Results 261 to 270 of about 522,720 (315)

Role of Tunneling Nanotubes in Arachidonic Acid Transfer and Macrophage Function Reprogramming in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
Tunneling nanotubes facilitate the transfer of long‐chain fatty acids, primarily arachidonic acid, from tumor cells to macrophages, leading to lipid accumulation and activation of the PI3K‐Akt pathway. This drives a shift from the anti‐tumor CD5L⁺ phenotype to a pro‐tumor TREM2⁺ phenotype.
Meiru Chen, Shangyumeng Zhao, Xiaoli Xie, Jiaqi Wang, Miao Su, Lixian Zhang, Ruolin Cui, Dongqiang Zhao   +7 more
wiley   +1 more source

Glycogen supports glycolytic plasticity in neurons. [PDF]

Proc Natl Acad Sci U S A
Singh M, Wolfe AD, Vishwanath AA, Tsives A, Gonzalez IJ, Emerson SE, Goodman R, Colón-Ramos D.   +7 more
europepmc   +1 more source

Nrf2 Drives Epigenetic Reprogramming and Acts as the Master Regulator of KLF4 Expression and Activity in Arsenic‐Induced Transformation

Advanced Science, EarlyView.
Nrf2 isn't just a protector—it's a driver of cancer stemness. The study uncovers how arsenic‐activated Nrf2 directly upregulates KLF4, a key pluripotency factor, fueling oncogenic reprogramming. Through enhancer activation and self‐reinforcing loop, Nrf2 and KLF4 co‐opt gene networks linked to epithelial‐to‐mesenchymal transition and tumor growth ...
Ziwei Wang, Zhuoyue Bi, Jessica Bamrah, Yiran Qiu, Wenxuan Zhang, Bandar Saeed Almutairy, Haoyan Ji, John D. Haley, Chitra Thakur, Fei Chen   +9 more
wiley   +1 more source

The translational inhibitor 4EBP/Thor is required for Drosophila adaptation to hypoxia. [PDF]

Sci Rep
Sorianello E, Katz MJ, Acevedo JM, Melani M, Perez-Perri JI, Wappner P.   +5 more
europepmc   +1 more source

Pseudohypoxic stabilization of HIF1α via cyclophilin D suppression promotes melanoma metastasis. [PDF]

Signal Transduct Target Ther
Park HK, Hu S, Kim SY, Yoon S, Yoon NG, Lee JH, Choi W, Kong SY, Kim JH, Nam D, Kang BH.   +10 more
europepmc   +1 more source

Effects of "Living High-Training Low and High" on Sleep, Heart Rate Variability, and Psychological Responses in Elite Female Cyclists. [PDF]

Eur J Sport Sci
Pirlot T, Mihailovic T, Gimenez P, Millet GP, Brocherie F, Fruchart E, Ravier G, Baron B, Bouzigon R, Guirronnet S, Brunet E, Groslambert A.   +11 more
europepmc   +1 more source

Hypoxia disrupts metabolism in coral and sea anemone larvae. [PDF]

J Exp Biol
Glass BH, Barott KL.
europepmc   +1 more source

Hypoxic Status in COPD and ARDS Patients: Impact on Lipid Signature. [PDF]

Int J Mol Sci
Morano C, Sadikovic A, Dei Cas M, Rinaldo RF, Duca L, Rubino FM, Mondoni M, Chiumello D, Ottolenghi S, Samaja M, Paroni R.   +10 more
europepmc   +1 more source

p75NTR modulation prevents cellular, cortical activity and cognitive dysfunctions caused by perinatal hypoxia. [PDF]

Brain
Chattopadhyaya B, Lee KKY, Carreño-Muñoz MI, Paris-Rubianes A, Lavertu-Jolin M, Berryer MH, Longo FM, Di Cristo G.   +7 more
europepmc   +1 more source