Results 301 to 310 of about 229,207 (357)

POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation

Advanced Science, EarlyView.
Schematic diagram of our study showing that highly expressed POU2F1 in colorectal cancer (CRC) can directly accelerate the cytosolic lactate export to decrease PPP1R11 lactylation at K59, thereby attenuating the E3 ligase enzyme activity and protein stability of PPP1R11, which inhibits the ubiquitination of MDR2 at K413 and K538 but increases the ...
Longzheng Xia, Jinguan Lin, Xianjie Jiang, Linda Oyang, Shiming Tan, Zongyao Ren, Qiu Peng, Qianjin Liao, Yujuan Zhou   +8 more
wiley   +1 more source

Cannabidiol effectively prevents oxidative stress and stabilizes hypoxia-inducible factor-1 alpha (HIF-1α) in an animal model of global hypoxia. [PDF]

Sci Rep
Kletkiewicz H, Wojciechowski MS, Rogalska J.   +2 more
europepmc   +1 more source

Investigating the relationship between hypoxia, hypoxia-inducible factor 1, and the optical redox ratio in response to radiation therapy. [PDF]

Biophotonics Discov
Ivers JD, Puvvada N, Quick CM, Rajaram N.   +3 more
europepmc   +1 more source

3-Hydroxytanshinone Inhibits the Activity of Hypoxia-Inducible Factor 1-α by Interfering with the Function of α-Enolase in the Glycolytic Pathway. [PDF]

Molecules
Son TH, Kim SH, Shin HL, Kim D, Kim HG, Choi Y, Choi SW.   +6 more
europepmc   +1 more source

The Role of MicroRNA-206 in the Regulation of Diabetic Wound Healing via Hypoxia-Inducible Factor 1-Alpha. [PDF]

Biochem Genet
Bai Z, Zhou D, Tao K, Lin F, Wang H, Sun H, Liu R, Li Z.   +7 more
europepmc   +1 more source

Targeting Hypoxia-Inducible Factor-1 (HIF-1) in Cancer: Emerging Therapeutic Strategies and Pathway Regulation. [PDF]

Pharmaceuticals (Basel)
Qannita RA, Alalami AI, Harb AA, Aleidi SM, Taneera J, Abu-Gharbieh E, El-Huneidi W, Saleh MA, Alzoubi KH, Semreen MH, Hudaib M, Bustanji Y.   +11 more
europepmc   +1 more source

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Hypoxia-Inducible Factor-1 (HIF-1)

Molecular Pharmacology, 2006
Adaptation to low oxygen tension (hypoxia) in cells and tissues leads to the transcriptional induction of a series of genes that participate in angiogenesis, iron metabolism, glucose metabolism, and cell proliferation/survival. The primary factor mediating this response is the hypoxia-inducible factor-1 (HIF-1), an oxygen-sensitive transcriptional ...
Qingdong, Ke, Max, Costa
openaire   +2 more sources

Hypoxia Induces Transcription Factor ETS-1 via the Activity of Hypoxia-Inducible Factor-1

Biochemical and Biophysical Research Communications, 2001
ETS-1 plays an important role in angiogenesis and cancer invasion, and hypoxia is a common feature in these phenomena. We examined whether hypoxia influenced ETS-1 expression. Hypoxia induced ETS-1 in a human bladder cancer cell line, T24, and promoter analysis revealed that the deletion of -424 to -279 bp from the human ETS-1 promoter decreased the ...
M, Oikawa, M, Abe, H, Kurosawa, W, Hida, K, Shirato, Y, Sato   +5 more
openaire   +2 more sources