Results 131 to 140 of about 35,931 (278)

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

DRP1 downregulation impairs mitophagy, driving mitochondrial ROS and SASP production in rheumatoid arthritis CD4+PD-1+T cells

Redox Biology
T cell senescence occurs in patients with rheumatoid arthritis (RA), but the specific phenotype and its contribution to tissue-destructive inflammation remain unclear. Here, we aim to investigate whether PD-1 marks pathogenic senescent CD4+T cells and to
Ziran Bai, Jinyi Ren, Jiaqing Liu, Cheng Zhang, Huina Huang, Xiangge Zhao, Xianmei Chen, Jing Wei, Jingjing Qi, Siwen Yang, Weiping Li, Yawei Tang, Guan Wang, Xia Li   +13 more
doaj   +1 more source

Upregulation of miR-335 ameliorates myocardial ischemia reperfusion injury via targeting hypoxia inducible factor 1-alpha subunit inhibitor.

American journal of translational research
MicroRNA-335 (miR-335) is implicated in several pathophysiological processes, including tumorigenesis, lipid metabolism and ischemic stroke; however, whether miR-335 plays a role in modulating myocardial ischemia reperfusion injury (MIRI) is still unknown.
Nan, Wu, Xiaowen, Zhang, Shuyan, Du, Dong, Chen, Ruichao, Che   +4 more
openaire   +1 more source

Hypoxia selectively disrupts brain microvascular endothelial tight junction complexes through a hypoxia-inducible factor-1 (HIF-1) dependent mechanism

, 2014
The blood-brain barrier (BBB) constitutes a critical barrier for the maintenance of central nervous system homeostasis. Brain microvascular endothelial cells line the vessel walls and express tight junction (TJ) complexes that restrict paracellular ...
Al-Ahmad, Abraham J, Engelhardt, Sabrina, Sabrina Engelhardt, Gassmann, Max, Omolara O. Ogunshola, Ogunshola, Omolara O, Abraham J. Al‐Ahmad, Max Gassmann   +7 more
core   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Activity and mechanism of naringin in the treatment of post-infectious cough

BMC Pulmonary Medicine
Objective To explore activity and mechanism of naringin in the treatment of PIC (Post-Infectious Cough) by virtue of network pharmacology and animal studies.
Yinghan Chen, Dong Wang, Meng Song, Weiqi Pan, Wenda Guan, Zifeng Yang, Shan Zhong   +6 more
doaj   +1 more source

Hepatitis C virus-linked mitochondrial dysfunction promotes hypoxia-inducible factor 1 alpha-mediated glycolytic adaptation

, 2010
Hepatitis C virus (HCV) infection induces a state of oxidative stress by affecting mitochondrial-respiratory-chain activity. By using cell lines inducibly expressing different HCV constructs, we showed previously that viral-protein expression leads to ...
QUARATO G., GOUTTENOIRE J., SARASIN FILIPOWICZ M., CAPITANIO, NAZZARENO, PICCOLI, CLAUDIA, CELA O., SCRIMA, ROSELLA, D'APRILE A., MORADPOUR D., BOFFOLI, DOMENICO, HEIM M. H., RIPOLI M.   +11 more
core  

Unveiling the roles of extracellular vesicles in hematologic malignancies: Pathogenesis, diagnostic tools, and clinical translation

Interdisciplinary Medicine, EarlyView.
Extracellular vesicles play pivotal roles in both healthy hematopoiesis and hematologic malignancies. They not only regulate hematopoietic stem cell fitness but also drive cancer progression and drug resistance. Their clinical potential spans from serving as non‐invasive biomarkers to acting as innovative therapeutic platforms and drug delivery ...
Fengyu Chen, Zhiyuan Wu, Feng Zhang, Yuan Meng, Hongyan Liao, Tony Y. Hu   +5 more
wiley   +1 more source

Arsenite stabilizes HIF-1 alpha protein through p85 alpha-mediated up-regulation of inducible Hsp70 protein expression

, 2011
Hypoxia-inducible factor-1 alpha (HIF-1 alpha) has been reported to regulate over 100 gene expressions in response to hypoxia and other stress conditions.
Yang, Zhuo, Li, Jingxia, Yu, Yonghui, Zhang, Dongyun, Huang, Chuanshu, Guo, Wei, Zuo, Zhenghong, Li, Xueyong, Xia, Qing, Liu, Jinyi, Shi, Xianglin, 左正宏   +11 more
core  

Regulation of the Drosophila bHLH-PAS protein Sima by hypoxia: functional evidence for homology with mammalian HIF-1 alpha.

, 1998
Hypoxia inducible factor-1 (HIF-1) is a heterodimeric complex of two basic-helix-loop-helix proteins of the PAS family which is critical for oxygen-dependent expression of many mammalian genes.
Bacon, NC, Bartlett, SM, Wappner, P, Ratcliffe, Peter, O'Rourke, JF, Shilo, B, Pugh, Christopher   +6 more
core   +1 more source