Results 81 to 90 of about 65,547 (283)

Caffeine affects the biological responses of human hematopoietic cells of myeloid lineage via downregulation of the mTOR pathway and xanthine oxidase activity [PDF]

, 2015
Correction of human myeloid cell function is crucial for the prevention of inflammatory and allergic reactions as well as leukaemia progression. Caffeine, a naturally occurring food component, is known to display anti-inflammatory effects which have ...
Abooali, Maryam, Berger, Steffen M., Casely-Hayford, Maxwell A., Fasler-Kan, Elizaveta, Gibbs, Bernhard F., Gonçalves Silva, Isabel, Prokhorov, Alexandr, Sumbayev, Vadim V., Yasinska, Inna M.   +8 more
core   +3 more sources

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Hypoxia‐induced HIF‐1α and ZEB1 are critical for the malignant transformation of ameloblastoma via TGF‐β‐dependent EMT

Cancer Medicine, 2019
Ameloblastic carcinoma (AC) is defined as a rare primary epithelial odontogenic malignant neoplasm and the malignant counterpart of benign epithelial odontogenic tumor of ameloblastoma (AB) by the WHO classification.
Shohei Yoshimoto, Fumie Tanaka, Hiromitsu Morita, Akimitsu Hiraki, Shuichi Hashimoto   +4 more
doaj   +1 more source

Expression pattern of HIF1α mRNA in brain, heart and liver tissues of Tibet chicken embryos in hypoxia revealed with quantitative real-time PCR

Animal, 2007
The problem of hypoxia adaptation in high altitudes is an unsolved brainteaser in the field of the life sciences. As one of the best chicken breeds with adaptability to highland environment, the Tibet chicken, is genetically different from lowland ...
L.F. Zhang, L.S. Lian, C.J. Zhao, J.Y. Li, H.G. Bao, Ch. Wu   +5 more
doaj   +1 more source

Assessment of HIF-1α expression and release following endothelial injury in-vitro and in-vivo [PDF]

, 2018
Background: Endothelial injury is an early and enduring feature of cardiovascular disease. Inflammation and hypoxia may be responsible for this, and are often associated with the up-regulation of several transcriptional factors that include Hypoxia ...
A Gorlach, A Lidgren, A Loboda, C Kilkenny, CM Lambert, D Tekin, DA Tulis, E Karshovska, GAA Ferns, GL Semenza, Gordon Ferns, HX Chu, HZ Imtiyaz, J Fingerle, J He, JL Formento, L Bautista, L Heikal, Lamia Heikal, LG Gao, M Kobayashi, M Xu, Manuela Mengozzi, MS Al Okail, Pietro Ghezzi, QD Ke, R Natarajan, RA Mosher, S Srinivasan, S Zhang, S-G Ong, SL Song, SR Park, TD Eubank, TD Eubank, TE Walshe, WL Li   +36 more
core   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Multi-TGDR: a regularization method for multi-class classification in microarray experiments [PDF]

, 2013
Background With microarray technology becoming mature and popular, the selection and use of a small number of relevant genes for accurate classification of samples is a hot topic in the circles of biostatistics and bioinformatics.
Suárez-Fariñas, Mayte, Tian, Suyan
core   +3 more sources

Tailored Porous Bimetallic Nanozyme Platform for Full‐Cycle Therapeutics of Intestinal Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Intestinal ischemia/reperfusion (I/R) injury presents a biphasic pathology: an acute oxidative‐inflammatory phase leading to organ failure, and a recovery phase marked by mucosal dysfunction and bacterial translocation. The developed MPB@TA‐Cu‐Ma nanocomposite functions as a dual‐phase therapeutic platform with significant efficacy. It rapidly
Chenghao Qiu, Wenjing Xian, Mengxue Wang, Guozhi Zhao, Yanhuo Zhang, Zhiyu Zhou, Bo Sheng, Zhuo Zhen, Xie Liu, Shouwen Diao, Mengwei Tu, Chen Qiu, Huixian Wang, Jianbo Zhang, Peng Zhu, Tong Li   +15 more
wiley   +1 more source

Neutrophil‐Driven Cascade‐Targeted Nanocarriers Restore Mitochondrial Homeostasis to Ameliorate Renal Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A neutrophil‐mediated dual‐targeting liposome (NKN‐LNP) is developed to treat renal ischemia–reperfusion injury. The system enables spatiotemporally controlled delivery of NMN to injured tubules via MMP‐2/9 activation and KIM1 recognition, restoring mitochondrial function through NAD+‐SIRT3 signaling and preventing the transition from acute kidney ...
Hangbin Ma, Yang Li, Shen Lin, Feifan Chu, Gaozhan Ren, Yinhui Mao, Mingzhi Wu, Yuning Ma, Qiwei Ji, Zujie Chen, Jinzhong Ji, Mingxin Sun, Yongpeng Xu, Xiaoli Sun, Longguang Tang, Hao Zhou   +15 more
wiley   +1 more source

Endurance training increases tmTNF-α and IL-6 levels in several vital organs in rats: relationship with hypoxia markers

Frontiers in Molecular Biosciences
BackgroundAlthough endurance training is known to induce systemic adaptations involving inflammatory and hypoxia-related signaling, tissue-specific protein responses remain incompletely understood.
Lukasz Galganski, Jerzy A. Zoladz, Wieslawa Jarmuszkiewicz   +2 more
doaj   +1 more source