Yu‐zhu Wang, Yi‐fei Wang, Que Bai, Jia‐xin Hao, Zhi‐ting Li, Xiao‐qing Cao, Yu Wei, Yue Feng, Ji‐hua Chen, Franklin R. Tay, Rui‐bing Wang, Jun‐ting Gu, Li‐na Niu   +13 more
wiley   +1 more source

Immunohistochemical expression of hypoxia inducible factor-1 alpha (Hif -1α) in patients of head and neck squamous cell carcinoma

Journal of University Medical & Dental College
BACKGROUND & OBJECTIVE: Hypoxia-inducible factor-1 alpha (HIF-1α) could serve as a molecular target for therapy in head and neck squamous cell carcinoma (HNSCC).
Syeda Sadaf Kazmi, Rabia Anjum, Waqar Ali, Aman ur Rahman, Zia Us Salam Qazi, Saima Chaudhry   +5 more
doaj   +1 more source

Estrogen receptor 1 (ESR1) regulates VEGFA in adipose tissue

Scientific Reports, 2017
Vascular endothelial growth factor A (VEGFA) is a key factor in the regulation of angiogenesis in adipose tissue. Poor vascularization during adipose tissue proliferation causes fibrosis and local inflammation, and is associated with insulin resistance ...
L. A. Fatima, R. S. Campello, R. de Souza Santos, H. S. Freitas, A. P Frank, U. F. Machado, D. J. Clegg   +6 more
doaj   +1 more source

Living Microbial Drugs

Chemistry – A European Journal, EarlyView.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik, Nazlıcan Tunç, Senem Şen, Urartu Özgür Şafak Şeker   +3 more
wiley   +1 more source

Causal correlations between inflammatory proteins and heart failure: A two‐sample Mendelian randomization analysis

ESC Heart Failure, Volume 12, Issue 2, Page 1374-1385, April 2025.
Abstract Aims Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation‐related proteins and HF risk remains unclear.
Xian‐Guan Zhu, Gui‐Qin Liu, Ya‐Ping Peng, Li‐Ling Zhang, Xian‐Jin Wang, Liang‐Chuan Chen, Yuan‐Xi Zheng, Xue‐Jun Xiang, Rui Qiao, Xian‐He Lin   +9 more
wiley   +1 more source

Hypoxia-inducible Factor alpha Subunit Stabilization by NEDD8 Conjugation Is Reactive Oxygen Species-dependent

, 2011
Ministry of Education, Science and Technology [2009-0090188]Hypoxia-inducible factor alpha proteins (HIF-alpha s) are regulated oxygen dependently and transactivate numerous genes essential for cellular adaptation to hypoxia.
Li, Shan-Hua, 李顺华, Ryu, Ji-Hye, Park, Jong-Wan, Park, Hyoung-Sook, Lee, ByungLan, Chun, Yang-Sook   +6 more
core  

Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells

, 2002
Two human neuroblastoma (NB) cell lines, SH-SY5Y and Kelly, were found to express the gene for erythropoletin (EPO) in an oxygen (O-2)-dependent manner.
Rössler, J., Stolze, Ineke, Wotzlaw, C., Stolze, I., Freitag, Patricia, Frede, Stilla, Freitag, P., Fandrey, Joachim, Berchner-Pfannschmidt, Utta, Berchner-Pfannschmidt, U., Frede, S., Acker, H., Rössler, Jochen, Fandrey, J., Acker, Helmut, Wotzlaw, Christoph   +15 more
core   +1 more source