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Advanced Science, EarlyView.EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).
Zilong Chen +9 more
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Intratumoral Hypoxia and Mechanisms of Immune Evasion Mediated by Hypoxia-Inducible Factors.
Physiology, 2021Activation of the innate and adaptive immune systems represents a promising strategy for defeating cancer. However, during tumor progression, cancer cells battle to shift the balance from immune activation to immunosuppression.
G. Semenza
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Hypoxia-inducible factors and cancer
Clinical and Translational Oncology, 2007Decreased oxygen availability is a common feature during embryonic development as well of malignant tumours. Hypoxia regulates many transcription factors, and one of the most studied is the hypoxia-inducible factor (HIF). As a consequence of HIF stabilisation, the cell constitutively upregulates the hypoxic programme resulting in the expression of ...
L. del Peso, Maria J. Calzada
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Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology.
Annual Review of Pathology, 2014Hypoxia-inducible factors (HIFs) are transcriptional activators that function as master regulators of oxygen homeostasis, which is disrupted in disorders affecting the circulatory system and in cancer.
G. Semenza
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Hypoxia-inducible factor in brain
2001HIF-1 is composed of HIF-1alpha and HIF-1beta protein subunits. HIF-1 is induced by hypoxia and binds to promoter/enhancer elements and stimulates the transcription of hypoxia-inducible target genes. Because HIF-1 activation might promote cell survival in hypoxic tissues, we studied the effect of stroke on the expression of HIF-1alpha, HIF-1beta and ...
Frank R. Sharp +2 more
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Redox regulation of the hypoxia-inducible factor
Biological Chemistry, 2006Reactive oxygen species (ROS) have long been considered only as cyto- and genotoxic. However, there is now compelling evidence that ROS also act as second messengers in response to various stimuli, such as growth factors, hormones and cytokines. The hypoxia-inducible transcription factor (HIF) is a master regulator of oxygen-sensitive gene expression ...
Fatima Mechta-Grigoriou +1 more
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Structural integration in hypoxia-inducible factors
Nature, 2015The hypoxia-inducible factors (HIFs) coordinate cellular adaptations to low oxygen stress by regulating transcriptional programs in erythropoiesis, angiogenesis and metabolism. These programs promote the growth and progression of many tumours, making HIFs attractive anticancer targets.
Dalei Wu +4 more
semanticscholar +4 more sources
Mitochondria and Hypoxia‐induced Gene Expression Mediated by Hypoxia‐inducible Factors
Annals of the New York Academy of Sciences, 2008The influence of mitochondrial activity on gene expression programs, particularly those involved in neuroprotection and repair, is likely to play an important role in the pathophysiology of neurodegenerative diseases. One such gene expression program is activated by the cellular pathway that senses a decrease in optimal oxygen levels and leads to ...
Juan C. Chavez +3 more
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Hypoxia-induced radioresistance is independent of hypoxia-inducible factor-1A in vitro
International Journal of Radiation Oncology*Biology*Physics, 2005We sought to determine whether hypoxia-induced radioresistance is mediated by the transcription factor hypoxia-inducible factor-1alpha (HIF-1alpha).We used 2 mouse embryonic fibroblast cell lines transformed with H-ras and TAg, 1 HIF-1alpha+/+ and the other HIF-1alpha-/-.
Dennis F. Deen +6 more
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The role of hypoxia-inducible factors in cancer
Cellular and Molecular Life Sciences, 2007Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor that mediates the adaptive responses to hypoxia by effecting the transcription of numerous hypoxia-inducible genes. HIF is frequently overexpressed in solid tumors, and the transactivation of HIF targets in transformed cells provides a distinct survival advantage.
M. A. Maynard, M. Ohh
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