Results 261 to 270 of about 939,686 (311)

Hypoxia-Induced Histone Lactylation Drives Cisplatin Resistance in Bladder Cancer by Promoting RBM15-Dependent m⁶A Methylation of IGFBP3. [PDF]

Research (Wash D C)
Sun J, Shi Y, Yu K, Huang S, Lu D, Niu X, Li Y, Wang F, Ma X, Li J, Liu X, Xie L, Huang H, Liu B.   +13 more
europepmc   +1 more source

NIR‐II Responsive Multifunctional Scaffold Enabling “Kill‐Modulation‐Build” Synergistic Therapy for Infectious Bone Defects

Advanced Science, EarlyView.
A novel multifunctional scaffold with photothermal effects is developed for infected bone defect repair. It facilitates angiogenesis and osteogenesis while eliminating bacteria through hyperthermia. Additionally, the scaffold promotes macrophage polarization from M1 to M2 via ROS scavenging, enhancing anti‐inflammatory activity. This study demonstrates
Qifei Yang, Shu Lou, Yuan Zhang, Zhurun Fang, Changyue Xing, Wentao Wang, Minxuan Han, Zhendong Wang, Ben Zhong Tang, Ming Zhang   +9 more
wiley   +1 more source

CACNB4 attenuates cardiac dysfunction by regulating calcium and ATP levels via interaction with RyR2. [PDF]

Eur J Med Res
Jiang S, Hong M, Zhang J, Xu F, Zhang X, Zhang G.   +5 more
europepmc   +1 more source

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source

Hypoxia-mediated regulation of mRNA metabolism: from transcription to stability. [PDF]

Cell Commun Signal
Zhang X, Zhang P, Zhang C, Yuan Z, Li S.
europepmc   +1 more source

Inactivation of AXL in Cardiac Fibroblasts Alleviates Right Ventricular Remodeling in Pulmonary Hypertension

Advanced Science, EarlyView.
Pulmonary hypertension (PH) is a progressive condition with high morbidity and mortality, largely owing to right ventricular (RV) failure resulting from maladaptive remodeling. Our study provides strong evidence in support of a critical, detrimental role for AXL as a previously unrecognized determinant driving RV fibrotic pathology in PH.
Li‐Wei Wu, Min Chen, Chen‐Yu Jiang, Dai‐Ji Jiang, Xu Zhang, Xiao‐He Xu, Yi‐Wei Liu, Bei Feng, Lin‐Cai Ye, Yang‐Yang He, Xu Huang, Yi‐Chi Zhang, Xing‐Liang Zhou, Yi Shen, Tian‐Yu Liu, Li‐Jun Fu, Yi Yan, Hao Zhang   +17 more
wiley   +1 more source

Exenatide Is Neuroprotective in a New Rabbit Model of Hypoxia-Ischemia. [PDF]

Cells
Rocha-Ferreira E, Carlsson M, Svedin P, Ebefors K, Herrock O, Leverin AL, Hagberg H.   +6 more
europepmc   +1 more source

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

Advanced Science, EarlyView.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon, May Thazin Phoo, Yubin Kim, Jinsung Ahn, April Kim, Jutaek Nam, Soo‐Hong Lee, James J. Moon, Sejin Son   +8 more
wiley   +1 more source

Evaluating anti-sickling therapies for sickle cell disease: a microfluidic assay for red blood cell-mediated microvascular occlusion under hypoxia.

Lab Chip
Sekyonda Z, Du Y, Oshabaheebwa S, Fadaei P, Ley YB, Abonga C, Suster MA, Mohseni P, Gurkan UA.   +8 more
europepmc   +1 more source

PIM1 induces hypoxia-related fibroblast senescence in a mouse model of stress urinary incontinence. [PDF]

PLoS One
Xiao Y, Chen M, Li L, Chen L, Tian X, Huang X, Zhu F, Li B, Hong L.   +8 more
europepmc   +1 more source