Results 81 to 90 of about 35,931 (278)

Cigarette Smoke‐Induced Alveolar Macrophage Senescence via GEM/SIRT3‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
Cigarette smoke accelerates the aging of immune cells in the lung. By combining human single‐cell sequencing, cell culture, and mouse models, the authors show that the protein GEM drives mitochondrial damage and senescence in alveolar macrophages by suppressing SIRT3.
Jin Wang, Meidan Wei, Xiangrong Song, Jiaxin Zhang, Lisha Zhang, Sixian Chen, Yaoyu Hu, Hui Gao, Jianxiang Li   +8 more
wiley   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Digoxin attenuates LPS-induced acute lung injury in mice via NF-κB and HIF-1α inhibition

Biomolecules & Biomedicine
Acute lung injury (ALI), which can progress to the highly lethal acute respiratory distress syndrome (ARDS), remains a condition with limited pharmacological interventions, highlighting the urgent need for mechanism-informed repurposing strategies ...
Abdulaziz M. Alzahrani, Mai A. Alim A. Sattar Ahmad, Wafaa S. Ramadan, Huda M. Alkreathy   +3 more
doaj   +1 more source

Microarray analysis of pathways involved in bladder cancer invasion and metastasis.

, 2008
MDHypoxia-inducible genes have been linked to the aggressive phenotype of cancer. However, nearly all work on hypoxia-regulated genes has been conducted in vitro on cell lines.
Ord, Jonathan J
core  

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source

Hypoxia Inducible Factor-1 Alpha as a Diagnostic Marker in Early Diabetic Nephropathy

Biomedical and Biotechnology Research Journal
Background: Research on the diagnostic utility of hypoxia-inducible factor-1 alpha (HIF-1α) as an indicator of diabetic kidney disease (DKD) in the Indian population is lacking.
Shriya Narendra Shet Shirodkar, Sindhu, Poornima Ajay Manjrekar, Neelam M Pawar, Sowndarya Kollampare, Janice Dsa   +5 more
doaj   +1 more source

Mechanisms Of Hypoxia-Induced Immune Escape In Cancer And Their Regulation By Nitric Oxide

Redox Biology, 2015
The acquired ability of tumour cells to avoid destruction by immune effector mechanisms (immune escape) is important for malignant progression. Also associated with malignant progression is tumour hypoxia, which induces aggressive phenotypes such as ...
Charles Graham, Ivraym Barsoum, Judy Kim, Madison Black, Robert D. Siemens   +4 more
doaj   +1 more source

Regulation of the hypoxia-inducible factor-1 alpha. ARNT is not necessary for hypoxic induction of HIF-1 alpha in the nucleus

, 2002
Hypoxia-inducible factor-1 (HIF-1) is a master regulator of mammalian oxygen homeostasis. HIF-1 consists of two subunits, HIF-1 alpha and the aryl hydrocarbon receptor nuclear translocator (ARNT).
Gassmann, Max; https://orcid.org/, Dmitri Chilov, Roland H. Wenger, Max Gassmann, Chilov, D, Wenger, R H   +5 more
core   +1 more source

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. [PDF]

, 1998
Hypoxia is an essential developmental and physiological stimulus that plays a key role in the pathophysiology of cancer, heart attack, stroke, and other major causes of mortality.
Leung, S W, Lawler, A M, Yu, A Y, Semenza, G L, Iyer, N V, Gearhart, J D, Kotch, L E, Agani, F, Laughner, E, Wenger, R H, Gassmann, M   +10 more
core   +1 more source

Advances in Cancer Immunotherapy for Solid Tumors

Advanced Science, EarlyView.
Cancer immunotherapy for solid tumors is rapidly evolving beyond classical checkpoint blockade toward more precise strategies. Emerging checkpoint targets, bispecific antibodies, antibody–drug conjugate combinations, personalized vaccines, cellular therapies, and engineered cytokines are expanding therapeutic possibilities, while biomarker‐guided ...
Shira Gabizon‐Peretz, Harriet M. Kluger   +1 more
wiley   +1 more source