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Hypoxia-Inducible Factor 1 in Lower Limb Ischemia
Vascular, 2006In the Western world, peripheral vascular disease (PVD) has a high prevalence and is associated with high morbidity and mortality. More patients are presenting with critical limb ischemia (CLI), the end stage of PVD, because of an increased life expectancy owing to improved medical care.
Teik K, Ho +3 more
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Hypoxia-Inducible Factor 1 (HIF-1) Pathway
Science's STKE, 2007Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix-PAS domain transcription factor that is expressed in all metazoan organisms and is composed of HIF-1α and HIF-1β subunits. Under hypoxic conditions, HIF-1 regulates the transcription of hundreds of genes in a cell type–specific manner. The HIF-1α subunit is regulated by O
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Hypoxia-inducible-factor-1 in trauma and critical care
Journal of Critical Care, 2017HIF-1 is a ubiquitous signaling molecule constantly expressed by the body, but is degraded during normoxic conditions. In hypoxic conditions, it persists and is active. Hypoxia is often associated with trauma due to interrupted blood flow, inflammation or other reasons, causing HIF-1 to be active in signaling and recovery.
Bogdanovski, Dorian A. +8 more
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HIF‐1: hypoxia‐inducible factor or dysoxia‐inducible factor?
The FASEB Journal, 2006Hypoxia‐inducible factor 1 (HIF‐1) activates the transcription of genes involved in diverse aspects of cellular and integrative physiology, including energy metabolism, cell growth, survival, invasion, migration or angiogenesis. The activity of this transcription factor is known to be increased by hypoxia, but also by a growing ...
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Oxygen(es) and the hypoxia-inducible factor-1.
Biological chemistry, 1997The hypoxia-inducible factor-1 (HIF-1) is a basic-helix-loop-helix (bHLH) heterodimeric transcription factor activated by reductions in oxygen concentration (hypoxia). Activated HIF-1 upregulates expression of genes involved in the adaptation of higher organisms to hypoxic conditions, caused by e.g.
Wenger, R H, Gassmann, M
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Role of hypoxia-inducible factor 1 in type 1 diabetes
Trends in Pharmacological SciencesType 1 diabetes (T1D) is a common autoimmune disease in which dysregulated glucose metabolism is a key feature. T1D is both poorly understood and in need of improved therapeutics. Hypoxia is frequently encountered in multiple tissues in T1D patients including the pancreas and sites of diabetic complications.
Raphael R. Fagundes +2 more
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Involvement of Hypoxia-Inducible Factor 1 in Pulmonary Pathophysiology
Chest, 2005Hypoxia-inducible factor (HIF)-1 is a transcription factor that is activated in response to hypoxia and growth factor/cytokine signaling via regulation of the HIF-1alpha subunit. HIF-1 has been implicated in the pathogenesis of pulmonary hypertension based on both experimental and clinical data.
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Hypoxia-Inducible Factor 2 Alpha (HIF2α) Inhibitors: Targeting Genetically Driven Tumor Hypoxia
Endocrine Reviews, 2023Camilo Jimenez +2 more
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