Results 341 to 350 of about 1,301,346 (361)

EBBP‐Mediated Integrated Stress Response Attenuates Anthracycline‐Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes

open access: yesAdvanced Science, EarlyView.
EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).
Zilong Chen   +9 more
wiley   +1 more source

Intratumoral Hypoxia and Mechanisms of Immune Evasion Mediated by Hypoxia-Inducible Factors.

Physiology, 2021
Activation of the innate and adaptive immune systems represents a promising strategy for defeating cancer. However, during tumor progression, cancer cells battle to shift the balance from immune activation to immunosuppression.
G. Semenza
semanticscholar   +1 more source

Hypoxia-inducible factors and cancer

Clinical and Translational Oncology, 2007
Decreased oxygen availability is a common feature during embryonic development as well of malignant tumours. Hypoxia regulates many transcription factors, and one of the most studied is the hypoxia-inducible factor (HIF). As a consequence of HIF stabilisation, the cell constitutively upregulates the hypoxic programme resulting in the expression of ...
L. del Peso, Maria J. Calzada
openaire   +3 more sources

Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology.

Annual Review of Pathology, 2014
Hypoxia-inducible factors (HIFs) are transcriptional activators that function as master regulators of oxygen homeostasis, which is disrupted in disorders affecting the circulatory system and in cancer.
G. Semenza
semanticscholar   +1 more source

Hypoxia-inducible factor in brain

2001
HIF-1 is composed of HIF-1alpha and HIF-1beta protein subunits. HIF-1 is induced by hypoxia and binds to promoter/enhancer elements and stimulates the transcription of hypoxia-inducible target genes. Because HIF-1 activation might promote cell survival in hypoxic tissues, we studied the effect of stroke on the expression of HIF-1alpha, HIF-1beta and ...
Frank R. Sharp   +2 more
openaire   +3 more sources

Redox regulation of the hypoxia-inducible factor

Biological Chemistry, 2006
Reactive oxygen species (ROS) have long been considered only as cyto- and genotoxic. However, there is now compelling evidence that ROS also act as second messengers in response to various stimuli, such as growth factors, hormones and cytokines. The hypoxia-inducible transcription factor (HIF) is a master regulator of oxygen-sensitive gene expression ...
Fatima Mechta-Grigoriou   +1 more
openaire   +3 more sources

Structural integration in hypoxia-inducible factors

Nature, 2015
The hypoxia-inducible factors (HIFs) coordinate cellular adaptations to low oxygen stress by regulating transcriptional programs in erythropoiesis, angiogenesis and metabolism. These programs promote the growth and progression of many tumours, making HIFs attractive anticancer targets.
Dalei Wu   +4 more
semanticscholar   +4 more sources

Mitochondria and Hypoxia‐induced Gene Expression Mediated by Hypoxia‐inducible Factors

Annals of the New York Academy of Sciences, 2008
The influence of mitochondrial activity on gene expression programs, particularly those involved in neuroprotection and repair, is likely to play an important role in the pathophysiology of neurodegenerative diseases. One such gene expression program is activated by the cellular pathway that senses a decrease in optimal oxygen levels and leads to ...
Juan C. Chavez   +3 more
openaire   +3 more sources

Hypoxia-induced radioresistance is independent of hypoxia-inducible factor-1A in vitro

International Journal of Radiation Oncology*Biology*Physics, 2005
We sought to determine whether hypoxia-induced radioresistance is mediated by the transcription factor hypoxia-inducible factor-1alpha (HIF-1alpha).We used 2 mouse embryonic fibroblast cell lines transformed with H-ras and TAg, 1 HIF-1alpha+/+ and the other HIF-1alpha-/-.
Dennis F. Deen   +6 more
openaire   +3 more sources

The role of hypoxia-inducible factors in cancer

Cellular and Molecular Life Sciences, 2007
Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor that mediates the adaptive responses to hypoxia by effecting the transcription of numerous hypoxia-inducible genes. HIF is frequently overexpressed in solid tumors, and the transactivation of HIF targets in transformed cells provides a distinct survival advantage.
M. A. Maynard, M. Ohh
openaire   +3 more sources

Home - About - Disclaimer - Privacy