Results 351 to 360 of about 1,301,346 (361)

Hypoxia-inducible factor and cancer

Revista de Oncología, 2004
Oxygen is an essential requirement for mammalian cell metabolism. Cells respond to decreased oxygen tension by inducing adaptive responses aimed at restoring oxygen availability and maintaining energy balance. Most responses to hypoxia are mediated by the activation of a family of transcription factors termed hypoxia-inducible factors (HIF).
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Targeting hypoxia-inducible factors: therapeutic opportunities and challenges.

Nature reviews. Drug discovery, 2023
Xiaoyi Yuan, Wei Ruan, Bentley Bobrow, P. Carmeliet, Holger K Eltzschig   +4 more
semanticscholar   +1 more source

The Role of Hypoxia-Induced Factors

2010
The definition of “physiologically” normoxic conditions for either embryonic or adult cells varies significantly. The vast majority of adult normal tissues function at oxygen (O2) levels between 2 and 9%, with ambient air at 21% O2 [135]. Bone marrow, cartilage, kidney medulla, and thymus, on the other hand, can exist at 1% O2 or lower [135].
Richa Khatri, Ernestina Schipani
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Hypoxia Induces Transcription Factor ETS-1 via the Activity of Hypoxia-Inducible Factor-1

Biochemical and Biophysical Research Communications, 2001
ETS-1 plays an important role in angiogenesis and cancer invasion, and hypoxia is a common feature in these phenomena. We examined whether hypoxia influenced ETS-1 expression. Hypoxia induced ETS-1 in a human bladder cancer cell line, T24, and promoter analysis revealed that the deletion of -424 to -279 bp from the human ETS-1 promoter decreased the ...
Yasufumi Sato, Mayumi Abe, Hajime Kurosawa, Kunio Shirato, Manami Oikawa, Wataru Hida   +5 more
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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Nature, 1999
P. Maxwell, M. Wiesener, G. Chang, S. Clifford, E. C. Vaux, M. Cockman, C. Wykoff, C. Pugh, E. Maher, P. Ratcliffe   +9 more
semanticscholar   +1 more source

Hypoxia‐Inducible Factor 1 Inhibitors

2007
The tremendous progress in our understanding of the molecular mechanisms underlying the presence and consequences of hypoxia in human cancers has been accompanied by renewed enthusiasm for the development of therapeutic strategies targeting hypoxic cells signaling pathways.
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Hypoxia-Inducible Factor-1 [PDF]

, 2008
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Hypoxia-inducible Factor Crosses the Checkpoint

European Urology, 2016
Johannes Schödel, Victoria Lauer
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Hypoxia-Inducible Factor-1

2016
Tong Zhang, Zhaoji Liu, Zhaoyong Li, Huafeng Zhang   +3 more
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Expression of hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha with progression of keratinocytic neoplasms

Journal of Dermatological Science, 2009
Xie Lining, Satoshi Takeuchi, Takeshi Nakahara, Yoichi Moroi, Masakazu Takahara, Makiko Kido, Gaku Tsuji, Masutaka Furue, Sayaka Hayashida, Hiroshi Uchi   +9 more
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