Results 291 to 300 of about 1,301,346 (361)

Engineered Foxp1high Exosomes Ameliorates Systemic Lupus Erythematosus

Advanced Science, EarlyView.
This study presents a dual‐engineering strategy combining mesenchymal stem cell aggregation and Foxp1 overexpression to generate Foxp1high aggregation exosomes with enhanced immunomodulatory properties. These engineered exosomes exhibit immune organ targeting and superior efficacy in systemic lupus erythematosus treatment by promoting Treg ...
Luhan Niu, Qianmin Ou, Qianhui Ren, Zhengshi Li, Hongcheng Chen, Fangcao Lei, Xueli Mao, Songtao Shi, Zetao Chen, Wei Teng   +9 more
wiley   +1 more source

Time, location and function of hypoxia-inducible factors are critical to therapeutic tumour response. [PDF]

BMJ Oncol
Marignol L, Pugh CW.
europepmc   +1 more source

Spontaneous spheroids from alveolar bone-derived mesenchymal stromal cells maintain pluripotency of stem cells by regulating hypoxia-inducible factors. [PDF]

Biol Res, 2023
Li N, Dai X, Yang F, Sun Y, Wu X, Zhou Q, Chen K, Sun J, Bi W, Shi L, Yu Y.   +10 more
europepmc   +1 more source

The p14ARF Tumor Suppressor Protein Facilitates Nucleolar Sequestration of Hypoxia-inducible Factor-1α (HIF-1α) and Inhibits HIF-1-mediated Transcription [PDF]

, 2001
Károly Fátyol, Aladar A. Szalay
openalex   +1 more source

Ultrasound‐Induced Nitric Oxide‐Propelled Nanomotor for Multimodal Theranostics of Cancer with Deep Penetration and Extended Lifetime

Advanced Science, EarlyView.
A hollow nanomotor (PM‐HMSN/Arg) propelled by ultrasound‐triggered nitric oxide (NO) was developed. The nanomotor employs a “tethering‐relaxing‐drilling” mechanism to overcome biological barriers, enabling multimodal theranostics of cancer with deep penetration and extended lifetime.
Xue Xu, Jinxu Cao, Yan Mu, Hao Zhang, Ya‐Lei Wang, Mengzhen Chen, Yuce Li, Qian Hua   +7 more
wiley   +1 more source

Revisiting the role of hypoxia-inducible factors and nuclear factor erythroid 2-related factor 2 in regulating macrophage inflammation and metabolism. [PDF]

Front Cell Infect Microbiol
Ting KKY.
europepmc   +1 more source

Differential Regulation of Two Alternatively Spliced Isoforms of Hypoxia-inducible Factor-1α in Activated T Lymphocytes [PDF]

, 2001
Dmitriy Lukashev, Charles C. Caldwell, Akio Ohta, Pearl Chen, Michail V. Sitkovsky   +4 more
openalex   +1 more source

Prevalence of FoxP3+ Cells in Canine Tumours and Lymph Nodes Correlates Positively with Glucose Transporter 1 Expression [PDF]

, 2016
A. Hibbert, Abbondati, Airley, Ben-Shoshan, Brizel, Brown, Brown, Brusko, Bussink, Campbell, Ciaraldi, Clambey, Clarke, Coffer, Comerford, Deng, Deng, Duechler, Eltzschig, Facciabene, Falanga, Fenton, Freyer, Fu, Grau, Gray, H.M. Martineau, Haber, Haney, Hansen, Höckel, Höckel, Imtiyaz, Ishida, J. Relf, Josefowicz, Kallio, Kim, Kinoshita, Koch, Konerding, L. Fortuna, Liyanage, Luoto, Mantovani, Medina, Neildez-Nguyen, Nishikawa, Noman, O.A. Garden, Oh, Ozgur, Pennacchietti, Petty, Pinheiro, Rudlowski, Sakoda, Scholz, Secomb, Skinner, Snyder, Thornton, Vaupel, Wang, Wang, Y.-M. Chang, Yan, Younes   +67 more
core   +2 more sources

Metabolic Stress‐Induced Choline Kinase α (CHKA) Activation in Endothelial Subpopulation Contributes to Diabetes‐Associated Microvascular Dysfunction

Advanced Science, EarlyView.
This study uncovers CHKA as a pivotal driver of vascular dysfunction in diabetic retinopathy and highlights its role in endothelial dysfunction through NAD⁺‐SIRT1‐Notch signaling. Single‐cell and functional analyses, combined with clinical and genetic validation, suggest CHKA as a promising therapeutic target for the prevention and treatment of ...
Ling Ren, Linyu Zhang, Yun Bai, Chang Huang, Xiaosa Li, Fanfei Ma, Wan Mu, Mudi Yao, Chang Jiang, Xiangjun Chen, Qin Jiang, Biao Yan   +11 more
wiley   +1 more source

Marine-Derived Leads as Anticancer Candidates by Disrupting Hypoxic Signaling through Hypoxia-Inducible Factors Inhibition. [PDF]

Mar Drugs
Garcia MR, Andrade PB, Lefranc F, Gomes NGM.   +3 more
europepmc   +1 more source