Results 111 to 120 of about 229,207 (357)

The Role of Hypoxia Inducible Factor-1 in Hepatocellular Carcinoma

BioMed Research International, 2014
Hypoxia is a common feature of many solid tumors, including hepatocellular carcinoma (HCC). Hypoxia can promote tumor progression and induce radiation and chemotherapy resistance. As one of the major mediators of hypoxic response, hypoxia inducible factor-1 (HIF-1) has been shown to activate hypoxia-responsive genes, which are involved in multiple ...
Dongjun Luo, Zhongxia Wang, Junyi Wu, Chunping Jiang, Junhua Wu   +4 more
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Hypoxia-inducible factor 1α inhibitor reduces hippocampal neuronal ferroptosis

Neural Regeneration Research
Epilepsy is a prevalent neurological disorder in which hippocampal neuronal damage, particularly ferroptosis, plays a critical role. Previous studies have shown that hypoxia-inducible factor 1α is considered an important regulator of cellular stress ...
Zhen Liang, Qi Guo, Zhaoshi Zheng, Yingyue Lou, Xiaojuan Zhu, Songyan Liu   +5 more
doaj   +1 more source

Improved nuclear localization of DNA-binding polyamides [PDF]

, 2006
Regulation of endogenous genes by DNA-binding polyamides requires effective nuclear localization. Previous work employing confocal microscopy to study uptake of fluorophore-labeled polyamides has demonstrated the difficulty of predicting a priori the ...
Baird, Belitsky, Belitsky, Best, Bianchi, Claire S. Jacobs, Crowley, Dervan, Dervan, Dervan, Dickinson, Dudouet, Edelson, Foister, Gottesfeld, Juliano, Kaizerman, Kielkopf, Kong, Michelle E. Farkas, Nguyen-Hackley, Nicholas G. Nickols, Olenyuk, Peter B. Dervan, Suto, Trauger, Ueda, Vandyke, White, Wood, Wurtz   +30 more
core   +3 more sources

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Hypoxia-Inducible Factor 1 Protects Hypoxic Astrocytes against Glutamate Toxicity

ASN Neuro, 2012
Stroke is a major neurological disorder characterized by an increase in the Glu (glutamate) concentration resulting in excitotoxicity and eventually cellular damage and death in the brain. HIF-1 (hypoxia-inducible factor-1), a transcription factor, plays
Yomna Badawi, Prabhu Ramamoorthy, glian Shi   +2 more
doaj   +1 more source

Oxygen – the forgotten nutrient

Journal of Nutritional Science, 2017
O2 is essential for the maintenance and growth of aerobic animals, similar to the essentiality of what are classically considered nutrients. Nevertheless, O2 is not customarily regarded as a nutrient, this reflecting the route by which it enters the body
Paul Trayhurn
doaj   +1 more source

The zebrafish xenograft platform-A novel tool for modeling KSHV-associated diseases [PDF]

, 2019
Kaposi\u27s sarcoma associated-herpesvirus (KSHV, also known as human herpesvirus-8) is a gammaherpesvirus that establishes life-long infection in human B lymphocytes.
Berman, Jason N, Coombs, Andrew J, Dellaire, Graham, Druley, Todd E, Ha, Michael N, McCormick, Craig, Melong, Nicole, O\u27Leary, David, Pringle, Eric S, Robinson, Carolyn-Ann, Veinotte, Chansey, Wertman, Jaime, Young, Andrew L   +12 more
core   +2 more sources

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

In Vitro Investigation of HIF-1α as a Therapeutic Target for Thyroid-Associated Ophthalmopathy [PDF]

Endocrinology and Metabolism
Background Thyroid-associated ophthalmopathy (TAO) involves tissue expansion and inflammation, potentially causing a hypoxic microenvironment. Hypoxia-inducible factor (HIF)-1α is crucial in fibrosis and adipogenesis, which are observed in TAO ...
Jeongmin Lee, Jinsoo Lee, Hansang Baek, Dong-Jun Lim, Seong-Beom Lee, Jung-Min Lee, Sang-Ah Jang, Moo Il Kang, Suk-Woo Yang, Min-Hee Kim   +9 more
doaj   +1 more source