Results 311 to 320 of about 229,207 (357)
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Hypoxia‐inducible factor‐1 and oncogenic signalling
BioEssays, 2004AbstractAn understanding of underlying mechanisms involved in the activation of HIF‐1 in response to both hypoxic stress and oncogenic signals has important implications for how these processes may become deregulated in human cancer. Changes in microenvironmental stimuli such as hypoxia and growth factors in combination with genetic lesions, such as ...
Bardos, JI, Athcroft, M
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Hypoxia-inducible factor 1 in autoimmune diseases
Cellular Immunology, 2016Autoimmune disorders are a complicated and varied group of diseases arising from inappropriate immune responses. Recent studies have demonstrated that ongoing inflammatory and immune responses are associated with increased oxygen consumption, a process resulting in localized tissue hypoxia within inflammatory lesions ("inflammatory hypoxia"), in which ...
Wei, Deng +4 more
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Hypoxia Induced Infertility in Males: Role of Transcription Factor Hypoxia Inducible Factor -1 Alpha
Pakistan Journal of Medical and Health Sciences, 2022Aim: To assess concentrations of HIF-1 α and correlation between HIF-1 α in healthy and sub fertile males’ population in our study. Methodology: In this study we investigated the concentrations of Hypoxia Inducible Factor 1-α (pg/mL) in the seminal plasma of healthy fertile males and sub fertile males using Enzyme-Linked ImmunoSorbent Assay (ELISA ...
Aasma Zaidi +5 more
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Hypoxia-Inducible Factor 1 and Preeclampsia: A New Perspective
Current Hypertension Reports, 2022Preeclampsia (PE) is a serious and distinct type of pregnancy-induced hypertension, with an incidence of 2-8% worldwide. PE is defined as pregnancy-related hypertension with proteinuria and peripheral edema after 20 weeks of gestation. Hypoxic placenta triggers the release of inflammatory and humoral substances into maternal circulation, leading to ...
Albogami, Sarah +10 more
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Hypoxia‐Inducible Factor 1 Inhibitors
2007The tremendous progress in our understanding of the molecular mechanisms underlying the presence and consequences of hypoxia in human cancers has been accompanied by renewed enthusiasm for the development of therapeutic strategies targeting hypoxic cells signaling pathways.
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Regulation of angiogenesis by hypoxia-inducible factor 1
Critical Reviews in Oncology/Hematology, 2006Hypoxia is an imbalance between oxygen supply and demand that occurs in cancer and in ischemic cardiovascular disease. Hypoxia-inducible factor 1 (HIF-1) was originally identified as the transcription factor that mediates hypoxia-induced erythropoietin expression.
Kiichi, Hirota, Gregg L, Semenza
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Hypoxia-inducible factor 1 (HIF-1) in cancer
European Journal of Surgical Oncology (EJSO), 2004Hypoxia is a common feature of many cancers. It contributes to local and systemic tumour progression as well as potentially compromising radiotherapy and chemotherapy. Hypoxia-inducible factor 1 (HIF-1) is an essential component in changing the transcriptional response of tumours under hypoxia.
M, Quintero, N, Mackenzie, P A, Brennan
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Signal transduction to hypoxia-inducible factor 1
Biochemical Pharmacology, 2002Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that functions as a master regulator of O2 homeostasis. HIF-1 target genes encode proteins that increase O2 delivery and mediate adaptive responses to O2 deprivation. HIF-1 activity is regulated by the cellular O2 concentration and by the major growth factor-stimulated signal ...
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Hypoxia-Inducible Factors and Sphingosine 1-Phosphate Signaling
Anti-Cancer Agents in Medicinal Chemistry, 2011Hypoxia, defined as reduced tissue oxygen concentration, is a characteristic of solid tumors and is an indicator of unfavorable diagnosis in patients. At the cellular level, the adaptation to hypoxia is under the control of two related transcription factors, HIF-1α and HIF-2α (Hypoxia-Inducible Factor), which activate expression of genes promoting ...
Olivier, Cuvillier, Isabelle, Ader
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Regulation of Vascularization by Hypoxia‐Inducible Factor 1
Annals of the New York Academy of Sciences, 2009Vascularization and vascular remodeling represent critical adaptive responses to tissue hypoxia that are mediated by hypoxia‐inducible factor 1 (HIF‐1). In patients with peripheral arterial disease, these responses are impaired by aging and diabetes, leading to critical limb ischemia and amputation.
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