Results 131 to 140 of about 1,301,346 (361)

Hypoxia-Inducible Factors (HIFs) and Phosphorylation: Impact on Stability, Localization, and Transactivity

Front. Cell Dev. Biol., 2016
The hypoxia-inducible factor α-subunits (HIFα) are key transcription factors in the mammalian response to oxygen deficiency. The HIFα regulation in response to hypoxia occurs primarily on the level of protein stability due to posttranslational ...
T. Kietzmann, Daniela Mennerich, E. Dimova   +2 more
semanticscholar   +1 more source

Targeting hypoxia-inducible factor-1α (HIF-1α) in combination with antiangiogenic therapy: a phase I trial of bortezomib plus bevacizumab. [PDF]

, 2014
PurposeWe hypothesized that bortezomib, an agent that suppresses HIF-1α transcriptional activity, when combined with bevacizumab, would obviate the HIF-1α resistance pathway.
Amin, Hesham M, Angelo, Laura S, Falchook, Gerald S, Hess, Kenneth, Hong, David, Howard, Adrienne N, Huang, Mei, Jackson, Edward F, Janku, Filip, Kurzrock, Razelle, Lawhorn, Kristie N, Naing, Aung, Ng, Chaan S, Parkhurst, Kristin L, Tannir, Nizar M, Vishwamitra, Deeksha, Wheler, Jennifer J   +16 more
core   +2 more sources

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Hypoxia in Alzheimer's disease: effects of hypoxia inducible factors

Neural Regeneration Research, 2021
Halimatu Hassan, Ruoli Chen
doaj   +1 more source

Endothelins and hypoxia-inducible factor in cancer [PDF]

Endocrine-Related Cancer, 2007
The endothelin system is a family of three similar small peptides, two G-protein-coupled receptors and two proteinases. Endothelins have several physiological roles, notably in embryonic differentiation and vascular homeostasis. Numerous types of tumour express endothelins and their regulation is often aberrant when compared with the normal tissue from
openaire   +3 more sources

Mouse models for preeclampsia: disruption of redox-regulated signaling [PDF]

, 2009
The concept that oxidative stress contributes to the development of human preeclampsia has never been tested in genetically-defined animal models. Homozygous deletion of catechol-Omethyl transferase (Comt-/-) in pregnant mice leads to human preeclampsia ...
A Malassine, AC Epstein, AM Carter, AM Zafari, Anne E Chambers, AP MacKay, BJ Hawkins, C Moser, C Peyssonnaux, CW Redman, D Berg, D Gerald, DS Hoffmann, DS Tannetta, EL Bell, EL Pagé, FX Yi, GL Semenza, H Pelicano, Harpal Randeva, I Thaler, J Golab, J Sugawara, JA Martin, K Kanasaki, L Duley, L Wood, M Geiszt, M Ushio-Fukai, M Wang, N Kanayama, NS Chandel, P Huang, PH Maxwell, R Dworakowski, R Pijnenborg, RD Martin, RK Bruick, RW Redline, S Banerjee, S Lamond, S Melov, S Muzaffar, S Nemoto, SL Adamson, Subhasis Banerjee, T Cramer, T Torbergsen, Y Liu, Y Pan, Y Wang, YA Suh   +51 more
core   +4 more sources

Hyperoxia Induced Alteration of Chromatin Structure in Human Bone Marrow Derived Primary Mesenchymal Stromal Cells

Advanced Biology, EarlyView.
Chromatin, which organizes DNA, changes its structure to adapt to stress like high oxygen levels (hyperoxia), which can damage cells. Researchers developed a technique to observe these changes and found variability in how different parts of chromatin remodel.
Lauren Monroe, Samantha Kaonis, Natalie Calahan, Neda Kabi, Soham Ghosh   +4 more
wiley   +1 more source

Regulation of cell proliferation by hypoxia-inducible factors.

American Journal of Physiology - Cell Physiology, 2015
Hypoxia is a physiological cue that impacts diverse physiological processes, including energy metabolism, autophagy, cell motility, angiogenesis, and erythropoiesis.
Maimon E Hubbi, G. Semenza
semanticscholar   +1 more source

Activation of SIRT1 Reduces Renal Tubular Epithelial Cells Fibrosis in Hypoxia Through SIRT1‐FoxO1‐FoxO3‐Autophagy Pathway

Advanced Biology, EarlyView.
Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang, Lijuan Zhang, Jiaorong Tan, Fei Li, Yishan Jin, Limei He, Xin Yang   +6 more
wiley   +1 more source

Glioblastoma multiforme: Effect of hypoxia and hypoxia inducible factors on therapeutic approaches

Oncology Letters, 2016
Central nervous system-based cancers have a much higher mortality rate with the 2016 estimates at 6.4 for incidence and 4.3 for deaths per 100,000 individuals.
Wenjuan Huang, Wei-Wei Chen, Xia Zhang
semanticscholar   +1 more source